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Acid freezes uricolysis in addition to glycolysis: Utility of fluoride-EDTA-citrate tube in the measurement of uric acid for patients administered rasburicase
Acid freezes uricolysis in addition to glycolysis: Utility of fluoride-EDTA-citrate tube in the measurement of uric acid for patients administered rasburicase
BackgroundIn samples from patients administered rasburicase, ex vivo uricolysis leads to spuriously low uric acid results....
Faecal calprotectin is not necessarily required as a screen for significant bowel disease in primary care
Faecal calprotectin is not necessarily required as a screen for significant bowel disease in primary care
ObjectiveNICE recommends measurement of faecal haemoglobin (f-Hb) using faecal immunochemical test (FIT) when colorectal c...
Establishment of trimester-specific reference intervals for thyroid stimulating hormone and free thyroxine during pregnancy in southwest China by indirect method
Establishment of trimester-specific reference intervals for thyroid stimulating hormone and free thyroxine during pregnancy in southwest China by indirect method
ObjectiveA series of physiological changes in thyroid function occur during pregnancy and differ from those non-pregnant w...
Case report: Interference from isatuximab on serum protein electrophoresis prevented demonstration of complete remission in a myeloma patient
Case report: Interference from isatuximab on serum protein electrophoresis prevented demonstration of complete remission in a myeloma patient
Multiple myeloma is a haematological cancer caused by malignant plasma cells in the bone marrow that can result in organ d...
A survey of practice in the management of haemolysis, icterus and lipaemia in blood specimens in the United Kingdom and Republic of Ireland
A survey of practice in the management of haemolysis, icterus and lipaemia in blood specimens in the United Kingdom and Republic of Ireland
BackgroundHaemolysis, icterus and lipaemia (HIL) are common interferants in laboratory medicine, potentially impacting pat...
When should Lipoprotein(a) be measured?
When should Lipoprotein(a) be measured?
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Conflicting effects of haemolysis on plasma sodium and chloride are due to different haemolysis study protocols: A case for standardisation
Conflicting effects of haemolysis on plasma sodium and chloride are due to different haemolysis study protocols: A case for standardisation
BackgroundHaemolysis has been reported as having a positive, negative or no effect on plasma sodium (PNa) and chloride (PC...
Novel cholesterol efflux assay using immobilized liposome-bound gel beads: Confirmation and improvement for application in clinical laboratory
Novel cholesterol efflux assay using immobilized liposome-bound gel beads: Confirmation and improvement for application in clinical laboratory
ObjectivesCholesterol efflux capacity (CEC), an atheroprotective function of high-density lipoprotein, is expected to be a...
Population-specific adjusted calcium equations
Population-specific adjusted calcium equations
1. Perich, C, Ricós, C, Alvarez, V, et al. External quality assurance programs as a tool for verifying standardization of ...
A standard addition method to quantify serum lithium by inductively coupled plasma mass spectrometry
A standard addition method to quantify serum lithium by inductively coupled plasma mass spectrometry
BackgroundTherapeutic monitoring of lithium (Li) is important because of its narrow therapeutic range and therapeutic inde...
Co-analysis of pancreatic cyst fluid carcinoembryonic antigen and glucose with novel cut-off levels better distinguishes between mucinous and non-mucinous neoplastic pancreatic cystic lesions
Co-analysis of pancreatic cyst fluid carcinoembryonic antigen and glucose with novel cut-off levels better distinguishes between mucinous and non-mucinous neoplastic pancreatic cystic lesions
BackgroundPancreatic cyst fluid analysis plays an important role in distinguishing between mucinous and non-mucinous cyst ...
Predicting ionized hypocalcemia: External validation of an ionized calcium prediction model in patients with COVID-19 and renal failure
Predicting ionized hypocalcemia: External validation of an ionized calcium prediction model in patients with COVID-19 and renal failure
BackgroundIonized hypocalcemia is common in critically ill patients with COVID-19 and is associated with adverse outcomes....
Best practice in statistics: The use of log transformation
Best practice in statistics: The use of log transformation
The log transformation is often used to reduce skewness of a measurement variable. If, after transformation, the distribut...
Can patients with mild post-operative hyponatraemia following elective arthroplasty be discharged safely? A large-scale service evaluation suggests they can
Can patients with mild post-operative hyponatraemia following elective arthroplasty be discharged safely? A large-scale service evaluation suggests they can
BackgroundPost-operative hyponatraemia is common following arthroplasty. Clinical hyponatraemia guidelines lack detail on ...
Tumour markers of prostate cancer: The post-PSA era
Tumour markers of prostate cancer: The post-PSA era
Although PSA-based prostate cancer (PCa) screening had a positive impact in reducing PCa mortality, it also led to overdia...
Comparison of ultra-performance liquid chromatography and ARK immunoassay for therapeutic drug monitoring of voriconazole
Comparison of ultra-performance liquid chromatography and ARK immunoassay for therapeutic drug monitoring of voriconazole
BackgroundTherapeutic drug monitoring (TDM) of voriconazole is recommended for personalizing doses. The objective of this ...
