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Design, synthesis and anti-hepatocarcinoma activity of benzimidazole-fused carbazole derivatives by inducing PANoptosis
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Curculigoside suppresses glioblastoma progression through the EGFR/MMP2 axis: evidence from network pharmacology and experimental validation
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Development of Netrin-1-targeted peptide probes derived from the Netrin-1/DCC complex for noninvasive imaging of tumors
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Discovery of Emodin as a novel competitive KPC-2 inhibitor through virtual screening: Synergistic efficacy with Meropenem against Carbapenem-resistant Klebsiella pneumoniae infection
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Visualizing hydroxyl radical by a dual-channel NIR fluorescence chemosensor within biosystem
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Rapid discovery of novel spirobenzylisoquinoline alkaloids from Hypecoum erectum and their hepatoprotective activities
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Discovery of a new class based on 6-methoxypyrimidine as efficient low weight reversible inhibitors of SARS-CoV-2 main protease (Mpro) with antiviral activity
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Design, synthesis, molecular modeling, and evaluation of larvicidal efficacy of novel triazole derivatives against Culex pipiens L., referring to their potential mechanism
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Mesona chinensis Benth polyphenols ameliorate type 2 diabetes mellitus in mice through coordinated regulation of gut microbiota, metabolic profiles, and host metabolic-inflammatory responses
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New oxa/thiadiazole-chalcone hybrids linked via a clickable 1,2,3-triazole bridge with dual EGFR/VEGFR-2 kinase inhibitory activity and antiproliferative effects
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Quercetin attenuates polyethylene terephthalate nanoplastic-induced malignant phenotypes linked to APOE stabilization and lipid metabolic reprogramming in prostate cancer
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Dioxaborinine-styrylquinoline hybrids as multitarget small-molecule theranostic compounds against Alzheimer's disease
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Structurally diverse indole alkaloids from an endolichenic fungus Aspergillus sp. with antiproliferative activity against non-small cell lung cancer cells
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Targeting autophagy-dependent cell death in cancer therapy: An update on small-molecule compounds
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Functional lysosomal probes from pH sensing and enzyme activation to targeted nanoplatforms
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Recent advances in the discovery of anti-breast cancer agents based on dual-target inhibition strategies
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Structural biology of the dengue virus NS2B–NS3 protease as a target for antiviral drug development
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TAOK inhibitors for cancer therapy: current research progress and future directions
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Computational small molecule drug discovery for multidrug-resistant tuberculosis: emerging targets and recent medicinal chemistry advances
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FABPs-mediated lipid signaling pathways in tumor reprogramming: bidirectional crosstalk with the immune microenvironment
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Selectively and efficiently eliciting a ROS-dependent energy crisis within cancer cells through a mitochondria-targeted catechol-based diphenylhextriene
Cancer is one of the most intractable diseases posing a threat to human health. Chemotherapy is one of the main methods fo...
TBP-TA exhibits potent antibacterial activity against vancomycin-resistant Enterococcus
Antimicrobial resistance (AMR) has emerged as a major global challenge for livestock production [1]. AMR not only exacerba...
Mucoadhesive lignin–liposome nanocarriers of coptisine: A multifunctional strategy against antibiotic-resistant Helicobacter pylori biofilms
Helicobacter pylori (H. pylori) is a widely spread pathogen that infects more than half of the world's population [1]. H. ...
Lometrexol targets MRPL2 to suppress NSCLC via dual regulation of mitochondrial ribosomal activity and nuclear PDCD11/ Ca2+ signaling
Lung cancer, classified into non-small cell lung carcinoma (NSCLC) and small cell lung carcinoma (SCLC), presents a signif...
Reconnecting new tetrahydrobenzothieno-4-pyrimidine amides as potent PIM-1 kinase inhibitors via an integrated ligand, machine learning model and structure based scaffold hopping: In vitro anti-tumor investigations
Cancer development and progression are based on the dysregulated function of the kinases namely tyrosine and serine/threon...
Cascade biocatalysis for pyridoxal 5′-phosphate synthesis with ATP autonomy via polyphosphate kinase
Pyridoxal 5′-phosphate (PLP), the active form of vitamin B6, stands as one of the most versatile enzymatic cofactors in na...
An insight into the anticancer potential of sulfonated styrylquinazolines as multifunctional agents targeting microtubules.
Developing new microtubule-targeting agents is extremely important for cancer treatment. One of the goals is to overcome d...
Comparative study of 47Sc and 177Lu-labeled albumin binder-conjugated FAPI radiopharmaceuticals
The tumor microenvironment (TME) plays a central role in cancer progression and therapeutic resistance. Among its non-mali...
Design, synthesis, and biological evaluation of hydrophobic-tagged poly (ADP-ribose) polymerase 1 (PARP1) degraders
The poly (ADP-ribose) polymerase (PARP) family comprises seventeen DNA-dependent nucleases that are primarily involved in ...
Construction of the chiral 24R-OH squalamine intermediate by an engineered ketoreductase from Rhodococcus sp.
Squalamine, chemically known as 3β-[[3-((4-aminobutyl)amino)propyl]amino]-5α-cholestan-7α,24R-diol-24-sulfonate, was initi...
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