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Status of alternative angiogenic pathways in glioblastoma resected under and after bevacizumab treatment
Status of alternative angiogenic pathways in glioblastoma resected under and after bevacizumab treatment
Glioblastoma multiforme (GBM) acquires resistance to bevacizumab (Bev) treatment. Bev affects angiogenic factors other tha...
Comprehensive genomic analysis reveals clonal origin and subtype-specific evolution in a case of sporadic multiple meningiomas
Comprehensive genomic analysis reveals clonal origin and subtype-specific evolution in a case of sporadic multiple meningiomas
Meningioma is the most common primary intracranial tumor in adults, with up to 10% manifesting as multiple tumors. Data on...
MAPK pathway alterations in polymorphous low-grade neuroepithelial tumor of the young: diagnostic considerations
MAPK pathway alterations in polymorphous low-grade neuroepithelial tumor of the young: diagnostic considerations
Polymorphous low-grade neuroepithelial tumor of the young (PLNTY) is a recently recognised tumor type with indolent behavi...
Comparative analyses of immune cells and alpha-smooth muscle actin-positive cells under the immunological microenvironment between with and without dense fibrosis in primary central nervous system lymphoma
Comparative analyses of immune cells and alpha-smooth muscle actin-positive cells under the immunological microenvironment between with and without dense fibrosis in primary central nervous system lymphoma
Histopathologic examinations of primary central nervous system lymphoma (PCNSL) reveal concentric accumulation of lymphocy...
Double-hit primary central nervous system lymphoma with histogenetically proven bone marrow infiltration: a case report and a review of the literature
Double-hit primary central nervous system lymphoma with histogenetically proven bone marrow infiltration: a case report and a review of the literature
Double-hit lymphoma (DHL) formerly referred to high-grade B-cell lymphoma with concurrent MYC and BCL2 or BCL6 rearrangeme...
Novel case of ependymoma-like tumor with mesenchymal differentiation harboring fusion in an adult
Novel case of ependymoma-like tumor with mesenchymal differentiation harboring fusion in an adult
High-grade supratentorial tumors harboring ZFTA::NCOA1/2 fusion in infants presenting with mixed histology of embryonal-ap...
Astroblastoma with in an elderly patient: A case report and review of the literature
Astroblastoma with in an elderly patient: A case report and review of the literature
Louis DN, Perry A, Wesseling P et al (2021) The 2021 WHO classification of tumors of the central nervous system: a summary...
Combination treatment with histone deacetylase and carbonic anhydrase 9 inhibitors shows therapeutic potential in experimental diffuse intrinsic pontine glioma
Combination treatment with histone deacetylase and carbonic anhydrase 9 inhibitors shows therapeutic potential in experimental diffuse intrinsic pontine glioma
Diffuse intrinsic pontine glioma (DIPG) remains a significant therapeutic challenge due to the lack of effective and safe ...
Tectal glioma: clinical, radiological, and pathological features, and the importance of molecular analysis
Tectal glioma: clinical, radiological, and pathological features, and the importance of molecular analysis
Tectal glioma (TG) is a rare lower grade glioma (LrGG) that occurs in the tectum, mainly affecting children. TG shares pat...
Visualizing the endothelial glycocalyx in human glioma vasculature
Visualizing the endothelial glycocalyx in human glioma vasculature
Gliomas are the most common primary brain tumors in adults. However, glioblastoma is especially difficult to treat despite...
CLINICAL utility of assessing status in recurrent astrocytomas
CLINICAL utility of assessing status in recurrent astrocytomas
IDH-mutant astrocytomas exhibit a more indolent natural history and better prognosis compared to their IDH-wild type count...
Discordant lymphoma characterized by the coexistence of diffuse large B-cell lymphoma in the brain and mantle cell lymphoma in the colon, rectum, and bone marrow
Discordant lymphoma characterized by the coexistence of diffuse large B-cell lymphoma in the brain and mantle cell lymphoma in the colon, rectum, and bone marrow
We describe a rare case of discordant lymphoma characterized by the coexistence of diffuse large B-cell lymphoma (DLBCL) i...
Analysis of clinical, histological, and genomic information of molecular glioblastoma in a Japanese glioma cohort
Analysis of clinical, histological, and genomic information of molecular glioblastoma in a Japanese glioma cohort
In the 2021 WHO Central Nervous System tumor classification, the “Glioblastoma, IDH-wildtype” diagnosis change...
The function of chaperones in the radioresistance of glioblastoma: a new insight into the current knowledge
The function of chaperones in the radioresistance of glioblastoma: a new insight into the current knowledge
Radiotherapy remains a cornerstone of brain tumor treatment; however, its effectiveness is frequently undermined by the de...
Rapidly progressive scalp and lung metastases with fatal pneumothorax in glioblastoma, IDH-wildtype, with and amplifications: a case report of clinical course and postmortem autopsy, including genetic analysis
Rapidly progressive scalp and lung metastases with fatal pneumothorax in glioblastoma, IDH-wildtype, with and amplifications: a case report of clinical course and postmortem autopsy, including genetic analysis
We report a rare case of extracranial metastases of a glioblastoma, IDH-wildtype, in a 77-year-old man who initially prese...
