Harnessing Endogenous Neural Stem Cells: A New Frontier in Spinal Cord Injury Repair

Lin J, Sun Y, Xia B, Wang Y, Xie C, Wang J, Hu J, Zhu L (2024) Mertk reduces blood-spinal cord barrier permeability through the Rhoa/Rock1/P-MLC pathway after spinal cord injury. Neurosci Bull 40:1230–1244. https://doi.org/10.1007/s12264-024-01199-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang YT, Yuan H (2022) Research progress of endogenous neural stem cells in spinal cord injury. Ibrain 8:199–209. https://doi.org/10.1002/ibra.12048

Article  PubMed  PubMed Central  Google Scholar 

Gao Z, Pang Z, Chen Y, Lei G, Zhu S, Li G, Shen Y, Xu W (2022) Restoring after central nervous system injuries: neural mechanisms and translational applications of motor recovery. Neurosci Bull 38:1569–1587. https://doi.org/10.1007/s12264-022-00959-x

Article  PubMed  PubMed Central  Google Scholar 

Zhang S, Chen Y, Wang Y, Wang H, Yao D, Chen G (2024) Tau accumulation in the spinal cord contributes to chronic inflammatory pain by upregulation of IL-1β and BDNF. Neurosci Bull 40:466–482. https://doi.org/10.1007/s12264-023-01152-4

Article  CAS  PubMed  Google Scholar 

Jiang B, Sun D, Sun H, Ru X, Liu H, Ge S, Fu J, Wang W (2021) Prevalence, incidence, and external causes of traumatic spinal cord injury in China: a nationally representative cross-sectional survey. Front Neurol 12:784647. https://doi.org/10.3389/fneur.2021.784647

Article  PubMed  Google Scholar 

Rodriguez-Jimenez FJ, Jendelova P, Erceg S (2023) The activation of dormant ependymal cells following spinal cord injury. Stem Cell Res Ther 14:175. https://doi.org/10.1186/s13287-023-03395-4

Article  PubMed  PubMed Central  Google Scholar 

Li J, Luo W, Xiao C, Zhao J, Xiang C, Liu W, Gu R (2023) Recent advances in endogenous neural stem/progenitor cell manipulation for spinal cord injury repair. Theranostics 13:3966–3987. https://doi.org/10.7150/thno.84133

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ge M, Sheikhshahrokh A, Shi X, Zhang YH, Xu Z, Wu QF (2023) A spacetime odyssey of neural progenitors to generate neuronal diversity. Neurosci Bull 39:645–658. https://doi.org/10.1007/s12264-022-00956-0

Article  PubMed  Google Scholar 

Li Y, He J (2024) Neural stem cell competition. Neurosci Bull 40:277–279. https://doi.org/10.1007/s12264-023-01121-x

Article  PubMed  Google Scholar 

Hamilton LK, Truong MK, Bednarczyk MR, Aumont A, Fernandes KJ (2009) Cellular organization of the central canal ependymal zone, a niche of latent neural stem cells in the adult mammalian spinal cord. Neuroscience 164:1044–1056. https://doi.org/10.1016/j.neuroscience.2009.09.006

Article  CAS  PubMed  Google Scholar 

Qin Y, Zhang W, Yang P (2015) Current states of endogenous stem cells in adult spinal cord. J Neurosci Res 93:391–398. https://doi.org/10.1002/jnr.23480

Article  CAS  PubMed  Google Scholar 

Bai Y, Ren H, Bian L, Zhou Y, Wang X, Xiong Z, Liu Z, Han B et al (2023) Regulation of glial function by noncoding RNA in central nervous system disease. Neurosci Bull 39:440–452. https://doi.org/10.1007/s12264-022-00950-6

Article  CAS  PubMed  Google Scholar 

Xia Y, Ding L, Zhang C, Xu Q, Shi M, Gao T, Zhou FQ, Deng DYB (2024) Inflammatory factor IL1α induces aberrant astrocyte proliferation in spinal cord injury through the Grin2c/Ca(2+)/CaMK2b pathway. Neurosci Bull 40:421–438. https://doi.org/10.1007/s12264-023-01128-4

