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Circulating biomarkers for diagnosis, prognosis, and treatment response prediction in cancer
Volume 399, 2026, Pages xiii-xviiAuthor links open overlay panelSheila Spada, Lorenzo GalluzziShow moreAccess through your...
Chapter One - Biomarkers for cancer therapy-related cardiovascular toxicity
Cancer and cardiovascular disease are among the leading causes of death worldwide, posing significant threats to human hea...
Chapter Two - Extracellular vesicles as dynamic biomarkers: Monitoring therapeutic responses and drug resistance in cancer
Cancer is still a serious health problem that requires continuous monitoring. New approaches for tracking therapy response...
Chapter Three - Liquid biopsy approaches to capture minimal residual disease and therapy response in patients with early stage cancers
While the goal of treatment for most patients with early-stage cancers is cure, there remains a notable chance for relapse...
Chapter Four - Circulating biomarkers: Facilitating the diagnosis and treatment of cancer and other chronic diseases
Chronic diseases are the leading cause of death worldwide, accounting for approximately 71 % of global death each year, wi...
MRI acute/sub-acute ischemic stroke segmentation with deep learning: A comprehensive review
Brain stroke is a sudden interruption of blood flow in the brain, leading to a lack of oxygen and nutrients to brain tissu...
Advances in protein engineering
Protein engineering (PE) is developing quickly in molecular biology, biochemistry, and computational science (Engqvist &am...
AI application to diagnose mental health disorder: A systematic review
Mental and neurological disorders has been raising a major health concern, impacting more than 3.4 billion people globally...
Recent advances in nanomedicine as drug delivery system
Nanomedicine refers to the application of nanotechnology to diagnose, treat, and prevent various diseases. Nanomedicine fr...
Advances in drug delivery systems
The treatment of human diseases relies on the therapeutic effect achieved by the pharmaceutical compound administered with...
Engineering interleukin-10 for therapeutic applications
Interleukin-10 (IL-10) is an anti-inflammatory cytokine essential for immune homeostasis and the resolution of inflammatio...
IL-23 blockade: A strategy for managing pain-related inflammatory diseases
The International Association for the Study of Pain (IASP) has defined pain as “an unpleasant sensory and emotional experi...
Autophagy in endothelial cells: A gatekeeper of immune cell trafficking and function
The vasculature is a dynamic organ system essential not only for nutrient and oxygen delivery, fluid balance, and haemosta...
Cytokine network in immunosuppression and tumor development in glioblastoma
Glioblastoma (GBM) is the most aggressive and lethal primary brain tumor in adults, with a median survival of approximatel...
The double-edged role of interferon gamma in cancer immunity
Available online 26 February 2026Author links open overlay panelCandelaria Aguilar-García a b c, Alejandra Martínez-Pérez ...
Autophagy meets plant virology: From molecular crosstalk to outstanding challenges
Viruses are among the most devastating microorganisms across all kingdoms of life, posing serious threats to human and ani...
Chapter Four - Cancer and microbiome-targeted therapies
Cancer is the second leading cause of death worldwide and results from mutations occurring during DNA replication, as well...
Chapter Five - Autoimmune diseases and microbiome targeted therapies
Previously regarded solely as a digestive entity, the human gut has been revealed to harbor a rich diversity of microbial ...
Chapter Six - Effect of diet and lifestyle on microbiome composition
Human body is a host to a large number of microorganisms. These microorganisms form a very integrated and complex communit...
Clinical development complexity of TGF-β inhibition: From fibrosis to cancer immunotherapy
Transforming Growth Factor beta (TGF-β) is a cytokine belonging to the growth factors superfamily, that presents three dif...
Dichotomy of IL-27 in tumor immunity
Cytokine activity within the tumor microenvironment plays a crucial role in shaping how innate and adaptive immune cells i...
Targeting TNF-α: An immunotherapeutic approach for alleviating neuropathic pain
The International Association for the Study of Pain (IASP) has defined pain as an “unpleasant sensory and emotional experi...
Cytokine-based immunotherapy in hematolymphoid malignancies
Over the last century, human longevity has increased due to various public health policies, ultimately resulting in higher...
The key role of immunomodulatory cytokines for the development of novel NK cell-based cancer therapies
Natural killer (NK) cells are lymphocytes that belong to the innate immune system known to eliminate transformed cells (ma...
Biomarkers for cancer therapy-related cardiovascular toxicity
Cancer and cardiovascular disease are among the leading causes of death worldwide, posing significant threats to human hea...
Cytokine-driven cancer immune evasion mechanisms
Since the discovery of the first two cytokines, Interleukin (IL)−1α and IL-1β in 1974 by Charles A. Dinarello, (Dinarello,...
Epigenetic insights of microRNAs: Pioneering cancer detection via advanced biosensors
The term “Epigenetics” was first coined in 1942 by embryologist Conrad Waddington, who described it as the “complex develo...
Extracellular vesicles as dynamic biomarkers: Monitoring therapeutic responses and drug resistance in cancer
Cancer is still a serious health problem that requires continuous monitoring. New approaches for tracking therapy response...
The antiviral potential of Vγ9Vδ2 T cells: Therapeutic implications for immunocompromised adult and pediatric hosts
A growing number of pediatric and adult subjects worldwide suffer from impaired immune response to pathogens, due to both ...
Unraveling the role of γδ T cells in inflammatory bowel disease: Development and prevention strategies
Inflammatory bowel diseases (IBD) are autoimmune disorders characterized by considerable heterogeneity in their clinical m...
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