Intraspinal rearranged tumor with nerve differentiation
Intraspinal rearranged tumor with nerve differentiation
The ASPSCR1::TFE3 rearrangement has been described in alveolar soft part sarcoma, MiT family translocation renal cell carc...
Triple sellar collision lesion: a unique case of pituitary adenoma, Rathke cleft cyst, and xanthogranuloma—case report and systematic review of the literature
Triple sellar collision lesion: a unique case of pituitary adenoma, Rathke cleft cyst, and xanthogranuloma—case report and systematic review of the literature
The coexistence of three lesions in the sellar region is exceedingly rare. Only two cases with three histopathologically d...
FISH analysis reveals CDKN2A and IFNA14 co-deletion is heterogeneous and is a prominent feature of glioblastoma
FISH analysis reveals CDKN2A and IFNA14 co-deletion is heterogeneous and is a prominent feature of glioblastoma
Deletion of CDKN2A occurs in 50% of glioblastomas (GBM), and IFNA locus deletion in 25%. These genes reside closely on chr...
A rare case of primary central nervous system histiocytic sarcoma harboring a novel ARHGAP45::BRAF fusion: a case report and literature review
A rare case of primary central nervous system histiocytic sarcoma harboring a novel ARHGAP45::BRAF fusion: a case report and literature review
Patients with histiocytic sarcoma occurring in the central nervous system (CNS) are rare and have a very poor prognosis. T...
Touch imprint cytology is useful for the intraoperative pathological diagnosis of PitNETs’ surgical margins
Touch imprint cytology is useful for the intraoperative pathological diagnosis of PitNETs’ surgical margins
Touch imprint cytology (TIC) and frozen section (FS) procedures are essential for intraoperative pathological diagnosis (I...
Intraventricular central neurocytoma molecularly defined as extraventricular neurocytoma: a case representing the discrepancy between clinicopathological and molecular classifications
Intraventricular central neurocytoma molecularly defined as extraventricular neurocytoma: a case representing the discrepancy between clinicopathological and molecular classifications
Central neurocytoma (CN) is classically defined by its intraventricular location, neuronal/neurocytic differentiation, and...
Integrated analysis of multiple methods reveals characteristics of the immune microenvironment in medulloblastoma
Integrated analysis of multiple methods reveals characteristics of the immune microenvironment in medulloblastoma
To explore the characteristics of the immune microenvironment (IME) of medulloblastoma (MB) by four methods: flow cytometr...
Diffuse paediatric-type high-grade glioma, H3-wildtype and IDH-wildtype: case series of a new entity
Diffuse paediatric-type high-grade glioma, H3-wildtype and IDH-wildtype: case series of a new entity
Diffuse paediatric-type high-grade glioma, H3-wildtype and IDH-wildtype (pHGG) is a rare and aggressive brain tumor charac...
Spontaneous malignant transformation of trigeminal schwannoma: consideration of responsible gene alterations for tumorigenesis—a case report
Spontaneous malignant transformation of trigeminal schwannoma: consideration of responsible gene alterations for tumorigenesis—a case report
Malignant peripheral nerve sheath tumors (MPNSTs) arising from the trigeminal nerves are extremely rare (only 45 cases, in...
A clinicopathological analysis of supratentorial ependymoma, ZFTA fusion-positive: utility of immunohistochemical detection of CDKN2A alterations and characteristics of the immune microenvironment
A clinicopathological analysis of supratentorial ependymoma, ZFTA fusion-positive: utility of immunohistochemical detection of CDKN2A alterations and characteristics of the immune microenvironment
EPN-ZFTA is a rare brain tumor where prognostic factors remain unclear and no effective immunotherapy or chemotherapy is c...
α-SMA positive vascular mural cells suppress cyst formation in hemangioblastoma
α-SMA positive vascular mural cells suppress cyst formation in hemangioblastoma
Approximately 60% of hemangioblastomas (HBs) have peritumoral cysts adjacent to the tumor, which can cause neurological de...
IDH wild-type lower-grade gliomas with glioblastoma molecular features: a systematic review and meta-analysis
IDH wild-type lower-grade gliomas with glioblastoma molecular features: a systematic review and meta-analysis
The WHO 2021 classification defines IDH wild type (IDHw) histologically lower-grade glioma (hLGG) as molecular glioblastom...
Lynch syndrome-associated chordoma with high tumor mutational burden and significant response to immune checkpoint inhibitors
Lynch syndrome-associated chordoma with high tumor mutational burden and significant response to immune checkpoint inhibitors
Chordoma is a rare malignant bone tumor arising from notochordal tissue. Conventional treatments, such as radical resectio...
Immunohistochemical and ultrastructural review of six cases previously diagnosed as null cell PitNETs
Immunohistochemical and ultrastructural review of six cases previously diagnosed as null cell PitNETs
Pituitary neuroendocrine tumors (PitNETs) lacking lineage affiliation are termed “null cell” PitNETs (NCTs). N...
Spatial metabolic heterogeneity of oligodendrogliomas at single-cell resolution
Spatial metabolic heterogeneity of oligodendrogliomas at single-cell resolution
Oligodendrogliomas are a type of rare and incurable gliomas whose metabolic profiles have yet to be fully examined. The pr...
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