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Positive feedback loop PU.1-IL9 in Th9 promotes rheumatoid arthritis development
Positive feedback loop PU.1-IL9 in Th9 promotes rheumatoid arthritis development
Materials and methodsPatients and normal volunteersThis study was approved by the Biomedical Ethics Committee of Anhui Med...
New WHO ACPA standard enables standardisation among anti-CCP2 assays, but not other ACPA assays using different antigens
New WHO ACPA standard enables standardisation among anti-CCP2 assays, but not other ACPA assays using different antigens
Antibodies to citrullinated protein/peptide (ACPA) are established biomarkers for diagnosis and classification of rheumato...
Acod1-mediated inhibition of aerobic glycolysis suppresses osteoclast differentiation and attenuates bone erosion in arthritis
Acod1-mediated inhibition of aerobic glycolysis suppresses osteoclast differentiation and attenuates bone erosion in arthritis
IntroductionRheumatoid arthritis (RA) is a chronic inflammatory joint disease that affects up to 1% of the population.1 Th...
SerpinA3N limits cartilage destruction in osteoarthritis by inhibiting macrophage-derived leucocyte elastase
SerpinA3N limits cartilage destruction in osteoarthritis by inhibiting macrophage-derived leucocyte elastase
AbstractObjectives Inflammatory mediators such as interleukin 6 (IL-6) are known to activate catabolic responses in chondr...
Rheumatoid arthritis patients harbour aberrant enteric bacteriophages with autoimmunity-provoking potential: a paired sibling study
Rheumatoid arthritis patients harbour aberrant enteric bacteriophages with autoimmunity-provoking potential: a paired sibling study
AbstractObjectives Viruses have been considered as important participants in the development of rheumatoid arthritis (RA)....
EULAR/PReS recommendations for the diagnosis and management of Stills disease, comprising systemic juvenile idiopathic arthritis and adult-onset Stills disease
EULAR/PReS recommendations for the diagnosis and management of Stills disease, comprising systemic juvenile idiopathic arthritis and adult-onset Stills disease
Overarching principles OP A: sJIA and AOSD are the same disease, that should be designated by the same unique name, Still...
Development of international consensus on a standardised image acquisition protocol for diagnostic evaluation of the sacroiliac joints by MRI: an ASAS-SPARTAN collaboration
Development of international consensus on a standardised image acquisition protocol for diagnostic evaluation of the sacroiliac joints by MRI: an ASAS-SPARTAN collaboration
IntroductionFor several decades, MRI has been used to investigate the early diagnosis of inflammatory sacroiliitis.1 2 How...
Clinical information on imaging referrals for suspected or known axial spondyloarthritis: recommendations from the Assessment of Spondyloarthritis International Society (ASAS)
Clinical information on imaging referrals for suspected or known axial spondyloarthritis: recommendations from the Assessment of Spondyloarthritis International Society (ASAS)
IntroductionImaging plays a pivotal role in the diagnosis and ongoing management of axial spondyloarthritis (axSpA), a con...
Early identification of rheumatoid arthritis: does it induce treatment-related cost savings?
Early identification of rheumatoid arthritis: does it induce treatment-related cost savings?
AbstractObjective Early diagnosis and treatment-start is key for rheumatoid arthritis (RA), but the economic effect of an ...
Paul Hunter Plotz (1937-2024): renaissance rheumatologist, human rights advocate and mensch
Paul Hunter Plotz (1937-2024): renaissance rheumatologist, human rights advocate and mensch
Paul Hunter Plotz, MD, a Scientist Emeritus in the National Institute of Arthritis and Musculoskeletal and Skin Diseases (...
Helicobacter pylori upregulates PAD4 expression via stabilising HIF-1{alpha} to exacerbate rheumatoid arthritis
Helicobacter pylori upregulates PAD4 expression via stabilising HIF-1{alpha} to exacerbate rheumatoid arthritis
WHAT IS ALREADY KNOWN ON THIS TOPICWHAT THIS STUDY ADDS H. pylori infection promotes synovial cell proliferation and infla...
New biologic (Ab-IPL-IL-17) for IL-17-mediated diseases: identification of the bioactive sequence (nIL-17) for IL-17A/F function
New biologic (Ab-IPL-IL-17) for IL-17-mediated diseases: identification of the bioactive sequence (nIL-17) for IL-17A/F function
IntroductionEvidence from basic research and clinical trials demonstrates that the interleukin (IL) 17 immune axis exerts ...
Annals of the Rheumatic Diseases collection on autoantibodies in the rheumatic diseases: new insights into pathogenesis and the development of novel biomarkers
Annals of the Rheumatic Diseases collection on autoantibodies in the rheumatic diseases: new insights into pathogenesis and the development of novel biomarkers
IntroductionAutoimmunity is central to the pathogenesis of many rheumatic diseases and has therefore been the focus of man...
The 2023 ACR/EULAR classification criteria for calcium pyrophosphate deposition disease
The 2023 ACR/EULAR classification criteria for calcium pyrophosphate deposition disease
IntroductionCalcium pyrophosphate deposition (CPPD) disease is a common symptomatic arthritis characterised by the deposit...
2023 ACR/EULAR antiphospholipid syndrome classification criteria
2023 ACR/EULAR antiphospholipid syndrome classification criteria
IntroductionAntiphospholipid syndrome (APS) is a systemic autoimmune disease characterised by arterial, venous, or microva...
