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Advances in research on SATB2 and its role in tumor development
Advances in research on SATB2 and its role in tumor development
SATB2 is an AT-rich DNA-binding protein with a highly restricted expression pattern, primarily found in the brain, digesti...
Filamentation of hCTPS1 with CTP
Filamentation of hCTPS1 with CTP
CTP synthase (CTPS) is a key enzyme in de novo CTP synthesis, playing a critical role in nucleotide metabolism and cellula...
Multi-omics analysis unveiled fibroblast-mediated pathogenesis in male genital lichen sclerosus
Multi-omics analysis unveiled fibroblast-mediated pathogenesis in male genital lichen sclerosus
Male genital lichen sclerosus (LS), a chronic inflammatory dermatological condition, has been recognized for its profound ...
DNA damage response and cell fate decisions across the lifespan: from fetal development to age-related respiratory diseases
DNA damage response and cell fate decisions across the lifespan: from fetal development to age-related respiratory diseases
The integrity and stability of DNA, an essential genetic material, need to be maintained for normal cellular function, gro...
Polygenic risk scores of fasting insulin and insulin-related traits in a Taiwanese Han population
Polygenic risk scores of fasting insulin and insulin-related traits in a Taiwanese Han population
Insulin regulates blood sugar levels and several physiological processes, but many aspects of the relationship between ins...
Single-cell multi-omics analysis reveals candidate therapeutic drugs and key transcription factor specifically for the mesenchymal subtype of glioblastoma
Single-cell multi-omics analysis reveals candidate therapeutic drugs and key transcription factor specifically for the mesenchymal subtype of glioblastoma
The inherent heterogeneity of tumor cells impedes the development of targeted therapies for specific glioblastoma (GBM) su...
Signal regulatory protein α dynamically mediates macrophage polarization facilitated alleviation of ischemic diseases
Signal regulatory protein α dynamically mediates macrophage polarization facilitated alleviation of ischemic diseases
macrophage-targeting therapy of ischemic disease has made progress in clinic trial. However, the role and underlying mecha...
Impact of c-JUN deficiency on thalamus development in mice and human neural models
Impact of c-JUN deficiency on thalamus development in mice and human neural models
c-Jun is a key regulator of gene expression. Through the formation of homo- or heterodimers, c-JUN binds to DNA and regula...
The inactivation of the Niemann Pick C1 cholesterol transporter restricts SARS-CoV-2 entry into host cells by decreasing ACE2 abundance at the plasma membrane
The inactivation of the Niemann Pick C1 cholesterol transporter restricts SARS-CoV-2 entry into host cells by decreasing ACE2 abundance at the plasma membrane
The Niemann Pick C1 (NPC1) protein is an intracellular cholesterol transporter located in the late endosome/lysosome (LE/L...
GSTM2 alleviates heart failure by inhibiting DNA damage in cardiomyocytes
GSTM2 alleviates heart failure by inhibiting DNA damage in cardiomyocytes
Heart failure (HF) seriously threatens human health worldwide. However, the pathological mechanisms underlying HF are stil...
Predictive and prognostic biomarkers of bone metastasis in breast cancer: current status and future directions
Predictive and prognostic biomarkers of bone metastasis in breast cancer: current status and future directions
The most common site of metastasis in breast cancer is the bone, where the balance between osteoclast-mediated bone resorp...
A rapid and stable spontaneous reprogramming system of Spermatogonial stem cells to Pluripotent State
A rapid and stable spontaneous reprogramming system of Spermatogonial stem cells to Pluripotent State
The scarcity of pluripotent stem cells poses a major challenge to the clinical application, given ethical and biosafety co...
Uncoupling p38α nuclear and cytoplasmic functions and identification of two p38α phosphorylation sites on β-catenin: implications for the Wnt signaling pathway in CRC models
Uncoupling p38α nuclear and cytoplasmic functions and identification of two p38α phosphorylation sites on β-catenin: implications for the Wnt signaling pathway in CRC models
Activation of the Wnt pathway has been linked to colorectal cancer (CRC). Previous reports suggest that Wnt3a can activate...
Differential interactome mapping of aggregation prone/prion-like proteins under stress: novel links to stress granule biology
Differential interactome mapping of aggregation prone/prion-like proteins under stress: novel links to stress granule biology
Aberrant stress granules (SGs) are emerging as prime suspects in the nucleation of toxic protein aggregates. Understanding...
Therapeutic uses of oxytocin in stress-related neuropsychiatric disorders
Therapeutic uses of oxytocin in stress-related neuropsychiatric disorders
Oxytocin (OXT), produced and secreted in the paraventricular nucleus and supraoptic nucleus of magnocellular and parvocell...
