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Ivonescimab Plus Chemotherapy versus Bevacizumab Plus Chemotherapy in EGFR-Mutant Lung Adenocarcinoma After EGFR-TKI Failure: A Two-Center Retrospective Real-World Propensity Score-Matched Study
Ivonescimab Plus Chemotherapy versus Bevacizumab Plus Chemotherapy in EGFR-Mutant Lung Adenocarcinoma After EGFR-TKI Failure: A Two-Center Retrospective Real-World Propensity Score-Matched Study
Compared with bevacizumab plus chemotherapy, ivonescimab plus chemotherapy prolongs survival with manageable safety in thi...
First-in-Human Phase I Trial of HRS-2129, a Selective Nav1.8 Inhibitor: Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics in Healthy Subjects
First-in-Human Phase I Trial of HRS-2129, a Selective Nav1.8 Inhibitor: Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics in Healthy Subjects
Within the evaluated dose range, HRS-2129 demonstrated a favorable safety profile, predictable PK with low accumulation, a...
Assessment: An Unresolved Intercurrent Event in a Randomized Trial of Ciprofol versus Propofol [Response to Letter]
Assessment: An Unresolved Intercurrent Event in a Randomized Trial of Ciprofol versus Propofol [Response to Letter]
Response to Letter in regards to Assessment: An Unresolved Intercurrent Event in a Randomized Trial of Ciprofol versus Pro...
Ultrasound-Guided Infraspinatus-Teres Minor Interfascial Block versus Interscalene Brachial Plexus Block for Analgesia After Arthroscopic Shoulder Surgery: A Randomized Non-Inferiority Clinical Trial
Ultrasound-Guided Infraspinatus-Teres Minor Interfascial Block versus Interscalene Brachial Plexus Block for Analgesia After Arthroscopic Shoulder Surgery: A Randomized Non-Inferiority Clinical Trial
This trial compares ultrasound-guided ITMB vs ISB for postoperative analgesia, respiratory safety, and adverse events in a...
Assessment of the Cytotoxic and Apoptotic Impacts of Bimetallic Zinc Iron Oxide Nanoparticles on HuH-7 Cell Line
Assessment of the Cytotoxic and Apoptotic Impacts of Bimetallic Zinc Iron Oxide Nanoparticles on HuH-7 Cell Line
ZnFe2O4NPs as a cytotoxic agent via oxidative stress could be useful in various cancer treatments
Interpreting Perineural Esketamine for Analgesia After Total Knee Arthroplasty: Methodological and Reporting Considerations [Response to Letter]
Interpreting Perineural Esketamine for Analgesia After Total Knee Arthroplasty: Methodological and Reporting Considerations [Response to Letter]
Response to Letter in regards to Interpreting Perineural Esketamine for Analgesia After Total Knee Arthroplasty: Methodolo...
Letter to the Editor Regarding "Effects of Desflurane and Propofol General Anesthesia on Postoperative Recovery Quality in Elderly Patients Undergoing Spinal Surgery: A Randomized Non-Inferiority Trial” [Letter]
Letter to the Editor Regarding "Effects of Desflurane and Propofol General Anesthesia on Postoperative Recovery Quality in Elderly Patients Undergoing Spinal Surgery: A Randomized Non-Inferiority Trial” [Letter]
Letter for the article Effects of Desflurane and Propofol General Anesthesia on Postoperative Recovery Quality in Elderly ...
Matrine Alleviates Sepsis-Induced Acute Lung Injury by Reinforcing NQO1/SLC7A11/GPX4-Associated Anti-Ferroptotic Defenses and Attenuating NF-κB-Driven Inflammation
Matrine Alleviates Sepsis-Induced Acute Lung Injury by Reinforcing NQO1/SLC7A11/GPX4-Associated Anti-Ferroptotic Defenses and Attenuating NF-κB-Driven Inflammation
Matrine alleviates SALI by reinforcing NQO1/SLC7A11/GPX4-associated anti-ferroptotic defenses and attenuating NF-κB-...
Anti-Lung Cancer Agent Discovery and Development: A Review of Cross-Platform Correlation Across in silico, Network Pharmacology, in vitro, and in vivo Assessments
Anti-Lung Cancer Agent Discovery and Development: A Review of Cross-Platform Correlation Across in silico, Network Pharmacology, in vitro, and in vivo Assessments
Synthesising reports evaluating anti–lung cancer agents across computational, cellular, and organism-level platforms...
