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HUWE1 regulates mitophagy to protect dopaminergic neurons from 6-OHDA- and MPP⁺-induced neurotoxicity
HUWE1 regulates mitophagy to protect dopaminergic neurons from 6-OHDA- and MPP⁺-induced neurotoxicity
Parkinson’s disease (PD) is characterized by dopaminergic neuronal loss, often associated with mitochondrial dysfunc...
METTL7B-stabilized lncRNA-MIR22HG to drive p53-mediated neuronal apoptosis via the ubiquitinating JARID2 in cerebral ischemia/reperfusion injury
METTL7B-stabilized lncRNA-MIR22HG to drive p53-mediated neuronal apoptosis via the ubiquitinating JARID2 in cerebral ischemia/reperfusion injury
Ischemic stroke (IS) constitutes a leading driver of mortality and morbidity worldwide, with neuronal apoptosis representi...
EGR1/miR-4306/MAT2A axis aggravates pyroptosis and extracellular matrix degradation of nucleus pulposus cells in intervertebral disc degeneration
EGR1/miR-4306/MAT2A axis aggravates pyroptosis and extracellular matrix degradation of nucleus pulposus cells in intervertebral disc degeneration
Intervertebral disc degeneration (IVDD) acts as the prerequisite and pathological basis for a series of spinal degenerativ...
Mycotoxins, gut microbiota alterations and liver disease in animals: A scoping review
Mycotoxins, gut microbiota alterations and liver disease in animals: A scoping review
Mycotoxins are fungal secondary metabolites widely detected in up to eighty percent of frequently consumed foods, strongly...
Sublethal heat stress synergizes with the tumor microenvironment to drive recurrence of hepatocellular carcinoma after thermal ablation: mechanisms, molecular predictors, and targeted interventions
Sublethal heat stress synergizes with the tumor microenvironment to drive recurrence of hepatocellular carcinoma after thermal ablation: mechanisms, molecular predictors, and targeted interventions
Although thermal ablation has emerged as a minimally invasive and effective local treatment for hepatocellular carcinoma (...
Single-cell RNA-Seq reveals transcriptional heterogeneity in sepsis and down-regulation of SNHG5/miR-324-5p/CDK16 axis in T cells
Single-cell RNA-Seq reveals transcriptional heterogeneity in sepsis and down-regulation of SNHG5/miR-324-5p/CDK16 axis in T cells
T lymphopenia is a common phenomenon in the sepsis patients, closely related with secondary infection and patients death, ...
Inhibition of acalabrutinib metabolism by finerenone and its molecular docking studies
Inhibition of acalabrutinib metabolism by finerenone and its molecular docking studies
Acalabrutinib is a frontline agent for chronic lymphocytic leukemia (CLL). The objective of this experiment was to screen ...
Lipocalin 2: a double-edged sword in cellular ferroptosis
Lipocalin 2: a double-edged sword in cellular ferroptosis
Ferroptosis is a novel form of programmed cell death that is distinct from apoptosis, necrosis, and autophagy (macroautoph...
Overloaded mitochondrial stress drives reproductive damage in GC-1 mouse spermatogonia cells exposed to nickel nanoparticle
Overloaded mitochondrial stress drives reproductive damage in GC-1 mouse spermatogonia cells exposed to nickel nanoparticle
Nickel nanoparticles (Ni NPs) are widely used in industrial and commercial sectors, raising concerns about their potential...
Targeting ADAMTS1/HDAC6 alleviates TGF-β1/SMAD2-associated cardiac fibrosis in cardiac fibrosis post-myocardial infarction
Targeting ADAMTS1/HDAC6 alleviates TGF-β1/SMAD2-associated cardiac fibrosis in cardiac fibrosis post-myocardial infarction
A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1) is involved in the occurrence and development o...
Linc-ROR orchestrates autophagy suppression and marks gastric cancer via the miR-145-5p/CARMIL1 axis
Linc-ROR orchestrates autophagy suppression and marks gastric cancer via the miR-145-5p/CARMIL1 axis
Long non-coding RNAs (lncRNAs) have been considered the main regulators of cancer progression through their regulation of ...
Brain organoids in environmental neurotoxicology: applications, mechanisms, and future perspectives
Brain organoids in environmental neurotoxicology: applications, mechanisms, and future perspectives
The advent of human induced pluripotent stem cell (hiPSC)-derived brain organoids represents a significant advance in envi...
Toxicogenomic Characterization of Perfluorooctanoic Acid–Associated Bladder Carcinogenesis
Toxicogenomic Characterization of Perfluorooctanoic Acid–Associated Bladder Carcinogenesis
This study aims to bridge toxicological target prediction and bladder cancer transcriptomics by systematically identifying...
Chronic cadmium exposure promotes TRPM7-dependent acquisition of a myofibroblast-like phenotype in pancreatic stellate cells
Chronic cadmium exposure promotes TRPM7-dependent acquisition of a myofibroblast-like phenotype in pancreatic stellate cells
Cadmium (Cd) is a metallic pollutant which has been classified as a possible pancreatic carcinogen. Cd uses similar ion ch...
Lactate Dehydrogenase B delactylation promotes gastric cancer metastasis via enhancing glutathione-mediated resistance to ferroptosis
Lactate Dehydrogenase B delactylation promotes gastric cancer metastasis via enhancing glutathione-mediated resistance to ferroptosis
To elucidate the role of protein lactylation in gastric adenocarcinoma progression, focusing on lactate dehydrogenase B (L...
