Hall JM, Couse JF, Korach KS. The multifaceted mechanisms of estradiol and estrogen receptor signaling. J Biol Chem. 2001;276:36869–72.
Article CAS PubMed Google Scholar
Arnal JF, Lenfant F, Metivier R, Flouriot G, Henrion D, Adlanmerini M, et al. Membrane and nuclear estrogen receptor alpha actions: from tissue specificity to medical implications. Physiol Rev. 2017;97:1045–87.
Couse JF, Korach KS. Estrogen receptor null mice: what have we learned and where will they lead us? Endocr Rev. 1999;20:358–417.
Article CAS PubMed Google Scholar
Sanderson PA, Critchley HOD, Williams ARW, Arends MJ, Saunders PTK. New concepts for an old problem: the diagnosis of endometrial hyperplasia. Hum Reprod Update. 2017;23:232–54.
PubMed PubMed Central Google Scholar
Jia M, Dahlman-Wright K, Gustafsson JÅ. Estrogen receptor alpha and beta in health and disease. Best Pr Res Clin Endocrinol Metab. 2015;29:557–68.
McDonnell DP. The molecular pharmacology of SERMs. Trends Endocrinol Metab. 1999;10:301–11.
Article CAS PubMed Google Scholar
Rugo HS, Rumble RB, Macrae E, Barton DL, Connolly HK, Dickler MN, et al. Endocrine therapy for hormone receptor–positive metastatic breast cancer: American Society of Clinical Oncology guideline. JCO. 2016;34:3069–103.
Toy W, Shen Y, Won H, Green B, Sakr RA, Will M, et al. ESR1 ligand-binding domain mutations in hormone-resistant breast cancer. Nat Genet. 2013;45:1439–45.
Article CAS PubMed PubMed Central Google Scholar
Brett JO, Spring LM, Bardia A, Wander SA. ESR1 mutation as an emerging clinical biomarker in metastatic hormone receptor-positive breast cancer. Breast Cancer Res. 2021;23:85.
Article CAS PubMed PubMed Central Google Scholar
Jeselsohn R, Buchwalter G, De Angelis C, Brown M, Schiff R. ESR1 mutations—a mechanism for acquired endocrine resistance in breast cancer. Nat Rev Clin Oncol. 2015;12:573–83.
Article CAS PubMed PubMed Central Google Scholar
Toy W, Weir H, Razavi P, Lawson M, Goeppert AU, Mazzola AM, et al. Activating ESR1 mutations differentially affect the efficacy of ER antagonists. Cancer Discov. 2017;7:277–87.
Article CAS PubMed Google Scholar
Robinson DR, Wu YM, Vats P, Su F, Lonigro RJ, Cao X, et al. Activating ESR1 mutations in hormone-resistant metastatic breast cancer. Nat Genet. 2013;45:1446–51.
Article CAS PubMed PubMed Central Google Scholar
Vrtačnik P, Ostanek B, Mencej-Bedrač S, Marc J. The many faces of estrogen signaling. Biochem Med. 2014;24:329–42.
Klinge CM. Estrogen receptor interaction with estrogen response elements. Nucleic Acids Res. 2001;29:2905–19.
Article CAS PubMed PubMed Central Google Scholar
O’Lone R, Frith MC, Karlsson EK, Hansen U. Genomic targets of nuclear estrogen receptors. Mol Endocrinol. 2004;18:1859–75.
Mao C, Patterson NM, Cherian MT, Aninye IO, Zhang C, Montoya JB, et al. A new small molecule inhibitor of estrogen receptor alpha binding to estrogen response elements blocks estrogen-dependent growth of cancer cells. J Biol Chem. 2008;283:12819–30.
Article CAS PubMed PubMed Central Google Scholar
Chen H, Stuart W, Hu B, Nguyen L, Huang G, Clemens TL, et al. Creation of estrogen resistance in vivo by transgenic overexpression of the heterogeneous nuclear ribonucleoprotein-related estrogen response element binding protein. Endocrinology. 2005;146:4266–73.
Article CAS PubMed Google Scholar
Chen H, Hewison M, Adams JS. Control of estradiol-directed gene transactivation by an intracellular estrogen-binding protein and an estrogen response element-binding protein. Mol Endocrinol. 2008;22:559–69.
Article CAS PubMed Google Scholar
Chen H, Clemens TL, Hewison M, Adams JS. Estradiol and tamoxifen mediate rescue of the dominant-negative effects of estrogen response element-binding protein in vivo and in vitro. Endocrinology. 2009;150:2429–35.
Article CAS PubMed Google Scholar
Dixon JM. Exemestane: a potent irreversible aromatase inactivator and a promising advance in breast cancer treatment. Expert Rev Anticancer Ther. 2002;2:267–75.
Article CAS PubMed Google Scholar
Early Breast Cancer Trialists’ Collaborative Group (EBCTCG). Aromatase inhibitors versus tamoxifen in premenopausal women with oestrogen receptor-positive early-stage breast cancer treated with ovarian suppression: a patient-level meta-analysis of 7030 women from four randomised trials. Lancet Oncol. 2022;23:382–92.
Gossen M, Freundlieb S, Bender G, Müller G, Hillen W, Bujard H. Transcriptional activation by tetracyclines in mammalian cells. Science. 1995;268:1766–9.
Article CAS PubMed Google Scholar
Austin S, Ziese M, Sternberg N. A novel role for site-specific recombination in maintenance of bacterial replicons. Cell. 1981;25:729–36.
Article CAS PubMed Google Scholar
Huang J, Li X, Yi P, Hilf R, Bambara RA, Muyan M. Targeting estrogen-responsive elements (EREs): design of potent transactivators for ERE-containing genes. Mol Cell Endocrinol. 2004;218:65–78.
Article CAS PubMed Google Scholar
Kuntz MA, Shapiro DJ. Dimerizing the estrogen receptor DNA binding domain enhances binding to estrogen response elements. J Biol Chem. 1997;272:27949–56.
Article CAS PubMed Google Scholar
Shui S, Wang S, Liu J. Systematic investigation of the effects of multiple SV40 nuclear localization signal fusion on the genome editing activity of purified SpCas9. Bioengineering. 2022;9:83.
Article CAS PubMed PubMed Central Google Scholar
Abramson J, Adler J, Dunger J, Evans R, Green T, Pritzel A, et al. Accurate structure prediction of biomolecular interactions with AlphaFold 3. Nature. 2024;630:493–500.
Article CAS PubMed PubMed Central Google Scholar
McDonnell DP, Norris JD. Connections and regulation of the human estrogen receptor. Science. 2002;296:1642–4.
Article CAS PubMed Google Scholar
Welboren WJ, Sweep FCGJ, Span PN, Stunnenberg HG. Genomic actions of estrogen receptor alpha: what are the targets and how are they regulated? Endocr Relat Cancer. 2009;16:1073–89.
Article CAS PubMed Google Scholar
Wakeling AE, Dukes M, Bowler J. A potent specific pure antiestrogen with clinical potential. Cancer Res. 1991;51:3867–73.
Berthois Y, Katzenellenbogen JA, Katzenellenbogen BS. Phenol red in tissue culture media is a weak estrogen: implications concerning the study of estrogen-responsive cells in culture. Proc Natl Acad Sci USA. 1986;83:2496–2500.
Article CAS PubMed PubMed Central Google Scholar
Utomo AR, Nikitin AY, Lee WH. Temporal, spatial, and cell type-specific control of Cre-mediated DNA recombination in transgenic mice. Nat Biotechnol. 1999;17:1091–6.
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