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PARP1-targeted alpha therapy enhances target expression
PARP1-targeted alpha therapy enhances target expression
We investigated whether [211At]PTT therapy induces transient upregulation of PARP1 expression in neuroblastoma xenografts ...
Clinical effect of three-dimensional left ventricular mechanical dyssynchrony and cardiac sympathetic denervation in systolic heart failure risk-stratified by left ventricular ejection fraction and QRS duration
Clinical effect of three-dimensional left ventricular mechanical dyssynchrony and cardiac sympathetic denervation in systolic heart failure risk-stratified by left ventricular ejection fraction and QRS duration
The left ventricular ejection fraction (LVEF) and QRS duration (QRSd) are prognostic factors in patients with systolic hea...
Augmentation of [18F]-C-SNAT4 PET imaging of apoptosis after radiotherapy using a cold mixing strategy
Augmentation of [18F]-C-SNAT4 PET imaging of apoptosis after radiotherapy using a cold mixing strategy
Positron Emission Tomography (PET) imaging can monitor cancer treatment response by non-invasively detecting apoptosis in ...
Macrophage mannose receptor CD206-targeted PET imaging in experimental acute myocardial infarction
Macrophage mannose receptor CD206-targeted PET imaging in experimental acute myocardial infarction
The macrophage mannose receptor (CD206) is expressed predominantly on the surface of M2-type macrophages, which play a rol...
Preclinical evaluation of glycan-targeting monoclonal antibodies for bimodal near-infrared fluorescence and photoacoustic imaging of gastrointestinal cancers
Preclinical evaluation of glycan-targeting monoclonal antibodies for bimodal near-infrared fluorescence and photoacoustic imaging of gastrointestinal cancers
Near-infrared fluorescence (NIRF) imaging assists surgeons intraoperatively to achieve radical resection of malignant tiss...
PSMA imaging as a non-invasive tool to monitor inducible gene expression in vivo
PSMA imaging as a non-invasive tool to monitor inducible gene expression in vivo
Das A, Zhou X, Metz SW, Vink MA, Berkhout B. Selecting the optimal Tet-on system for doxycycline-inducible gene expression...
[68 Ga]Ga-FAPI-04 PET/CT may be a predictor for early treatment response in rheumatoid arthritis
[68 Ga]Ga-FAPI-04 PET/CT may be a predictor for early treatment response in rheumatoid arthritis
The identification of biomarkers predicting the treatment response of rheumatoid arthritis (RA) is important. [68&nbsp...
ImmunoPET provides a novel way to visualize the CD103+ tissue-resident memory T cell to predict the response of immune checkpoint inhibitors
ImmunoPET provides a novel way to visualize the CD103+ tissue-resident memory T cell to predict the response of immune checkpoint inhibitors
Immune checkpoint inhibitors (ICIs) have made significant progress in oncotherapy improving survival of patients. However,...
Effects of isoflurane anaesthesia depth and duration on renal function measured with [99mTc]Tc-mercaptoacetyltriglycine SPECT in mice
Effects of isoflurane anaesthesia depth and duration on renal function measured with [99mTc]Tc-mercaptoacetyltriglycine SPECT in mice
The influence of anaesthetic depth and the potential influence of different anaesthetic beds and thus different handling p...
Comparison of tracer kinetic models for 68Ga-PSMA-11 PET in intermediate-risk primary prostate cancer patients
Comparison of tracer kinetic models for 68Ga-PSMA-11 PET in intermediate-risk primary prostate cancer patients
68Ga-PSMA-11 positron emission tomography enables the detection of primary, recurrent, and metastatic prostate cancer. Reg...
18F-FDG PET/CT-based deep learning radiomics predicts 5-years disease-free survival after failure to achieve pathologic complete response to neoadjuvant chemotherapy in breast cancer
18F-FDG PET/CT-based deep learning radiomics predicts 5-years disease-free survival after failure to achieve pathologic complete response to neoadjuvant chemotherapy in breast cancer
This study aimed to assess whether a combined model incorporating radiomic and depth features extracted from PET/CT can pr...
Single time point quantitation of cerebral glucose metabolism by FDG-PET without arterial sampling
Single time point quantitation of cerebral glucose metabolism by FDG-PET without arterial sampling
Until recently, quantitation of the net influx of 2-[18F]fluorodeoxyglucose (FDG) to brain (Ki) and the cerebrometabolic r...
[18F]FDG PET-MR characterization of aortitis in the IL1rn−/− mouse model of giant-cell arteritis
[18F]FDG PET-MR characterization of aortitis in the IL1rn−/− mouse model of giant-cell arteritis
Metabolic imaging is routinely used to demonstrate aortitis in patients with giant-cell arteritis. We aimed to investigate...
Development of [89Zr]Zr-hCD103.Fab01A and [68Ga]Ga-hCD103.Fab01A for PET imaging to noninvasively assess cancer reactive T cell infiltration: Fab-based CD103 immunoPET
Development of [89Zr]Zr-hCD103.Fab01A and [68Ga]Ga-hCD103.Fab01A for PET imaging to noninvasively assess cancer reactive T cell infiltration: Fab-based CD103 immunoPET
CD103 is an integrin specifically expressed on the surface of cancer-reactive T cells. The number of CD103+ T cells signif...
Biological efficacy of simulated radiolabeled Lipiodol® ultra-fluid and microspheres for various beta emitters: study based on VX2 tumors
Biological efficacy of simulated radiolabeled Lipiodol® ultra-fluid and microspheres for various beta emitters: study based on VX2 tumors
Radioembolization is one therapeutic option for the treatment of locally early-stage hepatocellular carcinoma. The aim of ...
