Patel M, Goel AD, Saini L et al (2025) Prevalence of pediatric and adolescent epilepsy in India: a systematic review and meta-analysis. Seizure: Eur J Epilepsy 127:36–43. https://doi.org/10.1016/j.seizure.2025.02.012

Article  Google Scholar 

Egesa IJ, Newton CRJC, Kariuki SM (2022) Evaluation of the International League Against Epilepsy 1981, 1989, and 2017 classifications of seizure semiology and etiology in a population-based cohort of children and adults with epilepsy. Epilepsia Open 7:98–109. https://doi.org/10.1002/epi4.12562

Article  PubMed  Google Scholar 

Safeer VSM, Sahu JK, Madaan P et al (2024) Estimating the active and lifetime prevalence and incidence of epilepsy in Asian Countries: a systematic review and meta-analysis. Epilepsy Behav. https://doi.org/10.1016/j.yebeh.2024.109739

Article  Google Scholar 

Gammoh O, Al-Smadi A, Mansour M et al (2024) The relationship between psychiatric symptoms and the use of levetiracetam in people with epilepsy. Int J Psychiatry Med 59:360–372. https://doi.org/10.1177/00912174231206056

Article  PubMed  Google Scholar 

Amudhan S, Gururaj G, Satishchandra P (2015) Epilepsy in India I: epidemiology and public health. Ann Indian Acad Neurol 18:263. https://doi.org/10.4103/0972-2327.160093

Article  PubMed  PubMed Central  Google Scholar 

Franco V, Perucca E (2015) The pharmacogenomics of epilepsy. Expert Rev Neurother 15:1161–1170. https://doi.org/10.1586/14737175.2015.1083424

Article  CAS  PubMed  Google Scholar 

Dhiman V (2017) Molecular genetics of epilepsy: a clinician’s perspective. Ann Indian Acad Neurol 20:96–102. https://doi.org/10.4103/aian.AIAN_447_16

Article  PubMed  PubMed Central  Google Scholar 

Kam H, Jeong H (2020) Pharmacogenomic biomarkers and their applications in psychiatry. Genes 11:1–22. https://doi.org/10.3390/genes11121445

Article  CAS  Google Scholar 

Luo H, Ding X, Zhang J, Xiao N (2025) Comparative effectiveness of non-pharmacological interventions on anxiety, depression, and quality of life in patients with epilepsy: a systematic review and network meta-analysis. Front Psychiatry 16:1624276. https://doi.org/10.3389/fpsyt.2025.1624276

Article  PubMed  PubMed Central  Google Scholar 

Lei AA, Phang VWX, Lee YZ et al (2025) Chronic stress-associated depressive disorders: the impact of HPA axis dysregulation and neuroinflammation on the Hippocampus—a mini review. Int J Mol Sci 26:2940. https://doi.org/10.3390/ijms26072940

Article  CAS  PubMed  PubMed Central  Google Scholar 

Prasad DKV, Shaheen U, Satyanarayana U et al (2014) Association of serum trace elements and minerals with genetic generalized epilepsy and idiopathic intractable epilepsy. Neurochem Res 39:2370–2376. https://doi.org/10.1007/s11064-014-1439-3

Article  CAS  PubMed  Google Scholar 

Liu W, Xu J, Zhang L et al (2023) Research progress on correlations between trace element levels and epilepsy. Front Cell Dev Biol. https://doi.org/10.3389/fcell.2023.1167626

Article  PubMed  PubMed Central  Google Scholar 

Azargoonjahromi A (2024) A systematic review of the association between zinc and anxiety. Nutr Rev 82:612–621. https://doi.org/10.1093/nutrit/nuad076

Article  PubMed  Google Scholar 

Jomová K, Al-Omar SY, Valko R et al (2025) The role of redox-active iron, copper, manganese, and redox-inactive zinc in toxicity, oxidative stress, and human diseases. EXCLI J 24:880–954. https://doi.org/10.17179/excli2025-8449

Article  PubMed  PubMed Central  Google Scholar 

Gao F, Yang Z, Li J (2025) The miR-34a-5p promotes Hippocampal neuronal ferroptosis in epilepsy by regulating SIRT1. Neurochem Res. https://doi.org/10.1007/s11064-025-04378-y

