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How ligands tune the parathyroid hormone receptor’s grip on β-arrestin
How ligands tune the parathyroid hormone receptor’s grip on β-arrestin
β-arrestins are known modulators of GPCR signaling, but their precise interaction with class B GPCRs is poorly unders...
Rap1-mediated steric hindrance protects telomeres from MRX sensing
Rap1-mediated steric hindrance protects telomeres from MRX sensing
Telomere capping largely depends on telomere length. Abnormally short telomeres are prone to activate DNA damage checkpoin...
Author Correction: Structure, assembly and inhibition of the Toxoplasma gondii respiratory chain supercomplex
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Soma-to-germline miRNA inheritance through yolk promotes stress resilience in progeny
Soma-to-germline miRNA inheritance through yolk promotes stress resilience in progeny
At the onset of reproduction, oviparous animals synthesize large amounts of yolk in somatic tissues to provide lipids and ...
Dynamic regulation of H3K9 dimethylation drives mouse minor zygotic genome activation
Dynamic regulation of H3K9 dimethylation drives mouse minor zygotic genome activation
Minor zygotic genome activation (ZGA) is crucial for early development and totipotency acquisition; however, the regulator...
Yolk transports miRNAs to embryos and enhances progeny stress resilience
Yolk transports miRNAs to embryos and enhances progeny stress resilience
This study shows that yolk, a conserved vehicle for nutrient provisioning to developing eggs, also transports regulatory s...
Distinct repair outcomes from single and convergent replication fork collapse
Distinct repair outcomes from single and convergent replication fork collapse
Replication fork collapse at single-strand DNA breaks threatens genome stability but how such forks are repaired and resol...
How cohesin guides DNA repair via scanning and tethering
How cohesin guides DNA repair via scanning and tethering
A broken chromosome must find an identical DNA sequence among billions of bases packed into the nucleus. Although homologo...
Cryo-EM structure of the human THIK-1 K2P K+ channel reveals a lower Y gate regulated by lipids and anesthetics
Cryo-EM structure of the human THIK-1 K2P K+ channel reveals a lower Y gate regulated by lipids and anesthetics
THIK-1 (KCNK13) is a halothane-inhibited and anionic-lipid-activated two-pore domain (K2P) K+ channel implicated in microg...
A PAR6–aPKC–LGL structure reveals how LGL antagonizes aPKC
A PAR6–aPKC–LGL structure reveals how LGL antagonizes aPKC
The apical–basal polarity of epithelial cells depends on mutual antagonism between the apical aPKC and lateral LGL p...
Structures of a natural circularly permuted group II intron reveal mechanisms of branching and backsplicing
Structures of a natural circularly permuted group II intron reveal mechanisms of branching and backsplicing
Circularly permuted (CP) group II introns, identified in various bacteria phyla, swap domains D5 and D6 near the 5′ ...
Human polymerase θ helicase positions DNA microhomologies for double-strand break repair
Human polymerase θ helicase positions DNA microhomologies for double-strand break repair
DNA double-strand breaks occur daily in all human cells and must be repaired with high fidelity to minimize genomic instab...
A chromatin mesh model for compaction of chromatin by PRC1 in condensates
A chromatin mesh model for compaction of chromatin by PRC1 in condensates
The structure of chromatin bound by Polycomb repressive complex 1 (PRC1) and how it contributes to transcription repressio...
Guidelines for minimal reporting requirements, design and interpretation of experiments involving the use of eukaryotic dual gene expression reporters (MINDR)
Guidelines for minimal reporting requirements, design and interpretation of experiments involving the use of eukaryotic dual gene expression reporters (MINDR)
Dual reporters encoding two distinct proteins within the same mRNA have had a crucial role in identifying and characterizi...
CTCF-mediated 3D chromatin sets up the gene expression program in the male germline
CTCF-mediated 3D chromatin sets up the gene expression program in the male germline
Spermatogenesis is a unidirectional differentiation process that generates haploid sperm, but how the gene expression prog...
