Pacesa M, Pelea O, Jinek M. Past, present, and future of CRISPR genome editing technologies. Cell. 2024;187:1076–100.

Article  CAS  PubMed  Google Scholar 

Poirot L, Philip B, Schiffer-Mannioui C, Le Clerre D, Chion-Sotinel I, Derniame S, et al. Multiplex genome-edited T-cell manufacturing platform for “off-the-shelf” adoptive T-cell immunotherapies. Cancer Res. 2015;75:3853–64.

Article  CAS  PubMed  Google Scholar 

Bolideei M, Barzigar R, Gahrouei RB, Mohebbi E, Haider KH, Paul S, et al. Applications of gene editing and nanotechnology in stem cell-based therapies for human diseases. Stem Cell Rev Rep. 2025;21:1–30.

Article  Google Scholar 

Garneau JE, Dupuis MÈ, Villion M, Romero DA, Barrangou R, Boyaval P, et al. The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA. Nature. 2010;468:67–71.

Article  CAS  PubMed  Google Scholar 

Cong L, Ran FA, Cox D, Lin S, Barretto R, Habib N, et al. Multiplex genome engineering using CRISPR/Cas systems. Science. 2013;339:819–23.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ran FA, Hsu PD, Wright J, Agarwala V, Scott DA, Zhang F. Genome engineering using the CRISPR-Cas9 system. Nat Protoc. 2013;8:2281–308.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu D, Cao D, Han R. Recent advances in therapeutic gene-editing technologies. Mol Ther. 2025;33:2619–44.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li G, Li X, Zhuang S, Wang L, Zhu Y, Chen Y, et al. Gene editing and its applications in biomedicine. Sci China Life Sci. 2022;65:660–700.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mali P, Yang L, Esvelt KM, Aach J, Guell M, DiCarlo JE, et al. RNA-guided human genome engineering via Cas9. Science. 2013;339:823–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou W, Yang J, Zhang Y, Hu X, Wang W. Current landscape of gene-editing technology in biomedicine: Applications, advantages, challenges, and perspectives. MedComm. 2022;3:155.

Article  Google Scholar 

Hinnen A, Hicks JB, Fink GR. Transformation of yeast. Proc Natl Acad Sci. 1978;75:1929–33.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee J, Bayarsaikhan D, Bayarsaikhan G, Kim JS, Schwarzbach E, Lee B. Recent advances in genome editing of stem cells for drug discovery and therapeutic application. Pharmacol Therapeutics. 2020;209:107501.

Article  CAS  Google Scholar 

Jeffries MA. Epigenetic editing: How cutting-edge targeted epigenetic modification might provide novel avenues for autoimmune disease therapy. Clin Immunol. 2018;196:49–58.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tao J, Bauer DE, Chiarle R. Assessing and advancing the safety of CRISPR-Cas tools: from DNA to RNA editing. Nat Commun. 2023;14:212.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang MGZXQ, Glass ZA, Xu Q. Non-viral delivery of genome-editing nucleases for gene therapy. Gene Ther. 2017;24:144–50.

Article  CAS  PubMed  Google Scholar 

Chen F, Pruett-Miller SM, Huang Y, Gjoka M, Duda K, Taunton J, et al. High-frequency genome editing using ssDNA oligonucleotides with zinc-finger nucleases. Nat methods. 2011;8:753–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sfeir A, Symington LS. Microhomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway? Trends Biochem Sci. 2015;40:701–14.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim YG, Cha J, Chandrasegaran S. Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain. Proc Natl Acad Sci. 1996;93:1156–60.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Diakun GP, Fairall L, Klug A. EXAFS study of the zinc-binding sites in the protein transcription factor IIIA. Nature. 1986;324:698–9.

Article  CAS  PubMed  Google Scholar 

Engineering polydactyl zinc-finger transcription factors. Nat Biotechnol. 2002;20:135–41.

Beerli RR, Schopfer U, Dreier B, Barbas CF. Chemically regulated zinc finger transcription factors. J Biol Chem. 2000;275:32617–27.

Article  CAS  PubMed  Google Scholar 

Nikolova EN, Stanfield RL, Dyson HJ, Wright PE. CH··· O hydrogen bonds mediate highly specific recognition of methylated CpG sites by the zinc finger protein Kaiso. Biochemistry. 2018;57:2109–20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fairall L, Schwabe JW, Chapman L, Finch JT, Rhodes D. The crystal structure of a two zinc-finger peptide reveals an extension to the rules for zinc-finger/DNA recognition. Nature. 1993;366:483–7.

Article  CAS  PubMed  Google Scholar 

Directed evolution of an enhanced and highly efficient FokI cleavage domain for zinc finger nucleases. J Mol Biol. 2010;400:96–107.

Smith J, Bibikova M, Whitby FG, Reddy AR, Chandrasegaran S, Carroll D. Requirements for double-strand cleavage by chimeric restriction enzymes with zinc finger DNA-recognition domains. Nucleic Acids Res. 2000;28:3361–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li H, Yang Y, Hong W, Huang M, Wu M, Zhao X. Applications of genome editing technology in the targeted therapy of human diseases: mechanisms, advances and prospects. Signal Transduction Targeted Ther. 2020;5:1.

Paschon DE, Lussier S, Wangzor T, Xia DF, Li PW, Hinkley SJ, et al. Diversifying the structure of zinc finger nucleases for high-precision genome editing. Nat Commun. 2019;10:1133.

Article  PubMed  PubMed Central  Google Scholar 

Beumer KJ, Trautman JK, Bozas A, Liu JL, Rutter J, Gall JG, et al. Efficient gene targeting in Drosophila by direct embryo injection with zinc-finger nucleases. Proc Natl Acad Sci USA. 2008;105:19821–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Boch J, Scholze H, Schornack S, Landgraf A, Hahn S, Kay S, et al. Breaking the code of DNA binding specificity of TAL-type III effectors. Science. 2009;326:1509–12.

Article  CAS  PubMed  Google Scholar 

Moscou MJ, Bogdanove AJ. A simple cipher governs DNA recognition by TAL effectors. Science. 2009;326:1501.

Article  CAS  PubMed  Google Scholar 

Doyle EL, Stoddard BL, Voytas DF, Bogdanove AJ. TAL effectors: highly adaptable phytobacterial virulence factors and readily engineered DNA-targeting proteins. Trends Cell Biol. 2013;23:390–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen K, Gao C. TALENs: customizable molecular DNA scissors for genome engineering of plants. J Genet Genomics. 2013;40:271–9.

Article  PubMed  Google Scholar 

Holkers M, Maggio I, Liu J, Janssen JM, Miselli F, Mussolino C, et al. Differential integrity of TALE nuclease genes following adenoviral and lentiviral vector gene transfer into human cells. Nucleic acids Res. 2013;41:63.

Article