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Effect of heparanase inhibitor on tissue factor overexpression in platelets and endothelial cells induced by anti‐β2‐GPI antibodies: Reply to comment from Mackman et al.
Effect of heparanase inhibitor on tissue factor overexpression in platelets and endothelial cells induced by anti‐β2‐GPI antibodies: Reply to comment from Mackman et al.
Volume 20, Issue 1 p. 261-262 LETTER TO THE EDITOR Antonella Capozzi, Antonella Capoz...
The COVID‐19 vaccine ChAdOx1‐S is not contaminated with sulfated glycosaminoglycans
The COVID‐19 vaccine ChAdOx1‐S is not contaminated with sulfated glycosaminoglycans
Abstract -
What the neighbors say
What the neighbors say
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Thrombomodulin (THBD) gene variants and thrombotic risk in a population‐based cohort study
Thrombomodulin (THBD) gene variants and thrombotic risk in a population‐based cohort study
Abstract Background The protein C anticoagulant system plays a key role in maintaining the hemostatic balance. Although se...
Effect of heparanase inhibitor on tissue factor overexpression in platelets and endothelial cells induced by anti‐β2‐GPI antibodies: Comment from Mackman et al.
Effect of heparanase inhibitor on tissue factor overexpression in platelets and endothelial cells induced by anti‐β2‐GPI antibodies: Comment from Mackman et al.
Corresponding Author Nigel Mackman UNC Blood Research Cent...
Hemostasis in tweeters
Hemostasis in tweeters
Volume 20, Issue 1 p. 272-273 LETTER TO THE EDITOR Jecko Thachil, Corresponding Autho...
Identification of the histidine‐rich glycoprotein domains responsible for contact pathway inhibition
Identification of the histidine‐rich glycoprotein domains responsible for contact pathway inhibition
SUMMARY Background Previously, we showed that histidine-rich glycoprotein (HRG) binds factor (F) XIIa with high affinity, ...
Changes and challenges in the new year
Changes and challenges in the new year
As we begin our fourth year as editors-in-chief of JTH, we are delighted to welcome these accomplished investigators as as...
Galectin‐9 activates platelet ITAM receptors Glycoprotein VI and C‐type Lectin‐Like Receptor‐2
Galectin‐9 activates platelet ITAM receptors Glycoprotein VI and C‐type Lectin‐Like Receptor‐2
Summary Background Platelets are multifunctional cellular mediators in many physiological and pathophysiological processes...
The functional role of the autolysis loop in the regulation of Factor X upon hemostatic response
The functional role of the autolysis loop in the regulation of Factor X upon hemostatic response
Abstract Background The regulation of Factor X (FX) is critical to maintain the balance between blood coagulation and flui...
Targeted proteomics for evaluating risk of venous thrombosis following traumatic lower‐leg injury or knee arthroscopy
Targeted proteomics for evaluating risk of venous thrombosis following traumatic lower‐leg injury or knee arthroscopy
Abstract Introduction Patients with lower-leg cast immobilization and patients undergoing knee arthroscopy have an increas...
The plasminogen receptor Plg‐RKT regulates adipose function and metabolic homeostasis
The plasminogen receptor Plg‐RKT regulates adipose function and metabolic homeostasis
Abstract Background Plg-RKT, a unique transmembrane plasminogen receptor, enhances the activation of plasminogen to plasmi...
Stoichiometric analysis reveals a unique phosphatidylserine binding site in coagulation factor X
Stoichiometric analysis reveals a unique phosphatidylserine binding site in coagulation factor X
ABSTRACT Background Cellular trauma or activation exposes phosphatidylserine (PS) and the substantially more abundant phos...
Breaking the fibrinolytic speed limit with microwheel co‐delivery of tissue plasminogen activator and plasminogen
Breaking the fibrinolytic speed limit with microwheel co‐delivery of tissue plasminogen activator and plasminogen
Abstract Background To reestablish blood flow in vessels occluded by clots, tissue plasminogen activator (tPA) can be used...
The risk of Venous ThromboEmbolism (VTE) in Early Pregnancy Loss: Review of the Literature and Current Guidelines and the Need for Guidance Communication from the SSC on Women’s Health Issues for Thrombosis and Haemostasis
The risk of Venous ThromboEmbolism (VTE) in Early Pregnancy Loss: Review of the Literature and Current Guidelines and the Need for Guidance Communication from the SSC on Women’s Health Issues for Thrombosis and Haemostasis
Abstract Background Thromboembolic disease is one of the major causes of mortality and morbidity in pregnancy and the puer...
Removal of single‐site N‐linked glycans on factor VIII alters binding of domain‐specific monoclonal antibodies
Removal of single‐site N‐linked glycans on factor VIII alters binding of domain‐specific monoclonal antibodies
Summary Background A portion of individuals with hemophilia A develop neutralizing antibodies called inhibitors to glycopr...