Esketamine for Postoperative Anxiety After Major Abdominal Tumor Surgery: A Randomized Clinical Trial
Esketamine for Postoperative Anxiety After Major Abdominal Tumor Surgery: A Randomized Clinical Trial
Esketamine did not reduce postoperative anxiety versus placebo in patients with preoperative anxiety undergoing major abdo...
Monkeypox Virus Countermeasures: Vaccines, Antibodies, Drugs and Traditional Chinese Medicine
Monkeypox Virus Countermeasures: Vaccines, Antibodies, Drugs and Traditional Chinese Medicine
To explore mpox measures, therapies, and drug development including vaccines, antibodies, chemicals, natural monomers, TCM...
Integrated Metabolomic and Transcriptomic Analysis Suggests Potential Therapeutic Mechanism of Shengxian Decoction in Hypobaric Hypoxia-Induced Pulmonary Hypertension in SD Rats
Integrated Metabolomic and Transcriptomic Analysis Suggests Potential Therapeutic Mechanism of Shengxian Decoction in Hypobaric Hypoxia-Induced Pulmonary Hypertension in SD Rats
These findings suggest that Shengxian Decoction may ameliorate HPH partly through coordinated regulation of metabolic path...
Development and Validation of a UPLC–MS/MS Method for Simultaneous Quantification of Ensartinib and Its Major Metabolite M465 in Rat Plasma and Application to Pharmacokinetic Studies
Development and Validation of a UPLC–MS/MS Method for Simultaneous Quantification of Ensartinib and Its Major Metabolite M465 in Rat Plasma and Application to Pharmacokinetic Studies
This study developed a UPLC-MS/MS method for quantifying ensartinib and M465 in rat plasma and applied it to pharmacokinet...
First-in-Human Study of the PARP Inhibitor HWH340 in Advanced Solid Tumors with Enrichment for Homologous Recombination Repair Gene Mutations
First-in-Human Study of the PARP Inhibitor HWH340 in Advanced Solid Tumors with Enrichment for Homologous Recombination Repair Gene Mutations
Evaluating the safety, tolerability, pharmacokinetics, and clinical profiles of HWH340 tablets in patients with advanced s...
Folic Acid Therapy is Associated with a Lower Risk of Incident Diabetes and Better Glycemic Status in Patients with Coronary Heart Disease: Findings from a Multicenter Propensity Score–Matched Analysis
Folic Acid Therapy is Associated with a Lower Risk of Incident Diabetes and Better Glycemic Status in Patients with Coronary Heart Disease: Findings from a Multicenter Propensity Score–Matched Analysis
FA use was significantly associated with reduced new-onset diabetes risk and improved long-term glycemic status in CHD pat...
Key Experimental Therapeutics and Knowledge Gaps in Metabolic Dysfunction-Associated Steatohepatitis (MASH)
Key Experimental Therapeutics and Knowledge Gaps in Metabolic Dysfunction-Associated Steatohepatitis (MASH)
MASH therapeutics reviewed via liver cell-centered framework: hepatocyte, immune, stellate, niche, systemic targets demand...
Mechanism of Ferroptosis in Cardiovascular Disease and Its Regulation by Natural Compounds: A Narrative Review
Mechanism of Ferroptosis in Cardiovascular Disease and Its Regulation by Natural Compounds: A Narrative Review
Ferroptosis drives CVD pathology; 35 natural compounds and 19 TCM formulas modulate Nrf2/GPX4/iron pathways, yet clinical ...
Oliceridine versus Hydromorphone for Postoperative Analgesia: Interpreting the PONV Signal and the Limitations of Resting Pain as a Primary Endpoint [Response to Letter]
Oliceridine versus Hydromorphone for Postoperative Analgesia: Interpreting the PONV Signal and the Limitations of Resting Pain as a Primary Endpoint [Response to Letter]
Response to Letter in regards to Oliceridine Versus Hydromorphone for Postoperative Analgesia: Interpreting the PONV Signa...
Analgesic Efficacy of Continuous Bupivacaine Infusion versus Liposomal Bupivacaine in Parasacral Ischial Plane Block After Total Knee Arthroplasty: An Open-Label, Randomized, Controlled, Non-Inferiority Study
Analgesic Efficacy of Continuous Bupivacaine Infusion versus Liposomal Bupivacaine in Parasacral Ischial Plane Block After Total Knee Arthroplasty: An Open-Label, Randomized, Controlled, Non-Inferiority Study
A single-shot PIPB with LB met the prespecified non-inferiority criterion for pain relief compared with CPIPB after TKA, w...