Article  PubMed  Google Scholar 

Di Lisi A, Valle AD, Menchetti M et al (2025) The potential benefits of chromium and selenium supplementation across psychiatric disorders and symptoms. J Clin Psychopharmacol 45:376–387. https://doi.org/10.1097/JCP.0000000000002014

Article  PubMed  PubMed Central  Google Scholar 

Akyol O (1999) Serum and hair trace element levels in patients with epilepsy and healthy subjects: does the antiepileptic therapy affect the element concentrations of hair? Eur J Neurol 6:705–709. https://doi.org/10.1046/j.1468-1331.1999.t01-1-660705.x

Article  PubMed  Google Scholar 

Stanojević M, Djuricic N, Parezanovic M et al (2025) The impact of chronic magnesium deficiency on excitable tissues—translational aspects. Biol Trace Elem Res 203:707–728. https://doi.org/10.1007/s12011-024-04216-2

Article  CAS  PubMed  Google Scholar 

Rothan HA, Amini E, Faraj FL et al (2017) NMDA receptor antagonism with novel indolyl, 2-(1,1-dimethyl-1,3-dihydro-benzo[e]indol-2-ylidene)-malonaldehyde, reduces seizures duration in a rat model of epilepsy. Sci Rep. https://doi.org/10.1038/srep45540

Article  PubMed  PubMed Central  Google Scholar 

Liu L, Liang J, Liu Q et al (2019) Elevated plasma homocysteine levels in anti-N-methyl-D-aspartate receptor encephalitis. Front Neurol 10:464. https://doi.org/10.3389/fneur.2019.00464

Article  PubMed  PubMed Central  Google Scholar 

Madireddy S, Madireddy S (2023) Therapeutic strategies to ameliorate neuronal damage in epilepsy by regulating oxidative stress, mitochondrial dysfunction, and neuroinflammation. Brain Sci. https://doi.org/10.3390/brainsci13050784

Article  PubMed  PubMed Central  Google Scholar 

Zhao Y, Lu C, Wang H et al (2020) Identification of hsa-miR-1275 as a novel biomarker targeting MECP2 for human epilepsy of unknown etiology. Mol Ther Methods Clin Dev 19:398–410. https://doi.org/10.1016/j.omtm.2020.10.005

Article  CAS  PubMed  PubMed Central  Google Scholar 

Simani L, Sadeghi M, Ryan F et al (2020) Elevated blood-based brain biomarker levels in patients with epileptic seizures: a systematic review and meta-analysis. ACS Chem Neurosci 11:4048–4059. https://doi.org/10.1021/acschemneuro.0c00492

Article  CAS  PubMed  Google Scholar 

González-Rivera JA, Pagán-Torres OM, Pérez-Torres EM (2020) Depression, anxiety and stress scales (DASS-21): construct validity problem in Hispanics. EJIHPE 10:375–389. https://doi.org/10.3390/ejihpe10010028

Article  PubMed  PubMed Central  Google Scholar 

Farnia V, Afshari D, Abdoli N et al (2021) The effect of substance abuse on depression, anxiety, and stress (DASS-21) in epileptic patients. Clin Epidemiol Glob Health 9:128–131. https://doi.org/10.1016/j.cegh.2020.08.001

Article  CAS  Google Scholar 

Azmoodeh S, Soleimani E, Issazadegan A (2021) The effects of transcranial direct current stimulation on depression, anxiety, and stress in patients with epilepsy: a randomized clinical trial. Iran J Med Sci. https://doi.org/10.30476/ijms.2020.83233.1215

Article  PubMed  PubMed Central  Google Scholar 

Xue J, Li X, Zhao Y et al (2025) Global, regional, and national burden of idiopathic epilepsy in older adults, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021. BMC Med. https://doi.org/10.1186/s12916-025-04268-8

Article  PubMed  PubMed Central  Google Scholar 

Wei Y, Li H, Li Y et al (2024) Advances of curcumin in nervous system diseases: the effect of regulating oxidative stress and clinical studies. Front Pharmacol. https://doi.org/10.3389/fphar.2024.1496661

Article  PubMed  PubMed Central  Google Scholar 

Mo Y-Q, Zhong J-Y, Teng M-J et al (2025) Advances in research on neurotoxicity and mechanisms of manganese, iron, and copper exposure, alone or in combination. J Appl Toxicol 45:1968–1983. https://doi.org/10.1002/jat.4833

Article  CAS  PubMed