Is heptelidic (koningic) acid a microbial hormone that regulates secondary metabolism in the biocontrol fungus ?

Abdel-Wahab AF, Mahmoud W, Al-Harizy RM (2019) Targeting glucose metabolism to suppress cancer progression: prospective of anti-glycolytic cancer therapy. Pharmacol Res 150:104511. https://doi.org/10.1016/j.phrs.2019.104511

Article  PubMed  CAS  Google Scholar 

Amaike S, Keller NP (2009) Distinct roles for VelA and LaeA in development and pathogenesis of Aspergillus flavus. Eukaryot Cell 8:1051–1060. https://doi.org/10.1128/EC.00088-09

Article  PubMed  PubMed Central  CAS  Google Scholar 

Bansal R, Sherkhane PD, Oulkar D et al (2018) The viridinbiosynthesisgene cluster of Trichoderma virens and its conservancy in the bat white-nose fungus Pseudogymnoascus destructans. ChemSelect 3:1289–1293. https://doi.org/10.1002/slct.201703035

Article  CAS  Google Scholar 

Bansal R, Pachauri S, Gururajaiah D et al (2021) Dual role of a dedicated GAPDH in the biosynthesis of volatile and non-volatile metabolites- novel insights into the regulation of secondary metabolism in Trichoderma virens. Microbiol Res 253:126862. https://doi.org/10.1016/j.micres.2021.126862

Article  PubMed  CAS  Google Scholar 

Bok JW, Keller NP (2004) LaeA, a regulator of secondary metabolism in Aspergillus spp. Eukaryot Cell 3:527–535. https://doi.org/10.1128/EC.3.2.527-535.2004

Article  PubMed  PubMed Central  CAS  Google Scholar 

Crutcher FK, Parich A, Schuhmacher R et al (2013) A putative terpene cyclase, vir4, is responsible for the biosynthesis of volatile terpene compounds in the biocontrol fungus Trichoderma virens. Fungal Genet Biol 56:67–77. https://doi.org/10.1016/j.fgb.2013.05.003

Article  PubMed  CAS  Google Scholar 

Endo A, Hasum K, Hasumi K et al (1985) Specific inhibition of glyceraldehyde-3-phosphate dehydrogenase by koningic acid (Heptelidic acid). J Antibiot 38:920–925. https://doi.org/10.7164/antibiotics.38.920

Article  CAS  Google Scholar 

Ganapathy-Kanniappan S (2018) Evolution of GAPDH as a druggable target of tumor glycolysis? Expert Opin Ther Targets 22:295–298. https://doi.org/10.1080/14728222.2018.1449834

Article  PubMed  CAS  Google Scholar 

Ghate T, Soneji K, Barvkar V et al (2022) Thiourea mediated ROS-metabolites reprogramming restores root system architecture under arsenic stress in rice. J Hazard Mater 435:129020. https://doi.org/10.1016/j.jhazmat.2022.129020

Article  PubMed  CAS  Google Scholar 

Horinouchi S (2002) A microbial hormone A-factor as a master switch for morphological differentiation and secondary metabolism in Streptomyces griseus. Front Biosci 7:A897. https://doi.org/10.2741/A897

Article  Google Scholar 

Horinouchi S, Beppu T (1993) A-factor and streptomycin biosynthesis in Streptomyces griseus. Antonie Van Leeuwenhoek 64:177–186. https://doi.org/10.1007/BF00873026

Article  PubMed  Google Scholar 

Horinouchi S, Beppu T (1994) A-factor as a microbial hormone that controls cellular differentiation and secondary metabolism in Streptomyces griseus. Mol Microbiol 12:859–864. https://doi.org/10.1111/j.1365-2958.1994.tb01073.x

Article  PubMed  CAS  Google Scholar 

Horinouchi S, Beppu T (2007) Hormonal control by A-factor of morphological development and secondary metabolism in Streptomyces. Proc Jpn Acad Ser B Phys Biol Sci 83:277–295. https://doi.org/10.2183/pjab.83.277

Article  PubMed  PubMed Central  CAS  Google Scholar 

Horinouchi S, Onaka H, Yamazaki H et al (2000) Isolation of DNA fragments bound by transcriptional factors, AdpA and ArpA, in the A-factor regulatory cascade. Actinomycetologica 14:37–42. https://doi.org/10.3209/saj.14_37

Article  Google Scholar 

Howell CR, Stipanovic RD, Lumsden RD (1993) Antibiotic production by strains of Gliocladium virens and its relation to the biocontrol of cotton seedling diseases. Biocontrol Sci Technol 3:435–441. https://doi.org/10.1080/09583159309355298

Article  Google Scholar 

Isozaki S, Konishi H, Tanaka H et al (2022) Probiotic-derived heptelidic acid exerts antitumor effects on extraintestinal melanoma through glyceraldehyde-3-phosphate dehydrogenase activity control. BMC Microbiol 22:110. https://doi.org/10.1186/s12866-022-02530-0