RNA mA modification is a driver and therapeutic target in gastric cancer
RNA mA modification is a driver and therapeutic target in gastric cancer
N6-methyladenosine (m6A), the most abundant modification in eukaryotic RNAs, plays a critical role in regulating RNA stabi...
GelMA hydrogel-loaded extracellular vesicles derived from keratinocytes promote skin microvasculature regeneration and wound healing in diabetic mice through activation of the PDGF-induced PI3K/AKT pathway
GelMA hydrogel-loaded extracellular vesicles derived from keratinocytes promote skin microvasculature regeneration and wound healing in diabetic mice through activation of the PDGF-induced PI3K/AKT pathway
This study explores how extracellular vesicles (EVs) derived from keratinocytes cultured in Gelatin Methacryloyl (GelMA) h...
From neurotoxicity to neuroprotection: Rethinking GABAR-targeting anesthetics
From neurotoxicity to neuroprotection: Rethinking GABAR-targeting anesthetics
The brain growth spurt (BGS) represents a pivotal window in neurodevelopment, defined by rapid neurogenesis, heightened sy...
The role of lncRNA in androgen metabolism and follicle growth arrest in polycystic ovary syndrome
The role of lncRNA in androgen metabolism and follicle growth arrest in polycystic ovary syndrome
Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism and follicular growth arrest. This study investigate...
Single-cell spatial proteomics of non-relapse small cell lung cancer identifies tumor microenvironment determinants of survival
Single-cell spatial proteomics of non-relapse small cell lung cancer identifies tumor microenvironment determinants of survival
Small cell lung cancer (SCLC) is characterized by high malignancy and early propensity for metastasis, and modest response...
ADT increases prostate cancer cell invasion via altering AR/SALL4/SOX2-OCT4 stem cell signaling
ADT increases prostate cancer cell invasion via altering AR/SALL4/SOX2-OCT4 stem cell signaling
Early studies indicated that the androgen-deprivation-therapy with antiandrogen Enzalutamide (Enz) could increase prostate...
Therapeutic targeting of PRSS3 to alleviate kidney damage in DKD
Therapeutic targeting of PRSS3 to alleviate kidney damage in DKD
As a primary contributor to end-stage renal disease, diabetic kidney disease (DKD) is characterized by metabolic and infla...
KMT2D/ZNF460-induced COL9A1-mediated extracellular matrix stiffness maintains the cancer stem cell pool to promote colorectal cancer progression
KMT2D/ZNF460-induced COL9A1-mediated extracellular matrix stiffness maintains the cancer stem cell pool to promote colorectal cancer progression
Collagen is a central component of the extracellular matrix (ECM) in tissues, and ECM can promote tumor cell immune evasio...
NGR-modified curcumin nanovesicles reverse immunotherapy resistance in triple-negative breast cancer via TLR9 and mTOR pathway modulation
NGR-modified curcumin nanovesicles reverse immunotherapy resistance in triple-negative breast cancer via TLR9 and mTOR pathway modulation
Curcumin (Cur), a natural bioactive compound extracted from Curcuma longa, has garnered extensive interest due to its modu...
YTHDF1 promotes p53 translation and induces ferroptosis during acute cerebral ischemia/reperfusion through mA-dependent binding
YTHDF1 promotes p53 translation and induces ferroptosis during acute cerebral ischemia/reperfusion through mA-dependent binding
The rapid escalation of oxidative and nitrosative stress during ischemia/reperfusion (I/R) triggers neuronal damage, leadi...
TEAD4-mediated upregulation of LPAR3 augments hepatic stellate cell activation in portal hypertension
TEAD4-mediated upregulation of LPAR3 augments hepatic stellate cell activation in portal hypertension
Based on bioinformatics insights, this study investigates the functions of lysophosphatidic acid receptor 3 (LPAR3) and TE...
cGAS-STING targeting offers novel therapeutic regimen in sepsis-associated organ dysfunction
cGAS-STING targeting offers novel therapeutic regimen in sepsis-associated organ dysfunction
Sepsis is clinically defined as a life-threatening syndrome characterized by dysregulated host responses to infection, cul...
Single-nucleus rna sequencing identifies universal camk1d upregulation and dysregulated c-ltmr subtypes as key drivers of paclitaxel-induced neuropathy
Single-nucleus rna sequencing identifies universal camk1d upregulation and dysregulated c-ltmr subtypes as key drivers of paclitaxel-induced neuropathy
Neuropathic pain triggered by chemotherapy poses a significant clinical challenge. Investigating cell type-specific altera...
Advances in hybrid hydrogel design for biomedical applications: innovations in drug delivery and tissue engineering for gynecological cancers
Advances in hybrid hydrogel design for biomedical applications: innovations in drug delivery and tissue engineering for gynecological cancers
Hybrid hydrogels have emerged as multifunctional biomaterials for targeted drug delivery and tissue engineering in gynecol...
Epi-nutrients for cancer prevention: Molecular mechanisms and emerging insights
Epi-nutrients for cancer prevention: Molecular mechanisms and emerging insights
The burgeoning field of epigenetics holds considerable potential in cancer prevention and management, as it targets mechan...
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