Basbaum AI, Bautista DM, Scherrer G, Julius D (2009) Cellular and molecular mechanisms of pain. Cell 139:267–284. https://doi.org/10.1016/j.cell.2009.09.028

Article  PubMed  PubMed Central  CAS  Google Scholar 

Dubin AE, Patapoutian A (2010) Nociceptors: the sensors of the pain pathway. J Clin Investig 120:3760. https://doi.org/10.1172/JCI42843

Article  PubMed  PubMed Central  CAS  Google Scholar 

Catterall WA (2011) Voltage-Gated calcium channels. Cold Spring Harb Perspect Biol 3:a003947. https://doi.org/10.1101/cshperspect.a003947

Article  PubMed  PubMed Central  CAS  Google Scholar 

Cooper D, Dimri M (2024) Biochemistry, calcium channels. In: StatPearls. StatPearls Publishing, Treasure Island (FL)

Google Scholar 

Zamponi GW, Lewis RJ, Todorovic SM et al (2009) Role of voltage-gated calcium channels in ascending pain pathways. Brain Res Rev 60:84–89. https://doi.org/10.1016/j.brainresrev.2008.12.021

Article  PubMed  CAS  Google Scholar 

Krarup C (2003) An update on electrophysiological studies in neuropathy. Curr Opin Neurol 16:603–612. https://doi.org/10.1097/01.wco.0000093104.34793.94

Article  PubMed  Google Scholar 

Julius D, Basbaum AI (2001) Molecular mechanisms of nociception. Nature 413:203–210. https://doi.org/10.1038/35093019

Article  PubMed  CAS  Google Scholar 

Jacus MO, Uebele VN, Renger JJ, Todorovic SM (2012) Presynaptic CaV3.2 channels regulate excitatory neurotransmission in nociceptive dorsal Horn neurons. J Neurosci 32:9374–9382. https://doi.org/10.1523/JNEUROSCI.0068-12.2012

Article  PubMed  PubMed Central  CAS  Google Scholar 

Mesirca P, Chemin J, Barrère C et al (2024) Selective Blockade of Cav1.2 (α1C) versus Cav1.3 (α1D) L-type calcium channels by the black Mamba toxin calciseptine. Nat Commun 15:54. https://doi.org/10.1038/s41467-023-43502-w

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ferron L, Harding EK, Gandini MA et al (2024) Functional remodeling of presynaptic voltage-gated calcium channels in superficial layers of the dorsal Horn during neuropathic pain. https://doi.org/10.1016/j.isci.2024.109973. iScience 27:

Gong N, Park J, Luo ZD (2018) Injury-induced maladaptation and dysregulation of calcium channel α2δ subunit proteins and its contribution to neuropathic pain development. Br J Pharmacol 175:2231–2243. https://doi.org/10.1111/bph.13930

Article  PubMed  CAS  Google Scholar 

Vink S, Alewood P (2012) Targeting voltage-gated calcium channels: developments in peptide and small‐molecule inhibitors for the treatment of neuropathic pain. Br J Pharmacol 167:970–989. https://doi.org/10.1111/j.1476-5381.2012.02082.x

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lee S (2013) Pharmacological Inhibition of Voltage-gated Ca2 + Channels for chronic pain relief. Curr Neuropharmacol 11:606–620. https://doi.org/10.2174/1570159X11311060005

Article  PubMed  PubMed Central  CAS  Google Scholar 

Fink K, Meder W, Dooley DJ, Göthert M (2000) Inhibition of neuronal Ca2 + influx by Gabapentin and subsequent reduction of neurotransmitter release from rat neocortical slices. Br J Pharmacol 130:900–906. https://doi.org/10.1038/sj.bjp.0703380

Article  PubMed  PubMed Central  CAS  Google Scholar 

Brawek B, Löffler M, Dooley DJ et al (2008) Differential modulation of K(+)-evoked (3)H-neurotransmitter release from human neocortex by Gabapentin and Pregabalin. Naunyn Schmiedebergs Arch Pharmacol 376:301–307. https://doi.org/10.1007/s00210-007-0237-8