Correspondence on 'Clinical course of coronavirus disease 2019 (COVID-19) in a series of 17 patients with systemic lupus erythematosus under long-term treatment with hydroxychloroquine
Correspondence on 'Clinical course of coronavirus disease 2019 (COVID-19) in a series of 17 patients with systemic lupus erythematosus under long-term treatment with hydroxychloroquine
Mathian et al described the clinical course and heterogeneity of COVID-19 in 17 systemic lupus erythematosus (SLE) patient...
Certolizumab pegol, abatacept, tocilizumab or active conventional treatment in early rheumatoid arthritis: 48-week clinical and radiographic results of the investigator-initiated randomised controlled NORD-STAR trial
Certolizumab pegol, abatacept, tocilizumab or active conventional treatment in early rheumatoid arthritis: 48-week clinical and radiographic results of the investigator-initiated randomised controlled NORD-STAR trial
WHAT IS ALREADY KNOWN ON THIS TOPICWHAT THIS STUDY ADDSFor the first time, three biologics with different modes of action,...
Three-month tapering and discontinuation of long- term, low-dose glucocorticoids in senior patients with rheumatoid arthritis is feasible and safe: placebo-controlled double blind tapering after the GLORIA trial
Three-month tapering and discontinuation of long- term, low-dose glucocorticoids in senior patients with rheumatoid arthritis is feasible and safe: placebo-controlled double blind tapering after the GLORIA trial
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Cleara...
Cost-utility analysis of tapering strategies of biologicals in rheumatoid arthritis patients in the Netherlands
Cost-utility analysis of tapering strategies of biologicals in rheumatoid arthritis patients in the Netherlands
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SGLT2 inhibitors alleviated podocyte damage in lupus nephritis by decreasing inflammation and enhancing autophagy
SGLT2 inhibitors alleviated podocyte damage in lupus nephritis by decreasing inflammation and enhancing autophagy
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Cleara...
Longitudinal gut microbiome analyses and blooms of pathogenic strains during lupus disease flares
Longitudinal gut microbiome analyses and blooms of pathogenic strains during lupus disease flares
ResultsGut dysbiosis is pronounced in patients with high disease activityTo study the gut microbial communities in sequent...
Single-cell transcriptome analysis profiles cellular and molecular alterations in submandibular gland and blood in IgG4-related disease
Single-cell transcriptome analysis profiles cellular and molecular alterations in submandibular gland and blood in IgG4-related disease
AbstractObjectives The aim of this study is to profile the transcriptional landscapes of affected tissues and peripheral b...
Incidence of primary large vessel vasculitis in Norfolk, UK from 2011 to 2020
Incidence of primary large vessel vasculitis in Norfolk, UK from 2011 to 2020
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Cleara...
Correspondence on 'Severity of COVID-19 and survival in patients with rheumatic and inflammatory diseases: data from the French RMD COVID-19 cohort of 694 patients
Correspondence on 'Severity of COVID-19 and survival in patients with rheumatic and inflammatory diseases: data from the French RMD COVID-19 cohort of 694 patients
The article of interest entitled ‘Severity of COVID-19 and survival in patients with rheumatic and inflammatory diseases: ...
Outcomes following SARS-CoV-2 infection in individuals with and without inflammatory rheumatic diseases: a Danish nationwide cohort study
Outcomes following SARS-CoV-2 infection in individuals with and without inflammatory rheumatic diseases: a Danish nationwide cohort study
IntroductionIn December 2019, SARS-CoV-2 was reported as the infectious agent leading to COVID-19.1 Globally, >762 mill...
Rare mimicker of sacroiliitis
Rare mimicker of sacroiliitis
A 62-year-old woman was referred for suspected sacroiliitis discovered incidentally on a CT scan performed for pre-transpl...
The 2022 EULAR/ACR points to consider at the early stages of diagnosis and management of suspected haemophagocytic lymphohistiocytosis/macrophage activation syndrome (HLH/MAS)
The 2022 EULAR/ACR points to consider at the early stages of diagnosis and management of suspected haemophagocytic lymphohistiocytosis/macrophage activation syndrome (HLH/MAS)
Systematic literature reviewBriefly, original research articles of any study design with diagnosis, treatment and monitori...
Correction: Combined therapy of prednisone and mTOR inhibitor sirolimus for treating retroperitoneal fibrosis
Correction: Combined therapy of prednisone and mTOR inhibitor sirolimus for treating retroperitoneal fibrosis
Gao H, Liu S, Mai Y, et al. Combined therapy of prednisone and mTOR inhibitor sirolimus for treating retroperitoneal fibro...
Correspondence to 'Bacterial citrullinated epitopes generated by Porphyromonas gingivalis infection--a missing link for ACPA production
Correspondence to 'Bacterial citrullinated epitopes generated by Porphyromonas gingivalis infection--a missing link for ACPA production
With great interest, we read the work by Jenning et al, which proposed a mechanism by which Porphyromonas gingivalis (P.g....
Methotrexate prolongs TNF inhibitor survival, but only in autoantibody-positive rheumatoid arthritis: a validation study
Methotrexate prolongs TNF inhibitor survival, but only in autoantibody-positive rheumatoid arthritis: a validation study
With great interest, we read the recently published report by Greenwood et al in which the benefits of coprescription of m...
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