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Exploring the Therapeutic Potential of N-(3,4-dimethoxy phenyl)-6,7-dimethoxyquinazoline-4-amine (TKM01) in Aluminium-Induced Alzheimer’s Disease-Like Model of Zebrafish
Exploring the Therapeutic Potential of N-(3,4-dimethoxy phenyl)-6,7-dimethoxyquinazoline-4-amine (TKM01) in Aluminium-Induced Alzheimer’s Disease-Like Model of Zebrafish
Aluminum (Al), a pervasive environmental neurotoxicant, has been strongly implicated in the onset and progression of Alzhe...
Nuclear and Cytoplasmic Mouse ID Associated 1 (MIDA1) Protein Varies in Neurons and Astrocytes Across the Different Hippocampal Regions and Exhibits Age-Related Changes
Nuclear and Cytoplasmic Mouse ID Associated 1 (MIDA1) Protein Varies in Neurons and Astrocytes Across the Different Hippocampal Regions and Exhibits Age-Related Changes
Nuclear Mouse ID Associated 1 (MIDA1), also known as Hsp40/DNAJC2 and ZRF1, plays a key role in the establishment of neura...
Plasma-Derived Exosomal hsa-miR-3677-3p Induces Ferroptosis in Neurons by Targeting in Perioperative Neurocognitive Disorders After Prostate Surgery
Plasma-Derived Exosomal hsa-miR-3677-3p Induces Ferroptosis in Neurons by Targeting in Perioperative Neurocognitive Disorders After Prostate Surgery
Perioperative neurocognitive disorders (PND) are prevalent complications in elderly patients following surgery, characteri...
Noninvasive Focused Ultrasound as a Safe Modulator of Calcium-Dependent Neurochemical Signalling in Primary Cortical Cultures
Noninvasive Focused Ultrasound as a Safe Modulator of Calcium-Dependent Neurochemical Signalling in Primary Cortical Cultures
Focused ultrasound stimulation (FUS) is a promising non-invasive neuromodulation technique that can influence neuronal act...
Metformin Ameliorates Cognitive Deficits and Neuroinflammation in a Mouse Model of Familial Hypercholesterolemia
Metformin Ameliorates Cognitive Deficits and Neuroinflammation in a Mouse Model of Familial Hypercholesterolemia
Familial hypercholesterolemia (FH), caused by mutations in the low-density lipoprotein receptor (LDLr) gene, has been incr...
The Cell-Specific Effects of the Human Remyelination-Promoting rHIgM22 on Sphingolipid Metabolism in Cultured Glial Cells
The Cell-Specific Effects of the Human Remyelination-Promoting rHIgM22 on Sphingolipid Metabolism in Cultured Glial Cells
Demyelinating diseases are heterogeneous in their etiology, clinical course, and manifestations. In the long run, however,...
Harnessing Endogenous Neural Stem Cells: A New Frontier in Spinal Cord Injury Repair
Harnessing Endogenous Neural Stem Cells: A New Frontier in Spinal Cord Injury Repair
Spinal cord injury (SCI), a serious neurological condition caused by trauma, inflammation, infection, or vascular diseases...
Ciprofol Promotes SIRT1-Mediated Raf Regulation of ERK1/2 Hyperphosphorylation
Ciprofol Promotes SIRT1-Mediated Raf Regulation of ERK1/2 Hyperphosphorylation
Epilepsy (EP) is characterized by sudden abnormal discharges of neurons in the brain. Its complex pathological mechanisms ...
G9a Targeting by miR-122 Ameliorates Ischemic Brain Injury via Enhanced Microglial Autophagy and Suppressed Ferroptosis
G9a Targeting by miR-122 Ameliorates Ischemic Brain Injury via Enhanced Microglial Autophagy and Suppressed Ferroptosis
Microglia are crucial in ischemic brain injury (IBI). Modulating microglial autophagy and inhibiting ferroptosis via miR-1...
