Bergengren O, Pekala KR, Matsoukas K, Fainberg J, Mungovan SF, Bratt O, Bray F, Brawley O, Luckenbaugh AN, Mucci L, Morgan TM, Carlsson SV (2023) 2022 update on prostate cancer epidemiology and risk factors-a systematic review. Eur Urol 84(2):191–206

PubMed  PubMed Central  Google Scholar 

Trujillo B, Wu AJ, Wetterskog D, Attard G (2022) Blood-based liquid biopsies for prostate cancer: clinical opportunities and challenges. Br J Cancer 127(8):1394–1402

CAS  PubMed  PubMed Central  Google Scholar 

Rajwa P, Pradere B, Mori K, Ploussard G, Leapman MS, Shariat SF (2021) Association of negative followup biopsy and reclassification during active surveillance of prostate cancer: a systematic review and meta-analysis. J Urol 205(6):1559–1568

PubMed  Google Scholar 

Bologna E, Ditonno F, Licari LC, Franco A, Manfredi C, Mossack S, Pandolfo SD, De Nunzio C, Simone G, Leonardo C, Franco G (2024) Tissue-based genomic testing in prostate cancer: 10-year analysis of national trends on the use of prolaris, decipher, promark, and oncotype DX. Clinics Pract 14(2):508–520

Google Scholar 

Parikh AR, Leshchiner I, Elagina L, Goyal L, Levovitz C, Siravegna G, Livitz D, Rhrissorrakrai K, Martin EE, Van Seventer EE, Hanna M, Slowik K, Utro F, Pinto CJ, Wong A, Danysh BP, de la Cruz FF, Fetter IJ, Nadres B, Shahzade HA, Allen JN, Blaszkowsky LS, Clark JW, Giantonio B, Murphy JE, Nipp RD, Roeland E, Ryan DP, Weekes CD, Kwak EL, Faris JE, Wo JY, Aguet F, Dey-Guha I, Hazar-Rethinam M, Dias-Santagata D, Ting DT, Zhu AX, Hong TS, Golub TR, Iafrate AJ, Adalsteinsson VA, Bardelli A, Parida L, Juric D, Getz G, Corcoran RB (2019) Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers. Nature Med. https://doi.org/10.1038/s41591-019-0561-9

Article  PubMed  Google Scholar 

Ma LW, Guo HL, Zhao YX, Liu ZB, Wang CR, Bu JH, Sun T, Wei JW (2024) Liquid biopsy in cancer: current status, challenges and future prospects. Signal Transduct Target Ther. https://doi.org/10.1038/s41392-024-02021-w

Article  PubMed  PubMed Central  Google Scholar 

Welsh JB, Sapinoso LM, Kern SG, Brown DA, Liu T, Bauskin AR, Ward RL, Hawkins NJ, Quinn DI, Russell PJ, Sutherland RL, Breit SN, Moskaluk CA, Frierson HF, Hampton GM (2003) Large-scale delineation of secreted protein biomarkers overexpressed in cancer tissue and serum. Proc Natl Acad Sci USA 100(6):3410–3415

CAS  PubMed  PubMed Central  Google Scholar 

Barlowe CK, Miller EA (2013) Secretory Protein Biogenesis and Traffic in the Early Secretory Pathway. Genetics 193(2):383–410

CAS  PubMed  PubMed Central  Google Scholar 

Landegren U, Hammond M (2021) Cancer diagnostics based on plasma protein biomarkers: hard times but great expectations. Mol Oncol 15(6):1715–1726

PubMed  Google Scholar 

Li JF, Li JJ, Hao HF, Lu FL, Wang J, Ma ML, Jia B, Zhuo ML, Wang JJ, Chi YJ, Zhai XY, Wang YY, Wu MN, An TT, Zhao J, Yang F, Wang ZP (2023) Secreted proteins MDK, WFDC2, and CXCL14 as candidate biomarkers for early diagnosis of lung adenocarcinoma. Cancer. https://doi.org/10.1186/s12885-023-10523-z

Article  PubMed  PubMed Central  Google Scholar 

Ge RB, Wang ZW, Cheng L (2022) Tumor microenvironment heterogeneity an important mediator of prostate cancer progression and therapeutic resistance. Precis Oncol. https://doi.org/10.1038/s41698-022-00272-w

Article  Google Scholar 

El-Kenawi A, Viqueira WD, Liu M, Awasthi S, Dhillon J, Yamoah K, Yu XQ, Koomen J, Gatenby R, Ruffell B (2021) Macrophage tumor cell metabolic interactions induce therapeutic resistance in prostate cancer. Cancer Res. https://doi.org/10.1158/0008-5472.CAN-20-4028

Article  PubMed  PubMed Central  Google Scholar 

Ruffell B, Coussens LM (2015) Macrophages and therapeutic resistance in cancer. Cancer Cell 27(4):462–472

CAS  PubMed  PubMed Central  Google Scholar 

Xu N, Dong RN, Lin TT, Lin T, Lin YZ, Chen SH, Zhu JM, Ke ZB, Huang F, Chen YH, Xue XY (2021) Development and validation of novel biomarkers related to m2 macrophages infiltration by weighted gene co-expression network analysis in prostate cancer. Front Oncol. https://doi.org/10.3389/fonc.2021.634075

Article  PubMed  PubMed Central  Google Scholar 

Gu QN, Qi AN, Wang N, Zhou ZX, Zhou XH (2024) Macrophage dynamics in prostate cancer: molecular to therapeutic insights. Biomed Pharma. https://doi.org/10.1016/j.biopha.2024.117002

