Hirschsprung disease and associated urological morbidities: institutional experience and systematic review

Sergi CM, Caluseriu O, McColl H, Eisenstat DD (2016) Hirschsprung’s disease: clinical dysmorphology, genes, micro-RNAs, and future perspectives. Pediatr Res 81:177–191. https://doi.org/10.1038/pr.2016.202

Article  PubMed  Google Scholar 

Pham HD, Dao DD, Tran QA, Nguyen NT, Ly DB, Bui HD, Nguyen LT, Nguyen QT (2025) Single-incision laparoscopic endorectal pull-through for hirschsprung disease: a prospective institutional study and systematic review with meta-analysis. Surg Endosc. https://doi.org/10.1007/s00464-025-12114-4

Article  PubMed  PubMed Central  Google Scholar 

Hofmann AD, Duess JW, Puri P (2014) Congenital anomalies of the kidney and urinary tract (CAKUT) associated with hirschsprung’s disease: a systematic review. Pediatr Surg Int 30:757–761. https://doi.org/10.1007/s00383-014-3529-3

Article  PubMed  Google Scholar 

Prato AP, Arnoldi R, Falconi I et al (2021) Congenital anomalies of the kidney and urinary tract in a cohort of 280 consecutive patients with Hirschsprung disease. Pediatr Nephrol 36:3151–3158. https://doi.org/10.1007/s00467-021-05061-4

Article  Google Scholar 

Machens A, Lorenz K, Dralle H (2021) Kidney malformations and Hirschsprung’s disease in carriers of cysteine mutations in exon 10 of the RET proto-oncogene. Endocrine 73:217–222. https://doi.org/10.1007/s12020-021-02686-1

Article  CAS  PubMed  Google Scholar 

Gunnarsdóttir A, Sandblom G, Arnbjörnsson E, Larsson LT (2010) Quality of life in adults operated on for hirschsprung disease in childhood. J Pediatr Gastroenterol Nutr 51:160–166. https://doi.org/10.1097/MPG.0b013e3181cac1b6

Article  PubMed  Google Scholar 

Mehmood M, Akhtar J, Zamir N (2024) Congenital anomalies of the kidney and urinary tract in patients with hirschsprung disease. J Coll Physicians Surg Pak 34:1334–1337. https://doi.org/10.29271/jcpsp.2024.11.1334

Article  PubMed  Google Scholar 

Davis TK, Hoshi M, Jain S (2014) To bud or not to bud: the RET perspective in CAKUT. Pediatr Nephrol 29:597–608. https://doi.org/10.1007/s00467-013-2606-5

Article  PubMed  PubMed Central  Google Scholar 

Neuvonen M, Kyrklund K, Taskinen S, Koivusalo A, Rintala RJ, Pakarinen MP (2017) Lower urinary tract symptoms and sexual functions after endorectal pull-through for hirschsprung disease: controlled long-term outcomes. J Pediatr Surg 52:1296–1301. https://doi.org/10.1016/j.jpedsurg.2017.02.013

Article  PubMed  Google Scholar 

Granéli C, Sima HM, Börjesson A, Hagelsteen K, Arnbjörnsson E, Stenström P (2019) Urinary tract anomalies and urinary tract dysfunction in children with hirschsprung disease—is follow-up indicated? J Pediatr Surg 54:2012–2016. https://doi.org/10.1016/j.jpedsurg.2018.12.006

Article  PubMed  Google Scholar 

Versteegh HP, Navroop SJ, de Blaauw I, Stanton MP (2016) Urological and sexual outcome in patients with Hirschsprung disease: a systematic review (2016). J Pediatr Urol 12:352–360. https://doi.org/10.1016/j.jpurol.2016.07.019

Article  PubMed  Google Scholar 

von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP, STROBE Initiative (2007) The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. BMJ 335:806–808. https://doi.org/10.1136/bmj.39335.541782.AD

Article  Google Scholar 

Farhat W, Bägli DJ, Capolicchio G, O’Reilly S, Merguerian PA, Khoury A, McLorrie GA (2000) The dysfunctional voiding scoring system: quantitative standardization of dysfunctional voiding symptoms in children. J Urol 164:1011–1015. https://doi.org/10.1016/S0022-5347(05)67239-4

Article  CAS  PubMed  Google Scholar 

Jiang R, Kelly MS, Routh JC (2018) Assessment of pediatric bowel and bladder dysfunction: a critical appraisal of the literature. J Pediatr Urol 14:494–501. https://doi.org/10.1016/j.jpurol.2018.08.010

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wells GA, Shea B, O’Connell D, Peterson J, Welch V, Losos M, Tugwell P (2021) The Newcastle–Ottawa scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Ottawa Hospital Research Institute. http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp

Shea BJ, Grimshaw JM, Wells GA, Boers M, Andersson N, Hamel C et al (2007) Development of AMSTAR: a measurement tool to assess the methodological quality of systematic reviews. BMC Med Res Methodol 7:10. https://doi.org/10.1186/1471-2288-7-10

