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Glycosylation of FGFR4 in cholangiocarcinoma regulates receptor processing and cancer signaling
Glycosylation of FGFR4 in cholangiocarcinoma regulates receptor processing and cancer signaling
Abstract Recent advances in targeted treatment for cholangiocarcinoma have focused on fibroblast growth factor (FGF) signa...
Spinal malformation − A biochemical analysis using congenital kyphosis rats
Spinal malformation − A biochemical analysis using congenital kyphosis rats
Abstract Spinal kyphosis involves the vertebrae curving excessively backward, beyond their physiological curvature. Althou...
Suppression of transient receptor potential melastatin 7 regulates pluripotency, proliferation, and differentiation of mouse embryonic stem cells via mechanistic target of rapamycin‐extracellular signal‐regulated kinase activation
Suppression of transient receptor potential melastatin 7 regulates pluripotency, proliferation, and differentiation of mouse embryonic stem cells via mechanistic target of rapamycin‐extracellular signal‐regulated kinase activation
Abstract Mouse embryonic stem cells (mESCs) are a widely used model for their diverse availability in studying early embry...
The emerging role of selenium metabolic pathways in cancer: New therapeutic targets for cancer
The emerging role of selenium metabolic pathways in cancer: New therapeutic targets for cancer
Abstract Selenium (Se) is incorporated into the body via the selenocysteine (Sec) biosynthesis pathway, which is critical ...
Withdrawal
Withdrawal
Withdrawal: “Megakaryocytes Enhance Mesenchymal Stromal Cells Proliferation and Inhibit Differentiation”, by...
p65/RelA NF‐κB fragments generated by RIPK3 activity regulate tumorigenicity, cell metabolism, and stemness characteristics
p65/RelA NF‐κB fragments generated by RIPK3 activity regulate tumorigenicity, cell metabolism, and stemness characteristics
Abstract Receptor-interacting protein kinase 3 (RIPK3) can induce necroptosis, apoptosis, or cell proliferation and is sil...
Protein acetylation effects on enzyme activity and metabolic pathway fluxes
Protein acetylation effects on enzyme activity and metabolic pathway fluxes
Abstract Acetylation of proteins seems a widespread process found in the three domains of life. Several studies have shown...
Detection of sieric BAG3 in patients affected by cardiovascular diseases: State of art and perspectives
Detection of sieric BAG3 in patients affected by cardiovascular diseases: State of art and perspectives
Abstract BAG3 is highly expressed in the heart and its functions are essential in maintaining cardiac muscle cells homeost...
Diabetic kidney disease‐predisposing proinflammatory and profibrotic genes identified by weighted gene co‐expression network analysis (WGCNA)
Diabetic kidney disease‐predisposing proinflammatory and profibrotic genes identified by weighted gene co‐expression network analysis (WGCNA)
Abstract Diabetic kidney disease (DKD) is one of the most serious microvascular complications of diabetes. Despite enormou...
The prominence of potential biomarkers in the diagnosis and management of hepatocellular carcinoma: Current scenario and future anticipation
The prominence of potential biomarkers in the diagnosis and management of hepatocellular carcinoma: Current scenario and future anticipation
Abstract Hepatocellular carcinoma (HCC) is one of the most aggressive and truculent types of cancer. Early detection of HC...
Role of T‐box genes in cancer, epithelial‐mesenchymal transition, and cancer stem cells
Role of T‐box genes in cancer, epithelial‐mesenchymal transition, and cancer stem cells
Abstract Sharing a common DNA binding motif called T-box, transcription factor T-box gene family controls embryonic develo...
The potential role of miR‐1290 in cancer progression, diagnosis, prognosis, and treatment: An oncomiR or onco‐suppressor microRNA?
The potential role of miR‐1290 in cancer progression, diagnosis, prognosis, and treatment: An oncomiR or onco‐suppressor microRNA?
Abstract Cancer is one of the leading causes of death in humans because of the lack of early diagnosis, distant metastases...
Cover Image, Volume 122, Number 12, December 2021
Cover Image, Volume 122, Number 12, December 2021
Front Cover: The cover image is based on the Research Article Computational decomposition reveals reshaping of the SARS-Co...
Role of BAG3 in bovine Deltapapillomavirus‐mediated autophagy
Role of BAG3 in bovine Deltapapillomavirus‐mediated autophagy
Abstract Bovine Deltapapillomavirus genus (δPV), comprises four members that are highly pathogenic and are frequentl...
Retraction
Retraction
Retraction: “Silencing ARHGAP9 correlates with the risk of breast cancer and inhibits the proliferation, migration,...
Computational and in vitro validation of cardiogenic induction of quercetin on adipose‐derived mesenchymal stromal cells through the inhibition of Wnt and non‐Smad‐dependent TGF‐β pathways
Computational and in vitro validation of cardiogenic induction of quercetin on adipose‐derived mesenchymal stromal cells through the inhibition of Wnt and non‐Smad‐dependent TGF‐β pathways
Abstract Exploiting human mesenchymal stem cells (hMSCs) was proposed as a promising therapeutic approach for cardiovascul...
