SCI Abstract

Statins mediate anti- and pro-tumourigenic functions by remodelling the tumour microenvironment

Cell surface marker and intracellular SPC expression was analysed by flow cytome...

Disease Models & Mechanisms

MEK-inhibitor-mediated rescue of skeletal myopathy caused by activating Hras mutation in a Costello syndrome mouse model

The Ras pathway is a well-studied signal transduction pathway i...

Disease Models & Mechanisms

First person – Jun-yi Zhu and Xiaohu Huang

First Person is a series of interviews with the first authors o...

Disease Models & Mechanisms

Pharmacological or genetic inhibition of hypoxia signaling attenuates oncogenic RAS -induced cancer phenotypes

In this study, we generated a new KRASG12V leukemia model in Drosophila by expre...

Disease Models & Mechanisms

Biology, technology and a bit of serendipity: an interview with Shiva Malek

...

Disease Models & Mechanisms

Selective disruption of trigeminal sensory neurogenesis and differentiation in a mouse model of 22q11.2 deletion syndrome

E9.5 and E10.5 embryos were immersion fixed and prepared for cryosectioning and ...

Disease Models & Mechanisms

Tissue architecture delineates field cancerization in BRAF V600E -induced tumor development

The cell of origin in differentiated thyroid cancer – the folli...

Disease Models & Mechanisms

First person – Elin Schoultz and Ellen Johansson

First Person is a series of interviews with the first authors o...

Disease Models & Mechanisms