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Variceal band ligation and carvedilol: together forever, or not?
Variceal band ligation and carvedilol: together forever, or not?
We extend our congratulations to Tevethia et al for their recently published ‘CAVARLY trial’, which suggests the combinati...
Extending inflamed-class signature to predict immune checkpoint inhibitor-based combination therapy in hepatocellular carcinoma
Extending inflamed-class signature to predict immune checkpoint inhibitor-based combination therapy in hepatocellular carcinoma
Recently, we were intrigued by a recent study by Montironi et al,1 in which they discovered that an inflamed subclass in h...
Environmental and healthcare trade-offs between single-use and reusable gastroscopes
Environmental and healthcare trade-offs between single-use and reusable gastroscopes
We would like to offer some critical observations regarding the recent article published on the environmental impact of si...
Unravelling lipidomic disruptions across multiple tissues in Chd8-mutant ASD mice through integration of lipidomics and single-cell transcriptomics
Unravelling lipidomic disruptions across multiple tissues in Chd8-mutant ASD mice through integration of lipidomics and single-cell transcriptomics
With great interest, we read the article by Lou et al,1 who reported deviated gut microbiota in children with autism spect...
High-risk varices in patients with Child-Pugh-Turcotte B and C: consider band ligation with carvedilol for preventing first variceal bleeding, especially in patients with MASLD-associated cirrhosis
High-risk varices in patients with Child-Pugh-Turcotte B and C: consider band ligation with carvedilol for preventing first variceal bleeding, especially in patients with MASLD-associated cirrhosis
International guidelines recommend that primary prophylaxis of varices in patients with cirrhosis be either non-selective ...
Is the biogeography of the mucosa-associated microbiota a key factor affecting primary sclerosing cholangitis disease course and treatment?
Is the biogeography of the mucosa-associated microbiota a key factor affecting primary sclerosing cholangitis disease course and treatment?
We have read with interest the contribution by Bedke et al,1 reporting changes in the stool microbiota associated with pri...
Targeting TL1A and DR3: the new frontier of anti-cytokine therapy in IBD
Targeting TL1A and DR3: the new frontier of anti-cytokine therapy in IBD
TNF-like cytokine 1A (TL1A) and its functional receptor, death-domain receptor 3 (DR3), are members of the TNF and TNFR su...
NNMT enriches for AQP5+ cancer stem cells to drive malignant progression in early gastric cardia adenocarcinoma
NNMT enriches for AQP5+ cancer stem cells to drive malignant progression in early gastric cardia adenocarcinoma
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Getting off tract: contributions of intraorgan microbiota to cancer in extraintestinal organs
Getting off tract: contributions of intraorgan microbiota to cancer in extraintestinal organs
The gastrointestinal ecosystem has received the most attention when examining the contributions of the human microbiome to...
Reflux conditions induce E-cadherin cleavage and EMT via APE1 redox function in oesophageal adenocarcinoma
Reflux conditions induce E-cadherin cleavage and EMT via APE1 redox function in oesophageal adenocarcinoma
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Novel prognostic biomarkers in decompensated cirrhosis: a systematic review and meta-analysis
Novel prognostic biomarkers in decompensated cirrhosis: a systematic review and meta-analysis
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Cleara...
Diagnostic dilemma: a patient with diarrhoea
Diagnostic dilemma: a patient with diarrhoea
A Sudanese man in his early 40s was admitted to our tertiary healthcare centre with a 3-month history of abdominal pain, f...
FAK suppresses antigen processing and presentation to promote immune evasion in pancreatic cancer
FAK suppresses antigen processing and presentation to promote immune evasion in pancreatic cancer
IntroductionThe contribution of pancreatic cancer to global cancer-related mortality continues to increase, with an almost...
Wheat proteins as triggers of central nervous system inflammation
Wheat proteins as triggers of central nervous system inflammation
The role of diet in the initiation and progression of disease is one of the most exciting areas of research nowadays. Alth...
FAK scaffolds immune escape in pancreatic cancer
FAK scaffolds immune escape in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease in urgent need of improved therapy. A characteristic feat...
