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Excess Serum Interleukin‐18 Distinguishes Patients With Pathogenic Mutations in PSTPIP1
Excess Serum Interleukin‐18 Distinguishes Patients With Pathogenic Mutations in PSTPIP1
Objective Dominantly inherited PSTPIP1 mutations cause a spectrum of autoinflammatory manifestations epitomized by PAPA sy...
Mepolizumab for Eosinophilic Granulomatosis With Polyangiitis: A European Multicenter Observational Study
Mepolizumab for Eosinophilic Granulomatosis With Polyangiitis: A European Multicenter Observational Study
Objective Mepolizumab proved to be an efficacious treatment for eosinophilic granulomatosis with polyangiitis (EGPA) at a ...
Progression of Knee Osteoarthritis With Use of Intraarticular Glucocorticoids Versus Hyaluronic Acid
Progression of Knee Osteoarthritis With Use of Intraarticular Glucocorticoids Versus Hyaluronic Acid
Objective To determine whether intraarticular glucocorticoid (GC) injections are associated with increased knee osteoarthr...
Association of Structural Entheseal Lesions With an Increased Risk of Progression From Psoriasis to Psoriatic Arthritis
Association of Structural Entheseal Lesions With an Increased Risk of Progression From Psoriasis to Psoriatic Arthritis
Objective To test whether the presence of structural entheseal lesions in psoriasis patients influences the risk of progre...
Activation of Hypothalamic AMP‐Activated Protein Kinase Ameliorates Metabolic Complications of Experimental Arthritis
Activation of Hypothalamic AMP‐Activated Protein Kinase Ameliorates Metabolic Complications of Experimental Arthritis
Objective To investigate whether thermogenesis and the hypothalamus may be involved in the physiopathology of experimental...
Clinical Images: Diffuse systemic sclerosis, skin bleaching, and telangiectasia
Clinical Images: Diffuse systemic sclerosis, skin bleaching, and telangiectasia
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Evaluation of Immune Response and Disease Status in Systemic Lupus Erythematosus Patients Following SARS–CoV‐2 Vaccination
Evaluation of Immune Response and Disease Status in Systemic Lupus Erythematosus Patients Following SARS–CoV‐2 Vaccination
Objective To evaluate seroreactivity and disease flares after COVID-19 vaccination in a multiethnic/multiracial cohort of ...
Phase III/IV, Randomized, Fifty‐Two–Week Study of the Efficacy and Safety of Belimumab in Patients of Black African Ancestry With Systemic Lupus Erythematosus
Phase III/IV, Randomized, Fifty‐Two–Week Study of the Efficacy and Safety of Belimumab in Patients of Black African Ancestry With Systemic Lupus Erythematosus
Objective Enrollment of patients of Black African ancestry with systemic lupus erythematosus (SLE) in phase II and phase I...
Activated Peripheral Blood B Cells in Rheumatoid Arthritis and Their Relationship to Anti–Tumor Necrosis Factor Treatment and Response: A Randomized Clinical Trial of the Effects of Anti–Tumor Necrosis Factor on B Cells
Activated Peripheral Blood B Cells in Rheumatoid Arthritis and Their Relationship to Anti–Tumor Necrosis Factor Treatment and Response: A Randomized Clinical Trial of the Effects of Anti–Tumor Necrosis Factor on B Cells
Objective B cells can become activated in germinal center (GC) reactions in secondary lymphoid tissue and in ectopic GCs i...
Fanning the flames of autoimmunity: the microbiome in rheumatic disease
Fanning the flames of autoimmunity: the microbiome in rheumatic disease
This article has been accepted for publication and undergone full peer review but has not been through the copye...
Conflicting reports of anti‐NT5C1a autoantibodies in juvenile myositis: Comment on the article by Rietveld et al
Conflicting reports of anti‐NT5C1a autoantibodies in juvenile myositis: Comment on the article by Rietveld et al
This article has been accepted for publication and undergone full peer review but has not been through the copye...
Rituximab impairs B‐cell response but not T‐cell response to COVID‐19 vaccine in auto‐immune diseases
Rituximab impairs B‐cell response but not T‐cell response to COVID‐19 vaccine in auto‐immune diseases
Objective Antibody response to COVID-19 vaccine has been shown to be diminished in rituximab (RTX)-treated patients. We co...
Interleukin‐1‐β‐Activated Microvascular Endothelial Cells Promote DC‐SIGN+ Alternative Macrophages Associated with Skin Fibrosis in Systemic Sclerosis
Interleukin‐1‐β‐Activated Microvascular Endothelial Cells Promote DC‐SIGN+ Alternative Macrophages Associated with Skin Fibrosis in Systemic Sclerosis
Objective To characterize the role of interleukin (IL)-1β and skin microvascular endothelial cells (MECs) in the gen...
Induction of Interferon‐γ and Tissue Inflammation by Overexpression of Eosinophil Cationic Protein in T Cells and Exosomes
Induction of Interferon‐γ and Tissue Inflammation by Overexpression of Eosinophil Cationic Protein in T Cells and Exosomes
Objective T cells play a critical role in the pathogenesis of systemic lupus erythematosus (SLE). Serum-derived exosomes a...