Dose-Finding of Alfentanil for Hysteroscopy Under Remimazolam Sedation in Obese and Normal-Weight Patients: An Up-and-Down Trial
Dose-Finding of Alfentanil for Hysteroscopy Under Remimazolam Sedation in Obese and Normal-Weight Patients: An Up-and-Down Trial
Explored the 95% effective dose (ED95) of alfentanil for suppressing predefined procedural responses during hysteroscopy
Machine Learning Models Reveal New Risk Factors for Sub-/Supra-Therapeutic Concentrations of Sirolimus in Children with Vascular Anomalies
Machine Learning Models Reveal New Risk Factors for Sub-/Supra-Therapeutic Concentrations of Sirolimus in Children with Vascular Anomalies
To use machine learning models to predict the risk of sub- or supra-therapeutic sirolimus concentration in vascular anomal...
In vitro Screening for Synergistic Polymyxin B-Based Combinations Against KPC- Producing Carbapenem-Resistant Klebsiella pneumoniae
In vitro Screening for Synergistic Polymyxin B-Based Combinations Against KPC- Producing Carbapenem-Resistant Klebsiella pneumoniae
To evaluate the bactericidal effects of polymyxin B–based combination therapy with ten representative antibiotics ag...
Investigation of Potent Anti-Mycobacterium tuberculosis Agents Derived from Pyridine Derivatives Targeting the Enoyl Acyl Carrier Protein Reductase (InhA): Design, Synthesis, and Computational Analysis
Investigation of Potent Anti-Mycobacterium tuberculosis Agents Derived from Pyridine Derivatives Targeting the Enoyl Acyl Carrier Protein Reductase (InhA): Design, Synthesis, and Computational Analysis
Employing a hybrid pharmacophore strategy to design/synthesize thiazolidinone & thiazole derivatives conjugated to a p...
Effects of Voriconazole on the Safety, Pharmacokinetics and Pharmacodynamics of Ciprofol (HSK3486), a Novel Intravenous Anaesthetic, in Healthy Participants: A Prospective, Randomized, Crossover Clinical Trial
Effects of Voriconazole on the Safety, Pharmacokinetics and Pharmacodynamics of Ciprofol (HSK3486), a Novel Intravenous Anaesthetic, in Healthy Participants: A Prospective, Randomized, Crossover Clinical Trial
We investigated the effects of voriconazole on the safety, pharmacokinetics (PK) and pharmacodynamics (PD) of ciprofol.
From Methotrexate Resistance to Biologic and Targeted Pharmacotherapy: A Decade of Phase 4 Clinical Trials Evidence in Rheumatoid Arthritis
From Methotrexate Resistance to Biologic and Targeted Pharmacotherapy: A Decade of Phase 4 Clinical Trials Evidence in Rheumatoid Arthritis
Review on synthesize Phase 4 clinical trial evidence published between 2014 and 2024 evaluating therapeutic strategies.
Health Technology Assessment of Oxazolidinones for MRSA-Associated Complicated Skin and Soft Tissue Infections
Health Technology Assessment of Oxazolidinones for MRSA-Associated Complicated Skin and Soft Tissue Infections
Recommending tedizolid, linezolid, and contezolid for use in medical institutions during the introduction and application ...
Simultaneous Determination of Venetoclax and Posaconazole in Human Plasma by UPLC-MS/MS: Application to Therapeutic Drug Monitoring in Acute Myeloid Leukemia Patients
Simultaneous Determination of Venetoclax and Posaconazole in Human Plasma by UPLC-MS/MS: Application to Therapeutic Drug Monitoring in Acute Myeloid Leukemia Patients
Presenting an innovative method for the simultaneous quantification of venetoclax and posaconazole and demonstrating its a...
The Role of Microemulsions in Enhancing the Stability of Biopharmaceuticals
The Role of Microemulsions in Enhancing the Stability of Biopharmaceuticals
This review systematically summarizes the basic composition and structural characteristics of microemulsions
Intravitreal Ranibizumab versus Vitreous Lavage for Postoperative Vitreous Hemorrhage in Proliferative Diabetic Retinopathy: A Randomized Controlled Trial
Intravitreal Ranibizumab versus Vitreous Lavage for Postoperative Vitreous Hemorrhage in Proliferative Diabetic Retinopathy: A Randomized Controlled Trial
Comparing visual outcomes, hemorrhage clearance efficiency, & complications between intravitreal ranibizumab & vit...
Cardiac Myosin Activators in Heart Failure: Experimental Advances Amid Clinical Uncertainty
Cardiac Myosin Activators in Heart Failure: Experimental Advances Amid Clinical Uncertainty
Mechanistic rationale, translational evidence & pivotal clinical trials of these agents, integrating emerging work on ...
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