Incidence of bleeding and thromboembolism and impact on overall survival in adult patients with hemophagocytic lymphohistiocytosis: A 20‐year provincial retrospective cohort study
Incidence of bleeding and thromboembolism and impact on overall survival in adult patients with hemophagocytic lymphohistiocytosis: A 20‐year provincial retrospective cohort study
Abstract Background Hemophagocytic lymphohistiocytosis (HLH) is a rare syndrome characterized by uncontrolled immune activ...
Anticoagulant treatment for Upper Extremity Deep Vein thrombosis: a systematic review and meta‐analysis
Anticoagulant treatment for Upper Extremity Deep Vein thrombosis: a systematic review and meta‐analysis
Summary Background Data on anticoagulant treatment for upper extremity deep vein thrombosis (UEDVT) are largely derived fr...
A peptide from the staphylococcal protein Efb binds P‐selectin and inhibits the interaction of platelets with leukocytes
A peptide from the staphylococcal protein Efb binds P‐selectin and inhibits the interaction of platelets with leukocytes
ABSTRACT Aims P-selectin is a key surface adhesion molecule for the interaction of platelets with leukocytes. We have show...
Factor VIII as a potential player in cancer pathophysiology
Factor VIII as a potential player in cancer pathophysiology
ABSTRACT Background “Trousseau’s Sign” was the first demonstration of a close relationship between ca...
Factor V east Texas variant causes bleeding in a three‐generation family
Factor V east Texas variant causes bleeding in a three‐generation family
Abstract Background The factor V east Texas bleeding disorder (FVETBD) is caused by increased plasma tissue factor pathway...
An update on the global use of risk assessment models and thromboprophylaxis in hospitalized patients with medical illnesses from the World Thrombosis Day steering committee: systematic review and meta‐analysis
An update on the global use of risk assessment models and thromboprophylaxis in hospitalized patients with medical illnesses from the World Thrombosis Day steering committee: systematic review and meta‐analysis
Abstract Introduction Venous thromboembolism (VTE) is a leading cause of cardiovascular morbidity and mortality. The major...
A rapid, sensitive and specific assay to measure TF activity based on chromogenic determination of thrombin generation
A rapid, sensitive and specific assay to measure TF activity based on chromogenic determination of thrombin generation
Abstract Background The majority of TF activity assays are based on measurement of FX activation by TF in the presence of ...
Current practices of standardized risk assessment for venous thromboembolism: results from a global survey from the World Thrombosis Day steering committee
Current practices of standardized risk assessment for venous thromboembolism: results from a global survey from the World Thrombosis Day steering committee
Abstract The global annual incidence of venous thromboembolism (VTE) is estimated to be 0.75–2.69 per 1,000 populat...
Extended anticoagulation treatment for cancer‐associated thrombosis ‐ rates of recurrence and bleeding beyond 6 months: A systematic review
Extended anticoagulation treatment for cancer‐associated thrombosis ‐ rates of recurrence and bleeding beyond 6 months: A systematic review
Abstract Background Patients with cancer-associated venous thromboembolism (VTE) are recommended to receive treatment with...
Osteoprotegerin modulates platelet adhesion to von Willebrand factor during release from endothelial cells
Osteoprotegerin modulates platelet adhesion to von Willebrand factor during release from endothelial cells
Abstract Background Platelet-binding Von Willebrand Factor (VWF) strings assemble upon stimulated secretion from endotheli...
Thrombosis and Thrombocytopenia after HPV Vaccination
Thrombosis and Thrombocytopenia after HPV Vaccination
ABSTRACT Background Vaccine-induced immune thrombotic thrombocytopenia (VITT) has so far only been reported after adenovir...
Previously Undiagnosed Cancer in Patients with Arterial Thrombotic Events – A Population‐based Cohort Study
Previously Undiagnosed Cancer in Patients with Arterial Thrombotic Events – A Population‐based Cohort Study
Summary Background Emerging data suggest increased arterial thrombosis risk in the months preceding a cancer diagnosis. Ob...
Dose tapering to withdrawal stage and long‐term efficacy and safety of hetrombopag for the treatment of immune thrombocytopenia: results from an open‐label extension study
Dose tapering to withdrawal stage and long‐term efficacy and safety of hetrombopag for the treatment of immune thrombocytopenia: results from an open‐label extension study
Abstract Background The efficacy of hetrombopag in Chinese patients with immune thrombocytopenia (ITP) has been demonstrat...
Removing plasmin from the equation – Something to chew on…
Removing plasmin from the equation – Something to chew on…
Corresponding Author Aberdeen Cardiovascular & Diabetes Centre, Institute o...
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