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Evolving computational paradigms for noncoding variant pathogenicity prediction
The rapid expansion of whole-genome sequencing (WGS) has highlighted the important contribution of noncoding variants to h...
Chemerin/ChemerinR1 axis and inflammation-related diseases
Inflammation-related diseases, including cardiovascular diseases, immune disorders, and infectious diseases, have high pre...
Machine learning-based prediction of treatment outcomes and quantitative analysis of contributing factors in fertility induction therapy for adolescent male patients with congenital hypogonadotropic hypogonadism
ObjectiveCongenital Hypogonadotropic Hypogonadism (CHH) is a rare disease with an extremely low incidence, and the outcome...
Addressing convergence in the emerging era of structural phylogenetics
Convergent evolution is widespread in biological systems, and any phenotypic trait may experience convergent evolution (Bo...
Circadian regulation in intervertebral disc degeneration: mechanisms and clinical implications
Circadian rhythms are essential for maintaining intervertebral disc (IDD) homeostasis and regulate cellular metabolism, me...
Serum bile acid metabolic profiles in polycystic ovary syndrome: insights from targeted metabolomics and correlation with embryonic parameters
ObjectivePolycystic ovary syndrome (PCOS) is a complex endocrine disorder. In this study, we characterize serum bile acids...
Editorial: Molecular modeling in drug repurposing
We organized this Research Topic to bring together work that uses molecular modeling, broadly defined, to advance drug rep...
Integrative circRNA landscape of intrauterine adhesions: putative ceRNA axes and circRNA-associated splicing usage linked to contractility and immunity
BackgroundIntrauterine adhesions (IUA) are fibrotic scars that impair endometrial regeneration, and compromise fertility. ...
Structural and ensemble-based mechanistic insights into cytoplasmic dynein-1
Cytoplasmic dynein-1 is a multi-subunit motor that transports diverse cargoes toward microtubule minus-ends, playing cruci...
Diagnostic and short-term prognosis value of serum ox-LDL/LOX-1 and GDF-15 in elderly patients with acute coronary syndrome
BackgroundIn the diagnosis and short-term prognosis of elderly patients with acute coronary syndrome (ACS), there has been...
Association and predictive value of systemic immune–inflammation index and body mass index in cervical ossification of the posterior longitudinal ligament
IntroductionCervical ossification of the posterior longitudinal ligament (C-OPLL) is a common cause of cervical myelopathy...
Tumor-directed evolution of VSVΔ51M produces novel viruses with enhanced antitumor efficacy
Oncolytic virotherapy has gained enormous attention and is undergoing extensive research, specifically, the Vesicular Stom...
Comparative phytochemical, antioxidant, and hemostatic studies of leaf and stem extracts of Rhazya stricta Decne. in human plasma and human peripheral blood mononuclear cells in vitro
IntroductionRhazya stricta Decne. is considered an important medicinal plant that is rich in secondary metabolites contain...
Editorial: Precision nutrition for lifestyle, health and disease
Genetic, environmental and lifestyle factors dynamically interact and shape individual health over time. Modelling these i...
Using native human sera to assess the suitability of external quality assessment materials based on testosterone, progesterone, and 17β-estradiol measurements
IntroductionThe commonly processed nature of the control materials used in the external quality assessment (EQA) of medica...
Endurance training increases tmTNF-α and IL-6 levels in several vital organs in rats: relationship with hypoxia markers
BackgroundAlthough endurance training is known to induce systemic adaptations involving inflammatory and hypoxia-related s...
Calcium release deficiency syndrome: an emerging ryanodinopathy
The cardiac ryanodine receptor (RyR2) is a critical calcium release channel essential for normal cardiac contraction. Dysr...
Phenylalanine–tyrosine–catecholamine axis disorders: pathways, molecular diagnosis, therapeutics, and emerging translational monitoring technologies
Disorders of the phenylalanine–tyrosine–catecholamine axis are a clinically relevant group of neurometabolic conditions in...
Evaluation of the effect of a single dose of morroniside on rat liver subjected to ischemia and reperfusion
IntroductionHepatic ischemia-reperfusion (IR) injury remains a major clinical problem during liver surgery and transplanta...
Immune cells in thyroid adenoma and carcinoma: uncovering a hidden value of assessing tumor-host interplay and its potential application in thyroid cytopathology
IntroductionThyroid cancer (TC) is one of the most common endocrine malignancies (Siegel et al., 2021). The incidence of T...
Opportunities, challenges, and difficulties in NMR-based metabolomics applied to neovascular age-related macular degeneration (nAMD) patient follow-up
1 IntroductionAge-related macular degeneration (AMD) is the leading cause of vision loss among the aging population in Wes...
Decoding oral cancer: insights from miRNA expression profiles and their regulatory targets
1 IntroductionOral cancer (OC) is a malignant disease that poses significant threat to human health, ranking as the sixth ...
Aging, cancer, and autophagy: connections and therapeutic perspectives
1 IntroductionAging is a progressive, multifaceted process characterized by evolving cellular and molecular deterioration ...
Individual-network based predictions of microbial interaction signatures for response to biological therapies in IBD patients
IntroductionThe advent of high-throughput sequencing in clinical research has enabled the molecular profiling of individua...
Cellular and immune landscape of chronic liver diseases: insights from immunophenotyping
1 IntroductionChronic liver disease (CLD) represents a significant challenge to global health, characterized by persistent...
Editorial: Exosomal biomarkers: roles in diagnostics and therapeutics, Volume II
towards cost-effective diagnostics, non-invasive biopsy, novel therapeutic strategies and solutions toward infertility tre...
Sotorasib resistance triggers epithelial-mesenchymal transition and activates AKT and P38-mediated signaling
Sotorasib resistance triggers epithelial-mesenchymal transition and activates AKT and P38-mediated signaling
1 IntroductionKRAS (Kirsten rat sarcoma two viral oncogene homolog) stands out as one of the most prevalent oncogenes acro...
Epigenetic regulation in coronary artery disease: from mechanisms to emerging therapies
1 IntroductionCardiovascular diseases have been the leading cause of death worldwide, with coronary artery disease (CAD) b...
Potential biomarkers and immune infiltration linking endometriosis with recurrent pregnancy loss based on bioinformatics and machine learning
1 IntroductionEndometriosis (EMs) is an estrogen-dependent chronic gynecological inflammatory disease. Its most typical cl...
Dual targeting carbonic anhydrase inhibitors as promising therapeutic approach: a structural overview
1 IntroductionHuman carbonic anhydrases (hCAs) are zinc-containing metalloenzymes that catalyze the reversible hydration r...
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