Article  CAS  PubMed  Google Scholar 

Kang SH, Fukaya M, Yang JK, Rothstein JD, Bergles DE (2010) NG2 + CNS glial progenitors remain committed to the oligodendrocyte lineage in postnatal life and following neurodegeneration. Neuron 68:668–681. https://doi.org/10.1016/j.neuron.2010.09.009

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tai W, Wu W, Wang LL, Ni H, Chen C, Yang J, Zang T, Zou Y et al (2021) In vivo reprogramming of NG2 glia enables adult neurogenesis and functional recovery following spinal cord injury. Cell Stem Cell 28:923–937. https://doi.org/10.1016/j.stem.2021.02.009

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tripathi RB, Rivers LE, Young KM, Jamen F, Richardson WD (2010) NG2 glia generate new oligodendrocytes but few astrocytes in a murine experimental autoimmune encephalomyelitis model of demyelinating disease. J Neurosci 30:16383–16390. https://doi.org/10.1523/jneurosci.3411-10.2010

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barnabé-Heider F, Göritz C, Sabelström H, Takebayashi H, Pfrieger FW, Meletis K, Frisén J (2010) Origin of new glial cells in intact and injured adult spinal cord. Cell Stem Cell 7:470–482. https://doi.org/10.1016/j.stem.2010.07.014

Article  CAS  PubMed  Google Scholar 

Meletis K, Barnabé-Heider F, Carlén M, Evergren E, Tomilin N, Shupliakov O, Frisén J (2008) Spinal cord injury reveals multilineage differentiation of ependymal cells. PLoS Biol 6:e182. https://doi.org/10.1371/journal.pbio.0060182

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cawsey T, Duflou J, Weickert CS, Gorrie CA (2015) Nestin-positive ependymal cells are increased in the human spinal cord after traumatic central nervous system injury. J Neurotrauma 32:1393–1402. https://doi.org/10.1089/neu.2014.3575

Article  PubMed  PubMed Central  Google Scholar 

Moreno-Manzano V, Rodríguez-Jiménez FJ, García-Roselló M, Laínez S, Erceg S, Calvo MT, Ronaghi M, Lloret M et al (2009) Activated spinal cord ependymal stem cells rescue neurological function. Stem Cells 27:733–743. https://doi.org/10.1002/stem.24

Article  CAS  PubMed  Google Scholar 

Becker CG, Becker T (2015) Neuronal regeneration from ependymo-radial glial cells: cook, little pot, cook! Dev Cell 32:516–527. https://doi.org/10.1016/j.devcel.2015.01.001

Article  CAS  PubMed  Google Scholar 

Saker E, Henry BM, Tomaszewski KA, Loukas M, Iwanaga J, Oskouian RJ, Tubbs RS (2016) The human central canal of the spinal cord: a comprehensive review of its anatomy, embryology, molecular development, variants, and pathology. Cureus 8:e927. https://doi.org/10.7759/cureus.927

Article  PubMed  PubMed Central  Google Scholar 

Spassky N, Merkle FT, Flames N, Tramontin AD, García-Verdugo JM, Alvarez-Buylla A (2005) Adult ependymal cells are postmitotic and are derived from radial glial cells during embryogenesis. J Neurosci 25:10–18. https://doi.org/10.1523/jneurosci.1108-04.2005

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fu H, Qi Y, Tan M, Cai J, Hu X, Liu Z, Jensen J, Qiu M (2003) Molecular mapping of the origin of postnatal spinal cord ependymal cells: evidence that adult ependymal cells are derived from Nkx6.1 + ventral neural progenitor cells. J Comp Neurol 456:237–244. https://doi.org/10.1002/cne.10481

Article  CAS  PubMed  Google Scholar 

Vladar EK, Mitchell BJ (2016) It’s a family act: the Geminin triplets take center stage in motile ciliogenesis. EMBO J 35:904–906. https://doi.org/10.15252/embj.201694206

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kyrousi C, Lygerou Z, Taraviras S (2017) How a radial glial cell decides to become a multiciliated ependymal cell. Glia 65:1032–1042. https://doi.org/10.1002/glia.23118

Article  PubMed  Google Scholar 

Zeisel A, Muñoz-Manchado AB, Codeluppi S, Lönnerberg P, La Manno G, Juréus A, Marques S, Munguba H et al (2015) Brain structure. Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq. Science 347:1138–1142. https://doi.org/10.1126/science.aaa1934

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