Bordoni M, Scarian E, Rey F, Gagliardi S, Carelli S, Pansarasa O, et al. Biomaterials in neurodegenerative disorders: a promising therapeutic approach. Int J Mol Sci. 2020. https://doi.org/10.3390/ijms21093243.

Article  PubMed  PubMed Central  Google Scholar 

Espinós C, Galindo MI, García-Gimeno MA, Ibáñez-Cabellos JS, Martínez-Rubio D, Millán JM, et al. Oxidative stress, a crossroad between rare diseases and neurodegeneration. Antioxidants. 2020. https://doi.org/10.3390/antiox9040313.

Article  PubMed  PubMed Central  Google Scholar 

Finkel T, Holbrook NJ. Oxidants, oxidative stress and the biology of ageing. Nature. 2000;408(6809):239–47. https://doi.org/10.1038/35041687.

Article  CAS  PubMed  Google Scholar 

Ewald CY, Hourihan JM, Bland MS, Obieglo C, Katic I, Moronetti Mazzeo LE, et al. NADPH oxidase-mediated redox signaling promotes oxidative stress resistance and longevity through memo-1 in C. elegans. Elife. 2017. https://doi.org/10.7554/eLife.19493.

Article  PubMed  PubMed Central  Google Scholar 

Mittal M, Siddiqui MR, Tran K, Reddy SP, Malik AB. Reactive oxygen species in inflammation and tissue injury. Antioxid Redox Signal. 2014;20(7):1126–67. https://doi.org/10.1089/ars.2012.5149.

Article  CAS  PubMed  Google Scholar 

Liguori I, Russo G, Curcio F, Bulli G, Aran L, Della-Morte D, et al. Oxidative stress, aging, and diseases. Clin Interv Aging. 2018;13:757–72. https://doi.org/10.2147/CIA.S158513.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Baptista-Silva S, Borges S, Ramos OL, Pintado M, Sarmento B. The progress of essential oils as potential therapeutic agents: a review. J Essent Oil Res. 2020;32(4):279–95. https://doi.org/10.1080/10412905.2020.1746698.

Article  CAS  Google Scholar 

Mancianti F, Ebani VV. Biological activity of essential oils. Molecules. 2020. https://doi.org/10.3390/molecules25030678.

Article  PubMed  PubMed Central  Google Scholar 

Banu F, Dawood N, Lakshmi YSL, Sivaraman G, Brinda V. Antioxidant activity of geraniol on N-nitrosodiethylamine-induced hepatocarcinogenesis in wistar albino rats. Ind J Oncol Radiat Biol. 2014;2:4–9.

Google Scholar 

Mączka W, Wińska K, Grabarczyk M. One hundred faces of geraniol. Molecules. 2020;25:3303. https://doi.org/10.3390/molecules25143303.

Article  CAS  PubMed  PubMed Central  Google Scholar 

De Fazio L, Spisni E, Cavazza E, Strillacci A, Candela M, Centanni M, et al. Dietary geraniol by oral or enema administration strongly reduces dysbiosis and systemic inflammation in dextran sulfate sodium-treated mice. Front Pharmacol. 2016;7:38. https://doi.org/10.3389/fphar.2016.00038.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R. A C. elegans mutant that lives twice as long as wild type. Nature. 1993;366(6454):461–4. https://doi.org/10.1038/366461a0.

Article  CAS  PubMed  Google Scholar 

Samuelson AV, Carr CE, Ruvkun G. Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants. Genes Dev. 2007;21(22):2976–94. https://doi.org/10.1101/gad.1588907.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chalfie M, Tu Y, Euskirchen G, Ward WW, Prasher DC. Green fluorescent protein as a marker for gene expression. Science. 1994;263(5148):802–5. https://doi.org/10.1126/science.263.5148.802.

Article  CAS  PubMed  Google Scholar 

Kerr RA, Schafer WR. Intracellular Ca2⁺ imaging in C. elegans. In: Strange K, editor. C. elegans. Methods in Molecular Biology. Totowa (NJ): Humana Press; 2006. pp. 253–264. https://doi.org/10.1385/1-59745-151-7:253.