Article  PubMed  PubMed Central  Google Scholar 

Nguyen QT, Dao DD, Chan QA, Nguyen NT, Ly DB, Nguyen LT, Pham HD (2025) Single-incision laparoscopic endorectal pull-through for Hirschsprung’s disease in neonates: A prospective study on medium-term outcomes. J Pediatr Surg. https://doi.org/10.1016/j.jpedsurg.2025.162553

Article  PubMed  Google Scholar 

Chang JW, Liu CS, Tsai HL (2022) Vesicoureteral reflux in children with urinary tract infections in the inpatient setting in Taiwan. Clin Epidemiol 14:299–307. https://doi.org/10.2147/CLEP.S346645

Article  PubMed  PubMed Central  Google Scholar 

Boemers TM, Bax NMA, van Gool JD (2001) The effect of rectosigmoidectomy and Duhamel-type pull-through procedure on lower urinary tract function in children with Hirschsprung’s disease. J Pediatr Surg 36:453–456. https://doi.org/10.1053/jpsu.2001.21615

Article  CAS  PubMed  Google Scholar 

Peng C, Tan SS, Pang W, Wang Z, Wu D, Wang K et al (2021) Rectourethral and rectovesical fistula as serious and rare complications after Hirschsprung disease operation: experience in seven patients. J Pediatr Surg 56:263–268. https://doi.org/10.1016/j.jpedsurg.2020.06.042

Article  PubMed  Google Scholar 

Zahi S, Mahir L, Lmidmani F, El Fatimi A (2017) Assessment of lower urinary tract function in children before and after transanal endorectal pull through for Hirschsprung’s disease. Ann Pediatr Surg 13:217–219. https://doi.org/10.1097/01.XPS.0000516073.83659.56

Article  Google Scholar 

Hoel AT, Karlsen RA, Fosby MV, Bjørnland K (2023) Sexual function and lower urinary tract symptoms after minimally invasive endorectal pull-through in adolescent males with Hirschsprung disease. J Pediatr Surg 58:490–495. https://doi.org/10.1016/j.jpedsurg.2022.09.017

Article  PubMed  Google Scholar 

Dingemans AJM, Reck-Burneo CA, Fuchs M, Sanchez AV, Lane VA, Hoover E et al (2019) Urinary outcomes in patients with Down’s syndrome and Hirschsprung’s disease. Eur J Pediatr Surg 29:378–383. https://doi.org/10.1055/s-0038-1660509

Article  PubMed  Google Scholar 

Mills JLA, Konkin DE, Milner R, Penner JG, Langer M, Webber EM (2008) Long-term bowel function and quality of life in children with Hirschsprung’s disease. J Pediatr Surg 43:899–905. https://doi.org/10.1016/j.jpedsurg.2007.12.038

Article  PubMed  Google Scholar 

Ateş O, Hakgüder G, Kart Y, Olguner M, Akgür FM (2007) The effect of dilated ganglionic segment on anorectal and urinary functions during 1-stage Transanal endorectal pull through for Hirschsprung’s disease. J Pediatr Surg 42:1271–1275. https://doi.org/10.1016/j.jpedsurg.2007.02.020

Article  PubMed  Google Scholar 

Salvi PS, Cowles RA (2023) The burden of congenital heart disease and urogenital lesions in a National cohort of Hirschsprung patients. J Pediatr Surg 58:2165–2170. https://doi.org/10.1016/j.jpedsurg.2023.06.014

Article  PubMed  Google Scholar 

Eelen J, Miserez M, Mekahli D, Hoffman I (2020) Hirschprung disease and congenital anomalies of the kidney and urinary tract (CAKUT): a genetic disorder or just a coincidence? Belg J Paediatr 22:126–129

Google Scholar 

Jakobson-Setton A, Weissmann‐Brenner A, Achiron R, Kuint J, Gindes L (2015) Retrospective analysis of prenatal ultrasound of children with Hirschsprung disease. Prenat Diagn 35:699–702. https://doi.org/10.1002/pd.4595

Article  CAS  PubMed  Google Scholar 

Rassouli R, Holscheneider AM, Bolkenius M, Menardi G, Becker MR, Schaarschmidt K et al (2003) Long-term results of rehbein’s procedure: a retrospective study in German speaking countries. Eur J Pediatr Surg 13:187–194. https://doi.org/10.1055/s-2003-41258

Article  CAS  PubMed  Google Scholar 

Davidson JR, Kyrklund K, Eaton S, Pakarinen MP, Thompson DS, Cross K et al (2021) Long-term surgical and patient-reported outcomes of Hirschsprung disease. J Pediatr Surg 56:1502–1511. https://doi.org/10.1016/j.jpedsurg.2021.01.043

Article  PubMed  Google Scholar 

Catto-Smith AG, Trajanovska M, Taylor RG (2007) Long‐term continence after surgery for Hirschsprung’s disease. J Gastroenterol Hepatol 22:2273–2282. https://doi.org/10.1111/j.1440-1746.2006.04750.x

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