Single-cell analysis unveils activation of mast cells in colorectal cancer microenvironment
Single-cell analysis unveils activation of mast cells in colorectal cancer microenvironment
The role of mast cells (MCs) in colorectal cancer (CRC) remains unclear, and a comprehensive single-cell study on CRC MCs ...
Captive ERVWE1 triggers impairment of 5-HT neuronal plasticity in the first-episode schizophrenia by post-transcriptional activation of HTR1B in ALKBH5-m6A dependent epigenetic mechanisms
Captive ERVWE1 triggers impairment of 5-HT neuronal plasticity in the first-episode schizophrenia by post-transcriptional activation of HTR1B in ALKBH5-m6A dependent epigenetic mechanisms
Abnormalities in the 5-HT system and synaptic plasticity are hallmark features of schizophrenia. Previous studies suggest ...
Animal models of primary biliary cholangitis: status and challenges
Animal models of primary biliary cholangitis: status and challenges
Primary biliary cholangitis (PBC) is an autoimmune liver disease. The aetiology of PBC remains unclear, and its pathogenes...
Modulation of cell cycle increases CRISPR-mediated homology-directed DNA repair
Modulation of cell cycle increases CRISPR-mediated homology-directed DNA repair
Gene knock‐in (KI) in animal cells via homology‐directed repair (HDR) is an inefficient process, requiring a l...
Oncogenic activation revealed by FGFR2 genetic alterations in intrahepatic cholangiocarcinomas
Oncogenic activation revealed by FGFR2 genetic alterations in intrahepatic cholangiocarcinomas
Except for gene fusions, FGFR2 genetic alterations in intrahepatic cholangiocarcinomas (ICCs) have received limited attent...
Neurokinin-2 receptor negatively modulates substance P responses by forming complex with Neurokinin-1 receptor
Neurokinin-2 receptor negatively modulates substance P responses by forming complex with Neurokinin-1 receptor
Tachykinins and their cognate receptors, neurokinin receptors (NKs) including NK1, NK2, and NK3 play vital roles in regula...
The key cellular senescence related molecule RRM2 regulates prostate cancer progression and resistance to docetaxel treatment
The key cellular senescence related molecule RRM2 regulates prostate cancer progression and resistance to docetaxel treatment
Prostate cancer is a leading cause of cancer-related deaths among men worldwide. Docetaxel chemotherapy has proven effecti...
Coffee as a dietary strategy to prevent SARS-CoV-2 infection
Coffee as a dietary strategy to prevent SARS-CoV-2 infection
To date, most countries lifted the restriction requirement and coexisted with SARS-CoV-2. Thus, dietary behavior for preve...
Clinical biomarkers for Lewy body diseases
Clinical biomarkers for Lewy body diseases
Synucleinopathies are a group of neurodegenerative disorders characterized by pathologic aggregates of neural and glial &#...
METTL3-mediated m6A methylation regulates ovarian cancer progression by recruiting myeloid-derived suppressor cells
METTL3-mediated m6A methylation regulates ovarian cancer progression by recruiting myeloid-derived suppressor cells
Ovarian cancer (OC) typically develops an immunosuppressive microenvironment by funtional changes of host immune cells. Dy...
Causal relationship between gut microbiota and myasthenia gravis: a bidirectional mendelian randomization study
Causal relationship between gut microbiota and myasthenia gravis: a bidirectional mendelian randomization study
Observational studies have demonstrated an association between gut microbiota and myasthenia gravis; however, the causal r...
Musashi-2 in cancer-associated fibroblasts promotes non-small cell lung cancer metastasis through paracrine IL-6-driven epithelial-mesenchymal transition
Musashi-2 in cancer-associated fibroblasts promotes non-small cell lung cancer metastasis through paracrine IL-6-driven epithelial-mesenchymal transition
Lung cancer, the most common cause of cancer-related mortality worldwide, is predominantly associated with advanced/metast...
Correction: Combination chemotherapy of valproic acid (VPA) and gemcitabine regulates STAT3/Bmi1 pathway to differentially potentiate the motility of pancreatic cancer cells
Correction: Combination chemotherapy of valproic acid (VPA) and gemcitabine regulates STAT3/Bmi1 pathway to differentially potentiate the motility of pancreatic cancer cells
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Inhibition of exosome biogenesis affects cell motility in heterogeneous sub-populations of paediatric-type diffuse high-grade gliomas
Inhibition of exosome biogenesis affects cell motility in heterogeneous sub-populations of paediatric-type diffuse high-grade gliomas
Paediatric-type diffuse High-Grade Gliomas (PDHGG) are highly heterogeneous tumours which include distinct cell sub-popula...
Colitis-associated carcinogenesis: crosstalk between tumors, immune cells and gut microbiota
Colitis-associated carcinogenesis: crosstalk between tumors, immune cells and gut microbiota
Colorectal cancer (CRC) is the third most common cancer worldwide. One of the main causes of colorectal cancer is inflamma...
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