Wang Z, Mascarenhas C, Jia X (2020) Positron emission tomography after ischemic brain injury: current challenges and future developments. Translational Stroke Res 11:628–642. https://doi.org/10.1007/s12975-019-00765-0

Article  CAS  Google Scholar 

Herpich F, Rincon F (2020) Management of acute ischemic stroke. Crit Care Med 48:1654–1663. https://doi.org/10.1097/ccm.0000000000004597

Article  PubMed  PubMed Central  Google Scholar 

Kriska J, Hermanova Z, Knotek T, Tureckova J, Anderova M (2021) On the common journey of neural cells through ischemic brain injury and alzheimer’s disease. Int J Mol Sci 22(18):9689. https://doi.org/10.3390/ijms22189689

Article  CAS  PubMed  PubMed Central  Google Scholar 

Morris-Blanco KC, Chokkalla AK, Kim T, Bhatula S, Bertogliat MJ, Gaillard AB, Vemuganti R (2022) High-Dose vitamin C prevents secondary brain damage after stroke via epigenetic reprogramming of neuroprotective genes. Translational Stroke Res 13:1017–1036. https://doi.org/10.1007/s12975-022-01007-6

Article  CAS  Google Scholar 

Bertogliat MJ, Morris-Blanco KC, Vemuganti R (2020) Epigenetic mechanisms of neurodegenerative diseases and acute brain injury. Neurochem Int 133:104642. https://doi.org/10.1016/j.neuint.2019.104642

Article  CAS  PubMed  Google Scholar 

Heinsberg LW, Weeks DE, Alexander SA, Minster RL, Sherwood PR, Poloyac SM, Deslouches S, Crago EA, Conley YP (2021) Iron homeostasis pathway DNA methylation trajectories reveal a role for STEAP3 metalloreductase in patient outcomes after aneurysmal subarachnoid hemorrhage. Epigenetics Commun 1:4. https://doi.org/10.1186/s43682-021-00003-5

Article  PubMed  PubMed Central  Google Scholar 

Wang H, Xu Y, Zhu S, Li X, Zhang H (2021) Post-Treatment Sevoflurane protects against Hypoxic-Ischemic brain injury in neonatal rats by downregulating histone methyltransferase G9a and upregulating nuclear factor erythroid 2-Related factor 2 (NRF2). Med Sci Monitor: Int Med J Experimental Clin Res 27:e930042. https://doi.org/10.12659/msm.930042

Article  CAS  Google Scholar 

Bellver-Sanchis A, Geng Q, Navarro G, Ávila-López PA, Companys-Alemany J, Marsal-García L, Larramona-Arcas R, Miró L, Perez-Bosque A, Ortuño-Sahagún D, Banerjee DR, Choudhary BS, Soriano FX, Poulard C, Pallàs M, Du HN, Griñán-Ferré C (2024) G9a Inhibition promotes neuroprotection through GMFB regulation in alzheimer’s disease. Aging Disease 15:311–337. https://doi.org/10.14336/ad.2023.0424-2

Article  PubMed  PubMed Central  Google Scholar 

Guan Y, Cao YL, Liu JW, Liu LT, Zheng YJ, Ma XF, Zhai FG (2023) Ginsenoside Rg1 attenuates cerebral ischemia-reperfusion injury through inhibiting the inflammatory activation of microglia. Exp Cell Res 426:113552. https://doi.org/10.1016/j.yexcr.2023.113552

Article  CAS  PubMed  Google Scholar 

Sui H, Sun Z, Liu C, Xi H (2025) Ferritinophagy promotes microglia ferroptosis to aggravate neuroinflammation induced by cerebral ischemia-reperfusion injury via activation of the cGAS-STING signaling pathway. Neurochem Int 183:105920. https://doi.org/10.1016/j.neuint.2024.105920

Article  CAS  PubMed  Google Scholar 

Peng L, Hu G, Yao Q, Wu J, He Z, Law BY, Hu G, Zhou X, Du J, Wu A, Yu L (2022) Microglia autophagy in ischemic stroke: a double-edged sword. Front Immunol 13:1013311. https://doi.org/10.3389/fimmu.2022.1013311

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fan W, Chen H, Li M, Fan X, Jiang F, Xu C, Wang Y, Wei W, Song J, Zhong D, Li G (2024) NRF2 activation ameliorates blood-brain barrier injury after cerebral ischemic stroke by regulating ferroptosis and inflammation. Sci Rep 14:5300. https://doi.org/10.1038/s41598-024-53836-0

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guo D, Ma J, Li T, Yan L (2018) Up-regulation of miR-122 protects against neuronal cell death in ischemic stroke through the heat shock protein 70-dependent NF-κB pathway by targeting FOXO3. Exp Cell Res 369:34–42. https://doi.org/10.1016/j.yexcr.2018.04.027

Article  CAS  PubMed  Google Scholar 

Wang H, Li Y, Jiang S, Liu N, Zhou Q, Li Q, Chen Z, Lin Y, Chen C, Deng Y (2023) LncRNA Xist regulates sepsis associated neuroinflammation in the periventricular white matter of CLP rats by miR-122-5p/PKCη axis. Front Immunol 14:1225482. https://doi.org/10.3389/fimmu.2023.1225482