Structural insights into the iron nitrogenase complex
Structural insights into the iron nitrogenase complex
Nitrogenases are best known for catalyzing the reduction of dinitrogen to ammonia at a complex metallic cofactor. Recently...
Structural organization of the retriever–CCC endosomal recycling complex
Structural organization of the retriever–CCC endosomal recycling complex
The recycling of membrane proteins from endosomes to the cell surface is vital for cell signaling and survival. Retriever,...
Rational optimization of a transcription factor activation domain inhibitor
Rational optimization of a transcription factor activation domain inhibitor
Transcription factors are among the most attractive therapeutic targets but are considered largely ‘undruggable̵...
3D Enhancer–promoter networks provide predictive features for gene expression and coregulation in early embryonic lineages
3D Enhancer–promoter networks provide predictive features for gene expression and coregulation in early embryonic lineages
Mammalian embryogenesis commences with two pivotal and binary cell fate decisions that give rise to three essential lineag...
Transient protein folding in condensates reveals ways to target disordered oncoproteins
Transient protein folding in condensates reveals ways to target disordered oncoproteins
The androgen receptor forms nuclear condensates associated with gene transcription. Investigating the molecular basis of c...
Structural basis of branching during RNA splicing
Structural basis of branching during RNA splicing
Branching is a critical step in RNA splicing that is essential for 5′ splice site selection. Recent spliceosome stru...
Transport and inhibition mechanism of the human SGLT2–MAP17 glucose transporter
Transport and inhibition mechanism of the human SGLT2–MAP17 glucose transporter
Sodium–glucose cotransporter 2 (SGLT2) is imporant in glucose reabsorption. SGLT2 inhibitors suppress renal glucose ...
Complete set of the Atg8–E1–E2–E3 conjugation machinery forms an interaction web that mediates membrane shaping
Complete set of the Atg8–E1–E2–E3 conjugation machinery forms an interaction web that mediates membrane shaping
Atg8, a ubiquitin-like protein, is conjugated with phosphatidylethanolamine (PE) via Atg7 (E1), Atg3 (E2) and Atg12–...
The function of alternative splicing in the proteome: rewiring protein interactomes to put old functions into new contexts
The function of alternative splicing in the proteome: rewiring protein interactomes to put old functions into new contexts
Alternative splicing affects more than 95% of multi-exon genes in the human genome. These changes affect the proteome in a...
Author Correction: In vivo tracking of functionally tagged Rad51 unveils a robust strategy of homology search
Author notesThese authors contributed equally: Judith Miné-Hattab, Marie Villemeur.Authors and AffiliationsInstitut Curie,...
AGO2 localizes to the nucleus in quiescence and represses transposon expression
AGO2 localizes to the nucleus in quiescence and represses transposon expression
An Ago2HA/HA mouse model combined with super-resolution microscopy, molecular and biochemical assays allowed us to stringe...
POLQ to the rescue for double-strand break repair during mitosis
POLQ to the rescue for double-strand break repair during mitosis
DNA polymerase θ (POLQ) repairs mitotic DNA breaks; this requires RHINO and PLK1, averts genomic instability and may ...
Intra-promoter switch of transcription initiation sites in proliferation signaling-dependent RNA metabolism
Intra-promoter switch of transcription initiation sites in proliferation signaling-dependent RNA metabolism
Global changes in transcriptional regulation and RNA metabolism are crucial features of cancer development. However, littl...
Transcription start site choice diversifies mRNA isoforms and defines cancer cell behavior
Transcription start site choice diversifies mRNA isoforms and defines cancer cell behavior
We describe how transcription start site (TSS) choice of thousands of genes results in transcript isoforms with potential ...
Multidomain interactions and ring opening of the p97 ATPase by the UBXD1 adapter
Multidomain interactions and ring opening of the p97 ATPase by the UBXD1 adapter
The human ATPase p97 (also known as VCP) unfolds protein substrates by translocating them through its central channel. Thi...
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