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RNA modifications: one ring to map them all
RNA modifications: one ring to map them all
Direct RNA sequencing by the Oxford nanopore technology enabled simultaneous mapping of different RNA modifications on the...
Elucidating structure–function relationships in the mammalian nucleolus
Elucidating structure–function relationships in the mammalian nucleolus
The nucleolus is the site of ribosomal RNA synthesis and ribosome biogenesis. Advances in high-resolution imaging and next...
Emerging evidence for a cooperative pathway of Hedgehog release
Emerging evidence for a cooperative pathway of Hedgehog release
All Hedgehog (Hh) morphogens undergo dual lipidation during biosynthesis. This process renders them insoluble; however, wi...
Principles and mechanisms of plant acclimation to heat stress
Principles and mechanisms of plant acclimation to heat stress
Plants are able to acclimate to heat stress (HS) at the level of individual cells and the whole organism. With extreme tem...
Overview of circular RNA databases and other resources
Overview of circular RNA databases and other resources
Circular RNAs (circRNAs) form a distinct class of RNA molecules with roles in diverse biological processes. The characteri...
Effortless immortalization of primary mouse fibroblasts
Effortless immortalization of primary mouse fibroblasts
A 2003 study established that oxidative DNA damage can drive cell senescence of mouse fibroblasts, and that culturing thes...
Caveolae mechanics in cellular functions and disease
Caveolae mechanics in cellular functions and disease
Caveolae are small, cup-shaped invaginations of the plasma membrane that are enriched in caveolin and cavin proteins, chol...
Tight junction structure, assembly and (dys)function
Tight junction structure, assembly and (dys)function
Tight junctions (TJs) regulate paracellular permeability, cell polarity and cell mechanics of barrier-forming tissues. Thi...
The centromere as a tag of self-DNA
The centromere as a tag of self-DNA
Intriguing findings in yeast suggested that centromeres ‘tag’ DNA as self and allow its condensation during mi...
Silencing centromeres with age
Silencing centromeres with age
Centromeres are silenced in aged cells by the epigenetic downregulation of centromere transcription.
Expanding the genetic code for site-specific lysine lactylation
Expanding the genetic code for site-specific lysine lactylation
In this Tools of the Trade article, Zong (Zhou lab) describes how using genetic code expansion enabled the precise incorpo...
The bystander effect of pyroptosis
The bystander effect of pyroptosis
This study uncovered how extracellular vesicles carrying gasdermin D pores propagate pyroptosis between cells, exacerbatin...
Unravelling the complexity of gene regulation through multiplexed protein mapping
Unravelling the complexity of gene regulation through multiplexed protein mapping
In this Tools of the Trade article, Goronzy (Guttman lab) describes the development of ChIP-DIP, a high-throughput, split-...
Regulation and function of insulin and insulin-like growth factor receptor signalling
Regulation and function of insulin and insulin-like growth factor receptor signalling
Receptors of insulin and insulin-like growth factors (IGFs) are receptor tyrosine kinases whose signalling controls multip...
Profiling the disordered proteome in cells using a chemical tag
In this Tools of the Trade article, Zhang and Owyong (Hong lab) discuss the development of a fluorescent probe that binds ...
Improving chemical reprogramming strategies
Improving chemical reprogramming strategies
In this Tools of the Trade article, Wang and Cheng (Deng Lab) describe an improved protocol for the generation of human pl...
The molecular basis of translation initiation and its regulation in eukaryotes
The molecular basis of translation initiation and its regulation in eukaryotes
The regulation of gene expression is fundamental for life. Whereas the role of transcriptional regulation of gene expressi...
Does species-specific alternative splicing make us human?
Florian Heyd describes a paper that pointed towards alternative splicing as a driver of human cognitive abilities.
Lysosomes as coordinators of cellular catabolism, metabolic signalling and organ physiology
Lysosomes as coordinators of cellular catabolism, metabolic signalling and organ physiology
Every cell must satisfy basic requirements for nutrient sensing, utilization and recycling through macromolecular breakdow...
Local and systemic mechanisms that control the hair follicle stem cell niche
Local and systemic mechanisms that control the hair follicle stem cell niche
Hair follicles are essential appendages of the mammalian skin, as hair performs vital functions of protection, thermoregul...
Extended heterochronic parabiosis as an approach to study rejuvenation
In this Tools of the Trade article, Bohan Zhang (Gladyshev lab) discusses how the use of extended heterochronic parabiosis...
Senescent cells support limb regeneration
Yu et al. identify senescent cells as important players in the regeneration of complex structures.
The nuance in DNA and transcription factor interactions
The nuance in DNA and transcription factor interactions
Emily Wong describes a study that provided a quantitative methodology for analyzing ChIP experiments and shifted ...
Probing cytoskeletal remodelling by cutting and marking filaments
In this Tools of the Trade article, Manuela Richter (Dumont lab) describes a method to probe mechanisms of cytoskeletal ne...
The molecular basis for cellular function of intrinsically disordered protein regions
The molecular basis for cellular function of intrinsically disordered protein regions
Intrinsically disordered protein regions exist in a collection of dynamic interconverting conformations that lack a stable...
Mechanisms of SNARE proteins in membrane fusion
Mechanisms of SNARE proteins in membrane fusion
Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) are a family of small conserved eukaryotic...
Challenges and opportunities in macromolecular structure determination
Embedded within the complexity of biological systems lies a formidable task: deciphering the intricate architecture of mac...
Mechanism of sperm mtDNA elimination
Mechanism of sperm mtDNA elimination
Phosphorylation of the mitochondrial DNA (mtDNA) maintenance factor TFAM during spermatogenesis prevents its import into m...
ERMES — from myths to molecules
Ernst and Renne highlight two papers, one that discovered and another that structurally defined the ER–mitochondria ...
Activation of human endogenous retroviruses and its physiological consequences
Activation of human endogenous retroviruses and its physiological consequences
Human endogenous retroviruses (HERVs) are abundant sequences that persist within the human genome as remnants of ancient r...
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