Article  PubMed  CAS  Google Scholar 

Wittenburg N, Baumeister R (1999) Thermal avoidance in Caenorhabditis elegans: an approach to the study of nociception. Proc Natl Acad Sci USA 96:10477. https://doi.org/10.1073/pnas.96.18.10477

Article  PubMed  PubMed Central  CAS  Google Scholar 

Glauser DA, Chen WC, Agin R et al (2011) Heat avoidance is regulated by transient receptor potential (TRP) channels and a neuropeptide signaling pathway in Caenorhabditis elegans. Genetics 188:91–103. https://doi.org/10.1534/genetics.111.127100

Article  PubMed  PubMed Central  CAS  Google Scholar 

Mohammadi A, Byrne Rodgers J, Kotera I, Ryu WS (2013) Behavioral response of Caenorhabditis elegans to localized thermal stimuli. BMC Neurosci 14:66. https://doi.org/10.1186/1471-2202-14-66

Article  PubMed  PubMed Central  Google Scholar 

Kotera I, Tran NA, Fu D et al (2016) Pan-neuronal screening in Caenorhabditis elegans reveals asymmetric dynamics of AWC neurons is critical for thermal avoidance behavior. eLife 5:e19021. https://doi.org/10.7554/eLife.19021

Article  PubMed  PubMed Central  CAS  Google Scholar 

Goodman MB, Sengupta P (2019) How Caenorhabditis elegans senses mechanical stress, temperature, and other physical stimuli. Genetics 212:25–51. https://doi.org/10.1534/genetics.118.300241

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lai C-H, Chou C-Y, Ch’ang L-Y et al (2000) Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. Genome Res 10:703–713. https://doi.org/10.1101/gr.10.5.703

Article  PubMed  PubMed Central  CAS  Google Scholar 

Harris TW, Chen N, Cunningham F et al (2004) WormBase: a multi-species resource for nematode biology and genomics. Nucleic Acids Res 32:D411–D417. https://doi.org/10.1093/nar/gkh066

Article  PubMed  PubMed Central  CAS  Google Scholar 

Hobert O (2018) The neuronal genome of Caenorhabditis elegans. In: WormBook: The Online Review of C. elegans Biology [Internet]. WormBook

Mathews EA, García E, Santi CM et al (2003) Critical residues of the Caenorhabditis elegans unc-2 Voltage-Gated calcium channel that affect behavioral and physiological properties. J Neurosci 23:6537–6545. https://doi.org/10.1523/JNEUROSCI.23-16-06537.2003

Article  PubMed  PubMed Central  CAS  Google Scholar 

Caylor RC, Jin Y, Ackley BD (2013) The Caenorhabditis elegans voltage-gated calcium channel subunits UNC-2 and UNC-36 and the calcium-dependent kinase UNC-43/CaMKII regulate neuromuscular junction morphology. Neural Dev 8:10. https://doi.org/10.1186/1749-8104-8-10

Article  PubMed  PubMed Central  CAS  Google Scholar 

Nkambeu B, Salem JB, Beaudry F (2020) Capsaicin and its analogues impede nocifensive response of Caenorhabditis elegans to noxious heat. Neurochem Res 45:1851–1859. https://doi.org/10.1007/s11064-020-03049-4

Article  PubMed  CAS  Google Scholar 

Salem JB, Nkambeu B, Arvanitis DN, Beaudry F (2022) Resiniferatoxin hampers the nocifensive response of Caenorhabditis elegans to noxious heat, and pathway analysis revealed that the Wnt signaling pathway is involved. Neurochem Res 47:622–633. https://doi.org/10.1007/s11064-021-03471-2

Article  PubMed  CAS  Google Scholar 

Boujenoui F, Nkambeu B, Salem JB et al (2024) Cannabidiol and tetrahydrocannabinol antinociceptive activity is mediated by distinct receptors in Caenorhabditis elegans. Neurochem Res 49:935–948. https://doi.org/10.1007/s11064-023-04069-6

Article  PubMed  CAS  Google Scholar 

Abdollahi M, Castaño JD, Salem JB, Beaudry F (2024) Anandamide modulates thermal avoidance in Caenorhabditis elegans through vanilloid and cannabinoid receptor interplay. Neurochem Res 49:2423–2439.