Understanding the impact of missense mutations on the structure and function of the EDA gene in X‐linked hypohidrotic ectodermal dysplasia: A bioinformatics approach
Understanding the impact of missense mutations on the structure and function of the EDA gene in X‐linked hypohidrotic ectodermal dysplasia: A bioinformatics approach
Abstract X-linked hypohidrotic dysplasia (XLHED), caused by mutations in the EDA gene, is a rare genetic disease that affe...
Fraxetin induces cell death in colon cancer cells via mitochondria dysfunction and enhances therapeutic effects in 5‐fluorouracil resistant cells
Fraxetin induces cell death in colon cancer cells via mitochondria dysfunction and enhances therapeutic effects in 5‐fluorouracil resistant cells
Abstract Fraxetin is a natural compound extracted from Fraxinus spp. and has various functions such as antibacterial, anti...
Genes controlling skeletal muscle glucose uptake and their regulation by endurance and resistance exercise
Genes controlling skeletal muscle glucose uptake and their regulation by endurance and resistance exercise
Abstract Exercise improves the insulin sensitivity of glucose uptake in skeletal muscle. Due to that, exercise has be...
3D‐QSAR, molecular docking, molecular dynamics, and ADME/T analysis of marketed and newly designed flavonoids as inhibitors of Bcl‐2 family proteins for targeting U‐87 glioblastoma
3D‐QSAR, molecular docking, molecular dynamics, and ADME/T analysis of marketed and newly designed flavonoids as inhibitors of Bcl‐2 family proteins for targeting U‐87 glioblastoma
Abstract Glioblastoma is the most common and destructive brain tumor with increasing complexity. Flavonoids are versatile ...
Review of cancer cell resistance mechanisms to apoptosis and actual targeted therapies
Review of cancer cell resistance mechanisms to apoptosis and actual targeted therapies
Abstract The apoptosis pathway is a programmed cell death mechanism that is crucial for cellular and tissue homeostasis an...
Methionine affects the expression of pluripotency genes and protein levels associated with methionine metabolism in adult, fetal, and cancer stem cells
Methionine affects the expression of pluripotency genes and protein levels associated with methionine metabolism in adult, fetal, and cancer stem cells
Abstract Intracellular and extracellular regulatory factors promote the potency and self-renewal property of stem cells. M...
SARS‐CoV‐2 spike evolutionary behaviors; simulation of N501Y mutation outcomes in terms of immunogenicity and structural characteristic
SARS‐CoV‐2 spike evolutionary behaviors; simulation of N501Y mutation outcomes in terms of immunogenicity and structural characteristic
Abstract Since the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a large number of mutat...
Myricetin inhibits breast and lung cancer cells proliferation via inhibiting MARK4
Myricetin inhibits breast and lung cancer cells proliferation via inhibiting MARK4
Abstract Identifying novel molecules as potential kinase inhibitors are gaining significant attention globally. The presen...
PAK1 and PAK2 in cell metabolism regulation
PAK1 and PAK2 in cell metabolism regulation
Abstract P21-activated kinases (PAKs) regulate processes associated with cytoskeletal rearrangements, such as cell divisio...
BAG3 induces α‐SMA expression in human fibroblasts and its over‐expression correlates with poorer survival in fibrotic cancer patients
BAG3 induces α‐SMA expression in human fibroblasts and its over‐expression correlates with poorer survival in fibrotic cancer patients
Abstract Hypoxia and angiogenesis in solid tumors are often strictly linked to the development of fibrotic tissues, a detr...
Understanding the binding mechanism for potential inhibition of SARS‐CoV‐2 Mpro and exploring the modes of ACE2 inhibition by hydroxychloroquine
Understanding the binding mechanism for potential inhibition of SARS‐CoV‐2 Mpro and exploring the modes of ACE2 inhibition by hydroxychloroquine
Abstract As per the World Health Organization report, around 226 844 344 confirmed positive cases and 4 ...
BAG3 induces fibroblasts to release key cytokines involved in pancreatic cell migration
BAG3 induces fibroblasts to release key cytokines involved in pancreatic cell migration
Abstract Pancreatic ductal adenoma carcinoma (PDAC) is considered one of the deadliest solid cancers as it is usually diag...
Immunoinformatics based designing a multi‐epitope vaccine against pathogenic Chandipura vesiculovirus
Immunoinformatics based designing a multi‐epitope vaccine against pathogenic Chandipura vesiculovirus
Abstract Chandipura vesiculovirus (CHPV) is a rapidly emerging pathogen responsible for causing acute encephalitis. Due to...
Protective effects of agrimonolide on hypoxia‐induced H9c2 cell injury by maintaining mitochondrial homeostasis
Protective effects of agrimonolide on hypoxia‐induced H9c2 cell injury by maintaining mitochondrial homeostasis
Abstract Cardiomyocyte death caused by hypoxia is one of the main causes of myocardial infarction or heart failure, and mi...
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