Centratherin Exhibits Antitumor Activity Against Glioblastoma Cells
Centratherin Exhibits Antitumor Activity Against Glioblastoma Cells
Glioblastoma (GB) is the most aggressive and lethal primary brain tumor, characterized by high proliferative, migratory, a...
HCG18 is a Potential Pathogenic Factor and Diagnostic Biomarker Alzheimer’s Disease
HCG18 is a Potential Pathogenic Factor and Diagnostic Biomarker Alzheimer’s Disease
Alzheimer’s disease (AD), a major neurodegenerative disorder, lacks effective early diagnostic and therapeutic strat...
Decanoic Acid Treatment Alleviates Non-cell Autonomous Transfer of HD Pathology by Secretome of Mutant Huntingtin Expressing Cells
Decanoic Acid Treatment Alleviates Non-cell Autonomous Transfer of HD Pathology by Secretome of Mutant Huntingtin Expressing Cells
Huntington’s disease (HD) is a fatal neurodegenerative disorder marked by progressive neuronal loss with prominent d...
4-Phenylbutyrate Induces Functional Elongation of the Microglial Process Through Activation of Akt
4-Phenylbutyrate Induces Functional Elongation of the Microglial Process Through Activation of Akt
Conversion of microglia to a branching state is considered a potential strategy to ameliorate neuroinflammation. Inhibitio...
MARCH6 Confers Protection Against Endoplasmic Reticulum Autophagy in Gliomas by Destabilizing FAM134B
MARCH6 Confers Protection Against Endoplasmic Reticulum Autophagy in Gliomas by Destabilizing FAM134B
This study probed the mechanism of MARCH6 in endoplasmic reticulum autophagy (ER-phagy) during glioma development by regul...
Glucocorticoid-Mediated Astrocytic -Lactate Release Drives Chronic Postsurgical Pain via Spinal Neuronal Sensitization
Glucocorticoid-Mediated Astrocytic -Lactate Release Drives Chronic Postsurgical Pain via Spinal Neuronal Sensitization
Chronic post-surgical pain (CPSP) in rats is characterized by persistent mechanical allodynia and spinal neuronal hypersen...
Contextual Fear Conditioning Selectively Increases Levels of Arc and c-Fos Proteins in the Dorsal, but not the Ventral Hippocampus
Contextual Fear Conditioning Selectively Increases Levels of Arc and c-Fos Proteins in the Dorsal, but not the Ventral Hippocampus
The hippocampus plays an important role in contextual fear-conditioning and exhibits functional specialization along its d...
Integrative Analysis of Trace Elements, Oxidative Stress, and Psychological Distress in Epilepsy: Biochemical Profiling and In Silico Docking Insights
Integrative Analysis of Trace Elements, Oxidative Stress, and Psychological Distress in Epilepsy: Biochemical Profiling and In Silico Docking Insights
Epilepsy is a complex neurological disorder shaped by oxidative stress, imbalances in trace elements, and psychological di...
AQP4-IgG-Induced Astrocyte-Derived Small Extracellular Vesicles Carrying Mitochondrial DNA Regulate the TLR9/MyD88/NF-κB Pathway to Drive Microglial Activation and Neuromyelitis Optica
AQP4-IgG-Induced Astrocyte-Derived Small Extracellular Vesicles Carrying Mitochondrial DNA Regulate the TLR9/MyD88/NF-κB Pathway to Drive Microglial Activation and Neuromyelitis Optica
Neuromyelitis optica spectrum disorder (NMOSD) is a rare but serious inflammatory demyelinating disease. A key characteris...
Salidroside Exerts Neuroprotective Effects via Inhibiting Ferroptosis in Mice with Traumatic Brain Injury
Salidroside Exerts Neuroprotective Effects via Inhibiting Ferroptosis in Mice with Traumatic Brain Injury
Traumatic brain injury (TBI) carries a high incidence of morbidity and mortality worldwide. We aim to explore the neuropro...