Issue Information ‐ General Info
Issue Information ‐ General Info
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Impact of cytokine inhibitor therapy on the prevalence, seroconversion rate and longevity of the humoral immune response against SARS‐CoV‐2 in an unvaccinated cohort
Impact of cytokine inhibitor therapy on the prevalence, seroconversion rate and longevity of the humoral immune response against SARS‐CoV‐2 in an unvaccinated cohort
Objective: To investigate the impact of biological DMARD treatment on the prevalence, seroconversion rate and longevity of...
Platelet Phagocytosis via P‐selectin Glycoprotein Ligand 1 and Accumulation of Microparticles in Systemic Sclerosis
Platelet Phagocytosis via P‐selectin Glycoprotein Ligand 1 and Accumulation of Microparticles in Systemic Sclerosis
Objective It is unclear why activated platelets and platelet-derived microparticles (MPs) accumulate in the blood of patie...
Incidence of Psoriatic Arthritis Among Patients Receiving Biologic Treatments for Psoriasis: A Nested Case–Control Study
Incidence of Psoriatic Arthritis Among Patients Receiving Biologic Treatments for Psoriasis: A Nested Case–Control Study
Objective To investigate the effect of biologic treatments for psoriasis on the incidence of psoriatic arthritis (PsA). Me...
Clinical Images: The appearance of scurvy on magnetic resonance imaging
Clinical Images: The appearance of scurvy on magnetic resonance imaging
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Clinical Images: Two distinct MRI findings in polyarteritis nodosa
Clinical Images: Two distinct MRI findings in polyarteritis nodosa
This article has been accepted for publication and undergone full peer review but has not been through the copye...
Reply to the Letter to the Editor by Kimura et al “Response to Editorial Accompanying STOP‐JIA Articles by Ruperto, et al”
Reply to the Letter to the Editor by Kimura et al “Response to Editorial Accompanying STOP‐JIA Articles by Ruperto, et al”
This article has been accepted for publication and undergone full peer review but has not been through the copye...
Response to Editorial Accompanying STOP‐JIA Articles by Ruperto, et al.
Response to Editorial Accompanying STOP‐JIA Articles by Ruperto, et al.
Accepted Articles Letter to the Editor Yukiko Kimura MD, Corresponding Author ...
Highly multiplexed imaging mass cytometry identifies similarities between antisynthetase syndrome and dermatomyositis skin lesions
Highly multiplexed imaging mass cytometry identifies similarities between antisynthetase syndrome and dermatomyositis skin lesions
Objective Antisynthetase syndrome (AS) and Dermatomyositis (DM) are autoimmune disorders that overlap clinically. Given th...
Sjögren disease, not Sjögren's: comment on the article by Baer and Hammitt
Sjögren disease, not Sjögren's: comment on the article by Baer and Hammitt
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B‐cell reconstitution is strongly associated with COVID‐19 vaccine responsiveness in rheumatic disease patients treated with rituximab
B‐cell reconstitution is strongly associated with COVID‐19 vaccine responsiveness in rheumatic disease patients treated with rituximab
Objective We assessed the association of detectable antibody response to COVID-19 vaccination with factors including B-cel...
CD163+ M2 macrophages promote fibrosis in IgG4‐related disease via TLR7/IRAK4/NF‐κB signaling
CD163+ M2 macrophages promote fibrosis in IgG4‐related disease via TLR7/IRAK4/NF‐κB signaling
Objective IgG4-related disease (IgG4-RD) is a fibro-inflammatory condition that can affect multiple organs. We previously ...
Effect of Clonally Expanded PD‐1highCXCR5–CD4+ Peripheral T Helper Cells on B Cell Differentiation in the Joints of Patients With Antinuclear Antibody–Positive Juvenile Idiopathic Arthritis
Effect of Clonally Expanded PD‐1highCXCR5–CD4+ Peripheral T Helper Cells on B Cell Differentiation in the Joints of Patients With Antinuclear Antibody–Positive Juvenile Idiopathic Arthritis
Objective Antinuclear antibody (ANA)–positive juvenile idiopathic arthritis (JIA) is characterized by synovial B ce...
Role of Ciliary Protein Intraflagellar Transport Protein 88 in the Regulation of Cartilage Thickness and Osteoarthritis Development in Mice
Role of Ciliary Protein Intraflagellar Transport Protein 88 in the Regulation of Cartilage Thickness and Osteoarthritis Development in Mice
Objective Mechanical and biologic cues drive cellular signaling in cartilage development, health, and disease. Primary cil...
Intensive serum urate lowering with oral urate‐lowering therapy for erosive gout: A randomized double‐blind controlled trial
Intensive serum urate lowering with oral urate‐lowering therapy for erosive gout: A randomized double‐blind controlled trial
Objective To determine whether intensive serum urate lowering results in improved bone erosion scores in erosive gout. Met...
Diastolic Dysfunction in Systemic Sclerosis: Risk Factors and Impact on Mortality
Diastolic Dysfunction in Systemic Sclerosis: Risk Factors and Impact on Mortality
Objective To determine the independent risk factors for diastolic dysfunction (DD) in patients with systemic sclerosis (SS...
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