Stability of maternal serum free β-hCG following whole blood sample transit: First trimester Down’s syndrome screening in Scotland
Stability of maternal serum free β-hCG following whole blood sample transit: First trimester Down’s syndrome screening in Scotland
BackgroundMaternal serum free beta human chorionic gonadotrophin (free β-hCG) is used as a biomarker in first trimester sc...
UKMedLab2021 conference—building a new platform for the future
UKMedLab2021 conference—building a new platform for the future
Access to society journal content varies across our titles. If you have access to a journal via a society or association ...
Machine learning predictive models of LDL-C in the population of eastern India and its comparison with directly measured and calculated LDL-C
Machine learning predictive models of LDL-C in the population of eastern India and its comparison with directly measured and calculated LDL-C
BackgroundLDL-C is a strong risk factor for cardiovascular disorders. The formulas used to calculate LDL-C showed varying ...
A UK national audit of the laboratory investigation of phaeochromocytoma and paraganglioma
A UK national audit of the laboratory investigation of phaeochromocytoma and paraganglioma
BackgroundPhaeochromocytomas and paragangliomas (PPGL) are catecholamine secreting tumours associated with significant mor...
Samples spiked with pituitary-derived thyroid-stimulating hormone may disguise the extent of differences between thyroid-stimulating hormone assays
Samples spiked with pituitary-derived thyroid-stimulating hormone may disguise the extent of differences between thyroid-stimulating hormone assays
BackgroundA large discordance in the diagnosis and potential management of hypothyroidism using Abbott and Roche thyroid a...
Comparison of ultra-performance liquid chromatography and ARKTM immunoassay for therapeutic drug monitoring of voriconazole
Comparison of ultra-performance liquid chromatography and ARKTM immunoassay for therapeutic drug monitoring of voriconazole
BackgroundTherapeutic drug monitoring (TDM) of voriconazole is recommended for personalizing doses. The objective of this ...
LC-MS/MS the First 20 years: A Personal View
LC-MS/MS the First 20 years: A Personal View
1. Marshall, DJ, Kim, JJ, Brand, S, et al. Assessment of tacrolimus and creatinine concentration collected using Mitra mic...
Tumour markers in prostate cancer: The post-prostate-specific antigen era
Tumour markers in prostate cancer: The post-prostate-specific antigen era
Although prostate-specific antigen-based prostate cancer screening had a positive impact in reducing prostate cancer morta...
Lithium heparin interference in the Abbott enzymatic creatinine assay: the significance of under-filled tubes
Lithium heparin interference in the Abbott enzymatic creatinine assay: the significance of under-filled tubes
BackgroundSpuriously high results using the Abbott Architect enzymatic creatinine assay were noted to be particularly asso...
Reducing the number of unnecessary laboratory tests within hospital through the use of educational interventions
Reducing the number of unnecessary laboratory tests within hospital through the use of educational interventions
BackgroundThe growing number of laboratory investigation requests is placing an increased burden upon NHS resources. Aroun...
A rapid liquid chromatography-tandem mass spectrometry method for the analysis of urinary 5-hydroxyindoleacetic acid (5-HIAA) that incorporates a 13C-labelled internal standard
A rapid liquid chromatography-tandem mass spectrometry method for the analysis of urinary 5-hydroxyindoleacetic acid (5-HIAA) that incorporates a 13C-labelled internal standard
BackgroundUrinary 5-hydroxyindoleacetic acid (5-HIAA) is a first-line investigation for gastrointestinal neuroendocrine tu...
Serum GP88 as a predictive biomarker for hepatocellular carcinoma in patients with viral hepatitis C after direct-acting antiviral agents
Serum GP88 as a predictive biomarker for hepatocellular carcinoma in patients with viral hepatitis C after direct-acting antiviral agents
BackgroundProgranulin (GP88) is an 88-kDa glycoprotein growth factor with important biological effects in tumorigenesis an...
Repeat measurements on patient samples identifies unpredictable and poorly reproducible cardiac troponin results with a high-sensitivity cardiac troponin assay
Repeat measurements on patient samples identifies unpredictable and poorly reproducible cardiac troponin results with a high-sensitivity cardiac troponin assay
Access to society journal content varies across our titles. If you have access to a journal via a society or association ...
Clinical performance of the Elecsys® anti-SARS-CoV-2 combined in an algorithm with two specific anti-IgG immunoassays for the evaluation of the serological response of patients with COVID-19 in a population with a high prevalence of infection
Clinical performance of the Elecsys® anti-SARS-CoV-2 combined in an algorithm with two specific anti-IgG immunoassays for the evaluation of the serological response of patients with COVID-19 in a population with a high prevalence of infection
BackgroundAnti-SARS-CoV-2 antibodies have been used in the study of the immune response in infected patients. However, dif...
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