Astragaloside’s Role in Microglial Neuroinflammation: A Multi-Method Study Combining Experimental and Computational Analyses
Astragaloside’s Role in Microglial Neuroinflammation: A Multi-Method Study Combining Experimental and Computational Analyses
This study investigates the mechanism by which astragaloside (AST) modulates microglial metabolism to alleviate inflammato...
The Endocannabinoid System in Retinal Müller Glia: Lessons From Astrocyte Research
The Endocannabinoid System in Retinal Müller Glia: Lessons From Astrocyte Research
The endocannabinoid system (ECS) is a widespread neuromodulatory system involved in both physiological and pathological pr...
Possible Mitigating Effect of Nobiletin on Rotenone–Induced Parkinsonism in Male Albino Rat Model: Targeting Bmal1/Nrf2 Mediated Ferroptosis and Restoring Mitochondrial Mitophagy
Possible Mitigating Effect of Nobiletin on Rotenone–Induced Parkinsonism in Male Albino Rat Model: Targeting Bmal1/Nrf2 Mediated Ferroptosis and Restoring Mitochondrial Mitophagy
Ferroptosis and circadian disruption might be implicated in Parkinson disease (PD), a neurodegenerative disorder due to de...
Inhibition of Rac1 Attenuated Propofol-Induced Neurotoxicity in the Hippocampal Dentate Gyrus in Developing Mice
Inhibition of Rac1 Attenuated Propofol-Induced Neurotoxicity in the Hippocampal Dentate Gyrus in Developing Mice
Accumulating evidence from animals has shown that multiple exposures to general anesthetics during brain development may c...
Emerging Insights into the Pathogenic Mechanisms of Dravet Syndrome
Emerging Insights into the Pathogenic Mechanisms of Dravet Syndrome
Dravet syndrome (DS) is a rare monogenic developmental and epileptic encephalopathy (DEE) most frequently caused by SCN1A ...
Targeting Fyn Kinase for Alleviation of Cognitive Impairment in Streptozocin-Induced Alzheimer’s Disease in Mice by Loperamide; An Experimental and in Silico Analysis
Targeting Fyn Kinase for Alleviation of Cognitive Impairment in Streptozocin-Induced Alzheimer’s Disease in Mice by Loperamide; An Experimental and in Silico Analysis
Alzheimer’s disease (AD) is a complex, progressive neurodegenerative disorder that leads to irreversible deteriorati...
Genotype Impacts Polyunsaturated Neutral Lipid Storage and Ferroptosis Vulnerability in Astrocytes
Genotype Impacts Polyunsaturated Neutral Lipid Storage and Ferroptosis Vulnerability in Astrocytes
Astrocytes play a critical role in regulating the metabolism of cholesterol and other lipids in the brain. Increasing evid...
Caveolin-1–Mediated Blood-Brain Barrier Disruption via MMP2/9 Contributes to Postoperative Cognitive Dysfunction
Caveolin-1–Mediated Blood-Brain Barrier Disruption via MMP2/9 Contributes to Postoperative Cognitive Dysfunction
Postoperative cognitive dysfunction (POCD) is a prevalent complication following major surgery, particularly in older adul...
Deficient Astrocyte Homeostatic Support Contributes to Brain Impairment in Duchenne Muscular Dystrophy
Deficient Astrocyte Homeostatic Support Contributes to Brain Impairment in Duchenne Muscular Dystrophy
In addition to their muscle functions, dystrophins -the protein products of the DMD gene - also play a role in the central...
Astrocytes Regulate Brain State Transitions
Astrocytes Regulate Brain State Transitions
We celebrate the life of our close friend and collaborator, Arne Schousboe, by writing this prose of the role of astrocyte...
Voltage-Gated Calcium Channels Play a Central Role in Response to Noxious Heat
Voltage-Gated Calcium Channels Play a Central Role in Response to Noxious Heat
Voltage-gated calcium channels (VGCCs) are critical for calcium ion influx during action potentials, playing a key role in...
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