Article  PubMed  PubMed Central  CAS  Google Scholar 

Itoh Y, Kodama K, Furuya K et al (1980) A new sesquiterpene antibiotic, heptelidic acid producing organisms, fermentation, isolation and characterization. J Antibiot 33:468–473. https://doi.org/10.7164/antibiotics.33.468

Article  CAS  Google Scholar 

Jing C, Li Y, Gao Z, Wang R (2022) Antitumor activity of koningicacid in thyroid cancer by inhibiting cellular glycolysis. Endocrine 75:169–177. https://doi.org/10.1007/s12020-021-02822-x

Article  PubMed  CAS  Google Scholar 

Keller NP (2019) Fungal secondary metabolism: regulation, function and drug discovery. Nat Rev Microbiol 17:167–180. https://doi.org/10.1038/s41579-018-0121-1

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kong D, Wang X, Nie J, Niu G (2019) Regulation of antibiotic production by signalingmolecules in Streptomyces. Front Microbiol 10:2927. https://doi.org/10.3389/fmicb.2019.02927

Article  PubMed  PubMed Central  Google Scholar 

Kumagai S, Narasaki R, Hasumi K (2008) Glucose-dependent active ATP depletion by koningic acid kills high-glycolytic cells. Biochem Biophys Res Commun 365:362–368. https://doi.org/10.1016/j.bbrc.2007.10.199

Article  PubMed  CAS  Google Scholar 

Liberti MV, Dai Z, Wardell SE et al (2017) A predictive model for selective targeting of the Warburg effect through GAPDH inhibition with a natural product. Cell Metab 26:648-659.e8. https://doi.org/10.1016/j.cmet.2017.08.017

Article  PubMed  PubMed Central  CAS  Google Scholar 

Liberti MV, Allen AE, Ramesh V et al (2020) Evolved resistance to partial GAPDH inhibition results in loss of the Warburg effect and in a different state of glycolysis. J Biol Chem 295:111–124. https://doi.org/10.1074/jbc.RA119.010903

Article  PubMed  CAS  Google Scholar 

Lin X-T, Zhang J, Liu Z-Y et al (2023) Elevated FBXW10 drives hepatocellular carcinoma tumorigenesis via AR-VRK2 phosphorylation-dependent GAPDH ubiquitination in male transgenic mice. Cell Rep 42:112812. https://doi.org/10.1016/j.celrep.2023.112812

Article  PubMed  CAS  Google Scholar 

Malinich EA, Wang K, Mukherjee PK et al (2019) Differential expression analysis of Trichoderma virens RNA reveals a dynamic transcriptome during colonization of Zea mays roots. BMC Genomics 20:280. https://doi.org/10.1186/s12864-019-5651-z

Article  PubMed  PubMed Central  Google Scholar 

Mukherjee PK, Shrestha SM, Mukhopadhyay AN (1993) Baiting with Sclerotium rolfsii for selective isolation of Gliocladium virens from natural soil. Biocontrol Sci Technol 3:101–104. https://doi.org/10.1080/09583159309355265

Article  Google Scholar 

Mukherjee M, Horwitz BA, Sherkhane PD et al (2006) A secondary metabolite biosynthesis cluster in Trichoderma virens: evidence from analysis of genes underexpressed in a mutant defective in morphogenesis and antibiotic production. Curr Genet 50:193–202. https://doi.org/10.1007/s00294-006-0075-0

Article  PubMed  CAS  Google Scholar 

Mukherjee PK, Kenerley CM (2010) Regulation of morphogenesis and biocontrol properties in Trichoderma virens by a VELVET protein, Vel1. Appl Environ Microbiol 76(7):2345–2352. https://doi.org/10.1128/AEM.02391-09

Mukherjee PK, Horwitz BA, Kenerley CM (2012) Secondary metabolism in Trichoderma–a genomic perspective. Microbiology 158:35–45. https://doi.org/10.1099/mic.0.053629-0

Article  PubMed  CAS  Google Scholar 

Mukherjee PK, Hurley JF, Taylor JT, Puckhaber L, Lehner S, Druzhinina I, Schumacher R, Kenerley CM (2018) Ferricrocin, the intracellular siderophore of Trichoderma virens, is involved in growth, conidiation, gliotoxin biosynthesis and induction of systemic resistance in maize. Biochem Biophys Res Commun 505(2):606–611. https://doi.org/10.1016/j.bbrc.2018.09.170

Nakazawa M, Uehara T, Nomura Y (1997) Koningicacid (a potent glyceraldehyde-3-phosphate dehydrogenase inhibitor) -induced fragmentation and condensation of DNA in NG108-15 cells. J Neurochem 68:2493–2499. https://doi.org/10.1046/j.1471-4159.1997.68062493.x

Comments (0)

No login
gif