More than shots in the dark: driving vaccine efficacy in cirrhosis
More than shots in the dark: driving vaccine efficacy in cirrhosis
In advanced stages of the disease, liver cirrhosis is considered a systemic disease as its complications manifest on vario...
Thermal ablation after endoscopic mucosal resection of large colorectal polyps: not only the margins, but also the base?
Thermal ablation after endoscopic mucosal resection of large colorectal polyps: not only the margins, but also the base?
MessageThermal ablation of resection margins has been shown to reduce recurrence after endoscopic mucosal resection (EMR) ...
Monocyte phenotypic liquid biopsy for NASH and liver fibrosis diagnosis: a new kid on the block
Monocyte phenotypic liquid biopsy for NASH and liver fibrosis diagnosis: a new kid on the block
Clinical diagnosis, selection of patients in non-alcoholic steatohepatitis (NASH) clinical trials and evaluation of both d...
Three double-dose reinforced hepatitis B revaccination scheme for patients with cirrhosis unresponsive to the standard regimen: an open-label randomised clinical trial
Three double-dose reinforced hepatitis B revaccination scheme for patients with cirrhosis unresponsive to the standard regimen: an open-label randomised clinical trial
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British Society of Gastroenterology guidelines for the diagnosis and management of cholangiocarcinoma
British Society of Gastroenterology guidelines for the diagnosis and management of cholangiocarcinoma
Executive summary and list of recommendationsThe management of CCA should be undertaken at centres with expertise across a...
Crohns-associated invariant T cells (CAITs) recognise small sulfonate molecules on CD1d
Crohns-associated invariant T cells (CAITs) recognise small sulfonate molecules on CD1d
In the recent study by Rosati et al, we described a novel unconventional T cell population enriched in the peripheral bloo...
Smart capsules for sensing and sampling the gut: status, challenges and prospects
Smart capsules for sensing and sampling the gut: status, challenges and prospects
IntroductionThe gastrointestinal (GI) tract has historically been a region of intense interest for the assessment of healt...
Akkermansia muciniphila derived tripeptide jams the gear of sepsis, inflammation and mortality
Akkermansia muciniphila derived tripeptide jams the gear of sepsis, inflammation and mortality
Sepsis constitutes a global burden on medical care and accounts for nearly 20% of reported global mortality.1 The developm...
Atrophic autoimmune gastritis: 'a muddled or misguided core concept compromises our overall comprehension of the problem
Atrophic autoimmune gastritis: 'a muddled or misguided core concept compromises our overall comprehension of the problem
We thank Lahner et al for their interest in our study: considering their extensive experience in the field of gastric auto...
UK and Ireland Joint Advisory Group (JAG) consensus statements for training and certification in diagnostic endoscopic ultrasound (EUS)
UK and Ireland Joint Advisory Group (JAG) consensus statements for training and certification in diagnostic endoscopic ultrasound (EUS)
MethodsGuideline developmentA modified Delphi process was used to develop consensus-based recommendations on training and ...
Predicting residual neoplasia after a non-curative gastric ESD: validation and modification of the eCura system in the Western setting: the W-eCura score
Predicting residual neoplasia after a non-curative gastric ESD: validation and modification of the eCura system in the Western setting: the W-eCura score
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Cleara...
Non-alcoholic fatty liver disease (NAFLD) is associated with an increased incidence of extrahepatic cancer
Non-alcoholic fatty liver disease (NAFLD) is associated with an increased incidence of extrahepatic cancer
With great interest, we read the meta-analysis of observational cohort studies by Mantovani et al 1 providing significant ...
Letter to the editor: Helicobacter pylori eradication - the proof is not in the symptoms
Letter to the editor: Helicobacter pylori eradication - the proof is not in the symptoms
We read with interest the excellent and comprehensive British Society of Gastroenterology guidelines on the management of ...
Not all that is corpus restricted is necessarily autoimmune
Not all that is corpus restricted is necessarily autoimmune
We read with interest the paper by Rugge et al on the long-term natural history in Helicobacter pylori (Hp)-negative patie...
Carbon footprint of gastroenterology practice
Carbon footprint of gastroenterology practice
The healthcare sector is a major contributor to greenhouse gas (GHG) emissions,1 contributing to global warming and thereb...
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