Article  CAS  PubMed Central  Google Scholar 

Wang Y, Zhao H, Guo M, Fei D, Zhang L, Xing M (2020) Targeting the miR-122/PKM2 autophagy axis relieves arsenic stress. J Hazard Mater 383:121217. https://doi.org/10.1016/j.jhazmat.2019.121217

Article  CAS  PubMed  Google Scholar 

Gupta-Agarwal S, Franklin AV, Deramus T, Wheelock M, Davis RL, McMahon LL, Lubin FD (2012) G9a/GLP histone lysine dimethyltransferase complex activity in the hippocampus and the entorhinal cortex is required for gene activation and Silencing during memory consolidation. J Neuroscience: Official J Soc Neurosci 32:5440–5453. https://doi.org/10.1523/jneurosci.0147-12.2012

Article  CAS  Google Scholar 

Yuan LT, Lee WJ, Yang YC, Chen BR, Yang CY, Chen MW, Chen JQ, Hsiao M, Chien MH, Hua KT (2021) Histone methyltransferase G9a-Promoted progression of hepatocellular carcinoma is targeted by Liver-Specific Hsa-miR-122. Cancers 13(10):2376. https://doi.org/10.3390/cancers13102376

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen TQ, Hu N, Huo B, Masau JF, Yi X, Zhong XX, Chen YJ, Guo X, Zhu XH, Wei X, Jiang DS (2020) EHMT2/G9a inhibits aortic smooth muscle cell death by suppressing autophagy activation. Int J Biol Sci 16:1252–1263. https://doi.org/10.7150/ijbs.38835

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rothammer N, Woo MS, Bauer S, Binkle-Ladisch L, Di Liberto G, Egervari K, Wagner I, Haferkamp U, Pless O, Merkler D, Engler JB, Friese MA (2022) G9a dictates neuronal vulnerability to inflammatory stress via transcriptional control of ferroptosis. Sci Adv 8:eabm5500. https://doi.org/10.1126/sciadv.abm5500

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lisek M, Bochenska N, Tomczak J, Duraj J, Boczek T (2025) Epigenetic regulation in ischemic neuroprotection: the dual role of HDACs and hats in neuroinflammation and recovery. Antioxid (Basel Switzerland) 14(8):1015. https://doi.org/10.3390/antiox14081015

Article  CAS  Google Scholar 

Xu G, Zhang J, Shao C, Wu H, Li C, Yu L, Zhou H, An H, Wang T, Pu J, Yang J, Wan H (2025) Puerarin alleviates cerebral ischemia/reperfusion (CIR)-induced neurocyte oxidative stress and apoptosis via DNA demethylation-mediated PI3K/Akt activation. Phytomedicine: Int J Phytotherapy Phytopharmacology 145:157094. https://doi.org/10.1016/j.phymed.2025.157094

Article  CAS  Google Scholar 

Zhou T, Zhang L, He L, Lan Y, Ding L, Li L, Wang Z (2024) GSK-126 attenuates cell apoptosis in ischemic brain injury by modulating the EZH2-H3K27me3-Bcl2l1 axis. Mol Neurobiol 61:3369–3383. https://doi.org/10.1007/s12035-023-03808-8

Article  CAS  PubMed  Google Scholar 

Hsu CM, Chang KC, Chuang TM, Chu ML, Lin PW, Liu HS, Kao SY, Liu YC, Huang CT, Wang MH, Yeh TJ, Gau YC, Du JS, Wang HC, Cho SF, Hsiao CE, Tsai Y, Hsiao SY, Hung LC, Yen CH, Hsiao HH (2023) High G9a expression in DLBCL and its Inhibition by niclosamide to induce autophagy as a therapeutic approach. Cancers 15(16):4150. https://doi.org/10.3390/cancers15164150

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li M, Meng Z, Yu S, Li J, Wang Y, Yang W, Wu H (2022) Baicalein ameliorates cerebral ischemia-reperfusion injury by inhibiting ferroptosis via regulating GPX4/ACSL4/ACSL3 axis. Chemico-Biol Interact 366:110137. https://doi.org/10.1016/j.cbi.2022.110137

Article  CAS  Google Scholar 

Wang Q, Liu C, Chen M, Zhao J, Wang D, Gao P, Zhang C, Zhao H (2024) Mastoparan M promotes functional recovery in stroke mice by activating autophagy and inhibiting ferroptosis. Biomed pharmacotherapy = Biomedecine Pharmacotherapie 174:116560. https://doi.org/10.1016/j.biopha.2024.116560

Article  CAS  PubMed  Google Scholar 

Chen G, Wang X, Jin Z, Hu GB, Yu QH, Jiang HY (2024) HIF-1α knockdown attenuates inflammation and oxidative stress in ischemic stroke male rats via CXCR4/NF-κB pathway. Brain Behav 14:e70039. https://doi.org/10.1002/brb3.70039

Article  CAS  PubMed  PubMed Central