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Chondrocytes versus chondroprogenitors for auricular cartilage repair: a critical comparative review
BackgroundAuricular cartilage defects, whether congenital or acquired, present a significant reconstructive challenge. Aut...
Effects of leukoreduction and storage duration on whole blood hemostatic function: a prospective ex vivo observational study
BackgroundWhole blood (WB) resuscitation is a critical component of trauma care. Leukoreduction (LR) is commonly employed ...
Zfhx3 is required for proper spindle assembly and chromosome segregation during oocyte meiosis I in mice
BackgroundZFHX3, a multifunctional transcription factor, plays pivotal roles in a variety of physiological and pathologica...
From arthritis to erectile dysfunction: potential pathophysiological mechanisms and multidisciplinary integrated management
This review systematically examines the underlying mechanisms linking erectile dysfunction (ED) with arthritis and explore...
Beyond the genome: clinical challenges in diagnosing LONP1-related mitochondrial disorders
BackgroundLONP1 encodes an ATP-dependent protease essential for maintaining mitochondrial homeostasis. LONP1 variants have...
Multi omics network toxicology and in vitro experiments elucidate the role of benzo [a] pyrene in prostate cancer
BackgroundIn recent years, growing attention has been paid to the role of Benzo [a]pyrene (BaP) in the development and pro...
Benchmarking large language models for congenital cataract parent counseling: safety, readability, and knowledge translation of developmental and genetic information
BackgroundCongenital cataract (CC) is a time-critical cause of preventable childhood visual impairment. After diagnosis, p...
High dopamine impairs early neuronal identity and morphology in human hippocampal progenitor cells
Adult hippocampal neurogenesis (AHN) supports learning, memory, and emotional regulation, and is regulated by intrinsic an...
Dynamic changes in excitability and viability of sporadic and SOD1-related amyotrophic lateral sclerosis iPSC-derived motor neurons
ObjectiveTo explore the dynamic changes in excitability and viability of induced pluripotent stem cells (iPSC)-derived mot...
Extracellular vesicles and viruses share a nuclear entry pathway in cancer and infection
The concept that small extracellular vesicles (sEVs; 30-200 nm in diameter) can deliver cargo to the nucleus has gained in...
Age-related lncRNA alterations of SDHAP2_miR-17-5p/miR-20b-5p_RAB11FIP1 ceRNA network in donor-derived human limbal epithelial cells
BackgroundLimbal epithelial cells (LECs) play a crucial role in preserving ocular surface stability and ensuring the norma...
Enterococcus-driven metabolite-host gene networks in IBD-associated colorectal carcinogenesis: integrative multi-omics and experimental validation
BackgroundThis study aims to elucidate the role of Enterococcusin the progression from inflammatory bowel disease to color...
The regulation of pedicle initiation by androgens in sika deer (Cervus nippon)
BackgroundDeer antlers have the potential to contribute to a range of novel biomedical models. Although androgen is undoub...
The role of extracellular vesicles in the context of (inter‐)cellular communication contributing to adipose tissue dysfunction in lipedema
Lipedema is a chronic, female-predominant disorder of subcutaneous adipose tissue characterized by disproportionate fat ex...
The role of extracellular vesicles in the transport and regulation of novel inflammatory mediators in IBD and its associated CRC
Inflammatory bowel disease (IBD), comprising ulcerative colitis (UC) and Crohn’s disease (CD), is a chronic inflammation o...
The role of platelet derivatives in regenerative medicine: biological foundations and translational perspectives
Platelet derivatives have become a central strategy in regenerative medicine due to their capacity to concentrate autologo...
Editorial: Advancements in solid tumor immunotherapy: enhancing efficacy and overcoming resistance
Immunotherapy has reshaped the treatment landscape of many cancers, yet durable benefit in solid tumors remains limited to...
Endogenous mediators in regulating primary dysmenorrhea
Primary dysmenorrhea is currently an unresolved public health problem worldwide, which suffers the patients comprehensive ...
Chronic kidney disease as an active driver of digestive tract tumors: mechanistic insights and emerging management strategies
Digestive tract tumors (DTT), particularly gastric cancer (GC) and colorectal cancer (CRC), remain among the leading cause...
The role of exercise-mediated mitochondrial quality control remodeling in aging
Aging is intimately associated with multisystem functional decline and an increased risk of chronic diseases. A pivotal cy...
Advancements in pseudouridine modifying enzyme and cancer
Advancements in pseudouridine modifying enzyme and cancer
1 IntroductionPseudouridine (Ψ) is a post-transcriptional modification of RNA that plays a role in epigenetics. Epigenetic...
Transcriptomics as a predictor of biopharmaceutically favourable glycan profiles
IntroductionCell line development (CLD) is a pivotal step in biopharmaceutical manufacturing, focused on developing and id...
Understanding the impact of ER stress on lung physiology
1 IntroductionThe process of aging is intricate, involving the gradual decline of tissues and organs throughout the body, ...
FTO in health and disease
FTO in health and disease
1 Discovering FTO and its functionIn 1999, Fto was identified as one of the several genes deleted in mice with the Ft (Fus...
Ferroptosis and its role in osteoarthritis: mechanisms, biomarkers, and therapeutic perspectives
Ferroptosis and its role in osteoarthritis: mechanisms, biomarkers, and therapeutic perspectives
1 IntroductionOsteoarthritis (OA) is a highly prevalent and destructive degenerative joint disease, affecting approximatel...
Differentiation ability of hematopoietic stem cells and mesenchymal stem cells isolated from human peripheral blood
IntroductionHematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs) are the major stem cells of the bone marrow ...
Retinal glia in myopia: current understanding and future directions
1 IntroductionThe prevalence of myopia continues to increase, such that it is expected to affect nearly half the global po...
Extracellular vesicles derived from dental follicle stem cells regulate tooth eruption by inhibiting osteoclast differentiation
1 IntroductionTooth eruption refers to the movement of a tooth from its developmental position through the bone and overly...
Zebrafish as a model system for studying reproductive diseases
1 IntroductionIn recent years, zebrafish (Danio rerio) have become a valuable model organism in diverse research fields, i...
The impact of ferroptosis and ferroptosis-related non-coding RNAs on breast cancer progression
1 IntroductionBreast cancer (BC) represents a significant global health threat to women (Makhoul et al., 2018). Recent can...
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