Assessment of hypoxia and oxidative-related changes in a lung-derived brain metastasis model by [64Cu][Cu(ATSM)] PET and proteomic studies
Assessment of hypoxia and oxidative-related changes in a lung-derived brain metastasis model by [64Cu][Cu(ATSM)] PET and proteomic studies
Brain metastases (BM) are the most frequent malignant brain tumors. The aim of this study was to characterize the tumor mi...
Adenosine-induced splenic switch-off on [15O]H2O PET perfusion for the assessment of vascular vasodilatation
Adenosine-induced splenic switch-off on [15O]H2O PET perfusion for the assessment of vascular vasodilatation
Splenic switch-off (SSO) is a marker of adequate adenosine-induced vasodilatation on cardiac magnetic resonance perfusion ...
Characterisation of a novel [18F]FDG brain PET database and combination with a second database for optimising detection of focal abnormalities, using focal cortical dysplasia as an example
Characterisation of a novel [18F]FDG brain PET database and combination with a second database for optimising detection of focal abnormalities, using focal cortical dysplasia as an example
Brain [18F]FDG PET is used clinically mainly in the presurgical evaluation for epilepsy surgery and in the differential di...
Heterogeneity of prostate-specific membrane antigen (PSMA) and PSMA-ligand uptake detection combining autoradiography and postoperative pathology in primary prostate cancer
Heterogeneity of prostate-specific membrane antigen (PSMA) and PSMA-ligand uptake detection combining autoradiography and postoperative pathology in primary prostate cancer
Targeting prostate-specific membrane antigen (PSMA) has been highly successful for imaging and treatment of prostate cance...
Head-to-head comparison of relative cerebral blood flow derived from dynamic [18F]florbetapir and [18F]flortaucipir PET in subjects with subjective cognitive decline
Head-to-head comparison of relative cerebral blood flow derived from dynamic [18F]florbetapir and [18F]flortaucipir PET in subjects with subjective cognitive decline
Dynamic PET imaging studies provide accurate estimates of specific binding, but also measure the relative tracer delivery ...
Effects of novel androgen receptor signaling inhibitors on PSMA PET signal intensity in patients with castrate-resistant prostate cancer: a prospective exploratory serial imaging study
Effects of novel androgen receptor signaling inhibitors on PSMA PET signal intensity in patients with castrate-resistant prostate cancer: a prospective exploratory serial imaging study
PSMA expression is influenced by hormonal status. We evaluated changes in PSA and whole-body 68Ga-PSMA-11 PET/CT (WB-PSMA ...
An update on the use of image-derived input functions for human PET studies: new hopes or old illusions?
An update on the use of image-derived input functions for human PET studies: new hopes or old illusions?
The need for arterial blood data in quantitative PET research limits the wider usability of this imaging method in clinica...
Quantitative and clinical implications of the EARL2 versus EARL1 [18F]FDG PET-CT performance standards in head and neck squamous cell carcinoma
Quantitative and clinical implications of the EARL2 versus EARL1 [18F]FDG PET-CT performance standards in head and neck squamous cell carcinoma
The EANM Research Ltd. (EARL) guidelines give recommendations for harmonization of [18F]FDG PET-CT image acquisition and r...
Baseline 18F-FDG PET/CT radiomics for prognosis prediction in diffuse large B cell lymphoma
Baseline 18F-FDG PET/CT radiomics for prognosis prediction in diffuse large B cell lymphoma
Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma in adults. Standard treatment inc...
Value of 18F-FDG-PET/CT radiomics combined with clinical variables in the differential diagnosis of malignant and benign vertebral compression fractures
Value of 18F-FDG-PET/CT radiomics combined with clinical variables in the differential diagnosis of malignant and benign vertebral compression fractures
Vertebral compression fractures (VCFs) are common clinical problems that arise from various reasons. The differential diag...
Myocardial glucose suppression may interfere with the detection of inflammatory cells with FDG-PET as suggested in a canine model of myocardial infarction
Myocardial glucose suppression may interfere with the detection of inflammatory cells with FDG-PET as suggested in a canine model of myocardial infarction
After myocardial infarction, fibrosis and an ongoing dysregulated inflammatory response have been shown to lead to adverse...
Sensitivity of an AI method for [18F]FDG PET/CT outcome prediction of diffuse large B-cell lymphoma patients to image reconstruction protocols
Sensitivity of an AI method for [18F]FDG PET/CT outcome prediction of diffuse large B-cell lymphoma patients to image reconstruction protocols
Convolutional neural networks (CNNs), applied to baseline [18F]-FDG PET/CT maximum intensity projections (MIPs), show pote...
Reduced hematopoietic-inflammatory response and worse outcomes in patients with recurrent myocardial infarction in comparison with primary myocardial infarction
Reduced hematopoietic-inflammatory response and worse outcomes in patients with recurrent myocardial infarction in comparison with primary myocardial infarction
Recurrent myocardial infarction (RMI) portends an unfavorable outcome, which might be related to diminished hematopoietic-...
Dispersion-corrected extracorporeal arterial input functions in PET studies of mice: a comparison to intracorporeal microprobe measurements
Dispersion-corrected extracorporeal arterial input functions in PET studies of mice: a comparison to intracorporeal microprobe measurements
Kinetic modelling of dynamic PET typically requires knowledge of the arterial radiotracer concentration (arterial input fu...
Assessment of resting myocardial blood flow in regions of known transmural scar to confirm accuracy and precision of 3D cardiac positron emission tomography
Assessment of resting myocardial blood flow in regions of known transmural scar to confirm accuracy and precision of 3D cardiac positron emission tomography
Composite invasive and non-invasive data consistently demonstrate that resting myocardial blood flow (rMBF) in regions of ...
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