Kenyon CJ. The genetics of ageing. Nature. 2010;464(7288):504–12. https://doi.org/10.1038/nature08980.

Article  CAS  PubMed  Google Scholar 

Fontana L, Partridge L, Longo VD. Extending healthy life span--from yeast to humans. Science. 2010;328(5976):321–6. https://doi.org/10.1126/science.1172539.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cohen E, Dillin A. The insulin paradox: aging, proteotoxicity and neurodegeneration. Nat Rev Neurosci. 2008;9(10):759–67. https://doi.org/10.1038/nrn2474.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hsu AL, KENYy CT, Kenyon C. Regulation of aging and age-related disease by DAF-16 and heat-shock factor. Science. 2003;300(5622):1142–5. https://doi.org/10.1126/science.1083701.

Article  CAS  PubMed  Google Scholar 

Cohen E, Bieschke J, Perciavalle RM, Kelly JW, Dillin A. Opposing activities protect against age-onset proteotoxicity. Science. 2006;313(5793):1604–10. https://doi.org/10.1126/science.1124646.

Article  CAS  PubMed  Google Scholar 

Anckar J, Sistonen L. Regulation of HSF1 function in the heat stress response: implications in aging and disease. Annu Rev Biochem. 2011;80:1089–115. https://doi.org/10.1146/annurev-biochem-060809-095203.

Article  CAS  PubMed  Google Scholar 

Steinbaugh MJ, Narasimhan SD, Robida-Stubbs S, Moronetti Mazzeo LE, Dreyfuss JM, Hourihan JM, et al. Lipid-mediated regulation of SKN-1/Nrf in response to germ cell absence. Elife. 2015;4:e07836. https://doi.org/10.7554/eLife.07836.

Article  PubMed  PubMed Central  Google Scholar 

Teixeira-Castro A, Ailion M, Jalles A, Brignull HR, Vilaca JL, Dias N, et al. Neuron-specific proteotoxicity of mutant ataxin-3 in C. elegans: rescue by the DAF-16 and HSF-1 pathways. Hum Mol Genet. 2011;20(15):2996–3009. https://doi.org/10.1093/hmg/ddr203.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Andersen N, Veuthey T, Blanco MG, Silbestri GF, Rayes D, De Rosa MJ. 1-mesityl-3-(3-sulfonatopropyl) imidazolium protects against oxidative stress and delays proteotoxicity in C. elegans. Front Pharmacol. 2022;13:908696. https://doi.org/10.3389/fphar.2022.908696.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Giunti S, Andersen N, Rayes D, De Rosa MJ. Drug discovery: insights from the invertebrate Caenorhabditis elegans. Pharmacol Res Perspect. 2021;9(2):e00721. https://doi.org/10.1002/prp2.721.

Article  PubMed  PubMed Central  Google Scholar 

Lakso M, Vartiainen S, Moilanen AM, Sirvio J, Thomas JH, Nass R, et al. Dopaminergic neuronal loss and motor deficits in Caenorhabditis elegans overexpressing human alpha-synuclein. J Neurochem. 2003;86(1):165–72. https://doi.org/10.1046/j.1471-4159.2003.01809.x.

Article  CAS  PubMed  Google Scholar 

Simonetta SH, Golombek DA. An automated tracking system for Caenorhabditis elegans locomotor behavior and circadian studies application. J Neurosci Methods. 2007;161(2):273–80. https://doi.org/10.1016/j.jneumeth.2006.11.015.

Article  PubMed  Google Scholar 

Knoefler D, Thamsen M, Koniczek M, Niemuth NJ, Diederich AK, Jakob U. Quantitative in vivo redox sensors uncover oxidative stress as an early event in life. Mol Cell. 2012;47(5):767–76. https://doi.org/10.1016/j.molcel.2012.06.016.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Back P, Matthijssens F, Vanfleteren JR, Braeckman BP. A simplified hydroethidine method for fast and accurate detection of superoxide production in isolated mitochondria. Anal Biochem. 2012;423(1):147–51. https://doi.org/10.1016/j.ab.2012.01.008.