Article  Google Scholar 

Liu W, Zhou XW, Liu SJ, Hu KH, Wang C, He QY, Li MT (2009) Calpain-truncated CRMP-3 and-4 contribute to potassium deprivation-induced apoptosis of cerebellar granule neurons. Proteomics 9(14):3712–3728

CAS  PubMed  Google Scholar 

Chun JN, Cho M, Park S, So I, Jeon JH (2020) The conflicting role of E2F1 in prostate cancer: A matter of cell context or interpretational flexibility. Biochimica Et Biophysica Acta-Reviews on Cancer. https://doi.org/10.1016/j.bbcan.2019.188336

Article  PubMed  Google Scholar 

Minegishi Y, Hiroshima Y, Yazawa K, Sato S, Yabushita Y, Homma Y, Matsuyama R, Kato I, Goshima Y, Endo I (2022) CRMP4 Up-regulates M2 macrophages and myeloid-derived suppressor cells to promote pancreatic cancer in mice. Anticancer Res 42(2):791–799

CAS  PubMed  Google Scholar 

Chomczynski P, Sacchi N (2006) The single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction: twenty-something years on. Nat Protoc 1(2):581–585

CAS  PubMed  Google Scholar 

Li LF, Xu XJ, Zhao Y, Liu ZB, Shen ZZ, Jin WR, Shao ZM (2009) Integrated gene expression profile predicts prognosis of breast cancer patients. Breast Cancer Res Treat 113(2):231–237

CAS  PubMed  Google Scholar 

Uhlen M, Oksvold P, Fagerberg L, Lundberg E, Jonasson K, Forsberg M, Zwahlen M, Kampf C, Wester K, Hober S, Wernerus H, Björling L, Ponten F (2010) Towards a knowledge-based Human Protein Atlas. Nat Biotechnol 28(12):1248–1250

CAS  PubMed  Google Scholar 

Newman AM, Liu CL, Green MR, Gentles AJ, Feng W, Xu Y, Hoang CD, Diehn M, Alizadeh AA (2015) Robust enumeration of cell subsets from tissue expression profiles. Nat Methods 12(5):453–457

CAS  PubMed  PubMed Central  Google Scholar 

Cheng SY, Li L, Yeh YS, Shi YL, Franco O, Corey E, Yu XP (2024) Unveiling novel double-negative prostate cancer subtypes through single-cell RNA sequencing analysis. Precis Oncol. https://doi.org/10.1101/2023.08.11.553009

Article  Google Scholar 

Du SA, Zhu C, Ren XL, Chen X, Cui X, Guan S (2023) Regulation of secretory pathway kinase or kinase-like proteins in human cancers. Front Immunol. https://doi.org/10.3389/fimmu.2023.942849

Article  PubMed  PubMed Central  Google Scholar 

Atala A (2016) Mesenchymal stem cells are recruited and activated into carcinoma-associated fibroblasts by prostate cancer microenvironment-derived TGF-β1. J Urol 196(6):1817–1817

PubMed  Google Scholar 

Gough NR, Xiang XY, Mishra L (2021) TGF-β signaling in liver, pancreas, and gastrointestinal diseases and cancer. Gastroenterology. https://doi.org/10.1053/j.gastro.2021.04.064

Article  PubMed  Google Scholar 

Chan MKK, Chung JYF, Tang PCT, Chan ASW, Ho JYY, Lin TPT, Chen JY, Leung KT, To KF, Lan HY, Tang PMK (2022) TGF-β signaling networks in the tumor microenvironment. Cancer Lett. https://doi.org/10.3390/ijms22147575

Article  PubMed  PubMed Central  Google Scholar 

Chou YT, Wang H, Chen Y, Danielpour D, Yang YC (2006) Cited2 modulates TGF-β-mediated upregulation of MMP9. Oncogene 25(40):5547–5560

CAS  PubMed  Google Scholar 

Mamoune A, Luo JH, Lauffenburger DA, Wells A (2003) Calpain-2 as a target for limiting prostate cancer invasion. Can Res 63(15):4632–4640

CAS  Google Scholar 

Gao X, Mao YH, Xiao CT, Li K, Liu W, Li LY, Pang J (2018) Calpain-2 triggers prostate cancer metastasis via enhancing CRMP4 promoter methylation through NF-B/DNMT1 signaling pathway. Prostate 78(9):682–690

CAS  PubMed  Google Scholar 

Adamo P, Ladomery MR (2016) The oncogene ERG: a key factor in prostate cancer. Oncogene 35(4):403–414

CAS  PubMed  Google Scholar 

Liu RSC, Olkhov-Mitsel E, Jeyapala R, Zhao F, Commisso K, Klotz L, Loblaw A, Liu SK, Vesprini D, Fleshner NE, Bapat B (2018) Assessment of serum microRNA biomarkers to predict reclassification of prostate cancer in patients on active surveillance. J Urol 199(6):1476–1482

Google Scholar 

Urabe F, Matsuzaki J, Yamamoto Y, Kimura T, Hara T, Ichikawa M, Takizawa S, Aoki Y, Niida S, Sakamoto H, Kato K, Egawa S, Fujimoto H, Ochiya T (2019) Large-scale circulating microRNA profiling for the liquid biopsy of prostate cancer. Clin Cancer Res 25(10):3016–3025

CAS  PubMed  Google Scholar 

Halabi S, Guo S, Park JJ, Nanus DM, George DJ, Antonarakis ES, Danila DC, Szmulewitz RZ, McDonnell DP, Norris JD, Lu C, Luo J, Armstrong AJ (2024) The impact of circulating tumor cell HOXB13 RNA detection in men with metastatic castration-resistant prostate cancer (mCRPC) treated with abir