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PRRG4 Brain-Specific Conditional Knockout Mice Display Autism Spectrum Disorder-Like Behaviors
PRRG4 Brain-Specific Conditional Knockout Mice Display Autism Spectrum Disorder-Like Behaviors
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized primarily by social deficits and repetitive ...
Heterogeneity and efficacy of immunotherapy in multiple cancer: insights from a meta-analysis
Heterogeneity and efficacy of immunotherapy in multiple cancer: insights from a meta-analysis
Immunotherapy has been recognized as a significant advancement in cancer treatment by promoting the body’s immune sy...
Piperlongumine Inhibits Lung Cancer Growth by Inducing Endoplasmic Reticulum Stress Leading to Suppression of M2 Macrophage Polarization
Piperlongumine Inhibits Lung Cancer Growth by Inducing Endoplasmic Reticulum Stress Leading to Suppression of M2 Macrophage Polarization
Lung cancer is the leading cause of cancer-related deaths globally. Prolonged targeted therapy use can lead to drug resist...
Mechanisms of drug resistance in hepatocellular carcinoma
Mechanisms of drug resistance in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the most prevalent form of primary liver cancer, associated with high morbidity and mort...
Recent Advances in mRNA-Based Vaccines Against Several Hepatitis Viruses
Recent Advances in mRNA-Based Vaccines Against Several Hepatitis Viruses
Viral hepatitis is a significant danger to global public health as it is the primary cause of mortality worldwide. Hepatit...
Development of a Large-Scale Pathogen Screening Test for the Biosafety Evaluation of Canine Mesenchymal Stem Cells
Development of a Large-Scale Pathogen Screening Test for the Biosafety Evaluation of Canine Mesenchymal Stem Cells
The action of mesenchymal stem cells (MSCs) is the subject of intense research in the field of regenerative medicine, incl...
MBD3 promotes epithelial-mesenchymal transition in gastric cancer cells by upregulating ACTG1 via the PI3K/AKT pathway
MBD3 promotes epithelial-mesenchymal transition in gastric cancer cells by upregulating ACTG1 via the PI3K/AKT pathway
Gastric cancer (GC) is a common malignancy and a leading cause of cancer-related death with high morbidity and mortality. ...
Screening of Natural Compounds for CYP11A1 Stimulation Against Cell Renal Cell Carcinoma
Screening of Natural Compounds for CYP11A1 Stimulation Against Cell Renal Cell Carcinoma
Renal cancer therapies are challenging owing to the extensive spreading of this cancer to other organs and its ability to ...
Musashi-2 Deficiency Triggers Colorectal Cancer Ferroptosis by Downregulating the MAPK Signaling Cascade to Inhibit HSPB1 Phosphorylation
Musashi-2 Deficiency Triggers Colorectal Cancer Ferroptosis by Downregulating the MAPK Signaling Cascade to Inhibit HSPB1 Phosphorylation
Musashi-2 (MSI2) is a critical RNA-binding protein (RBP) whose ectopic expression drives the pathogenesis of various cance...
D-allose Inhibits TLR4/PI3K/AKT Signaling to Attenuate Neuroinflammation and Neuronal Apoptosis by Inhibiting Gal-3 Following Ischemic Stroke
D-allose Inhibits TLR4/PI3K/AKT Signaling to Attenuate Neuroinflammation and Neuronal Apoptosis by Inhibiting Gal-3 Following Ischemic Stroke
Ischemic stroke (IS) occurs when a blood vessel supplying the brain becomes obstructed, resulting in cerebral ischemia. Th...
Visualisation of Bluetongue Virus in the Salivary Apparatus of Culicoides Biting Midges Highlights the Accessory Glands as a Primary Arboviral Infection Site
Visualisation of Bluetongue Virus in the Salivary Apparatus of Culicoides Biting Midges Highlights the Accessory Glands as a Primary Arboviral Infection Site
Arthropods transmit a wide range of pathogens of importance for the global health of humans, animals, and plants. One grou...
Extracellular Vesicles for Drug Delivery in Cancer Treatment
Extracellular Vesicles for Drug Delivery in Cancer Treatment
Extracellular vesicles (EVs) are nanoscale vesicles derived from cells that mediate intercellular communication by transpo...
Identification of exosome protein panels as predictive biomarkers for non-small cell lung cancer
Identification of exosome protein panels as predictive biomarkers for non-small cell lung cancer
Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related deaths worldwide, primarily due to its propen...
Comparison of two protocols for the generation of iPSC-derived human astrocytes
Comparison of two protocols for the generation of iPSC-derived human astrocytes
Astrocytes have recently gained attention as key contributors to the pathogenesis of neurodegenerative disorders including...
A Novel Dual-Reporter System Reveals Distinct Characteristics of Exosome-Mediated Protein Secretion in Human Cells
A Novel Dual-Reporter System Reveals Distinct Characteristics of Exosome-Mediated Protein Secretion in Human Cells
Exosomes, a special subtype of extracellular vesicles derived from human cells, serve as vital mediators of intercellular ...
Immune Activation Effects at Different Irradiated Sites and Optimal Timing of Radioimmunotherapy in Patients with Extensive-Stage Small Cell Lung Cancer: a Real-World Analysis
Immune Activation Effects at Different Irradiated Sites and Optimal Timing of Radioimmunotherapy in Patients with Extensive-Stage Small Cell Lung Cancer: a Real-World Analysis
In view of the limited data on radiotherapy (RT) combined with immunotherapy in patients with extensive-stage small cell l...
Correction: Circ‑ABCB10 knockdown inhibits the malignant progression of cervical cancer through microRNA‑128‑3p/ZEB1 axis
Correction: Circ‑ABCB10 knockdown inhibits the malignant progression of cervical cancer through microRNA‑128‑3p/ZEB1 axis
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
A high-throughput screening system for SARS-CoV-2 entry inhibition, syncytia formation and cell toxicity
A high-throughput screening system for SARS-CoV-2 entry inhibition, syncytia formation and cell toxicity
The entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into the host cell is mediated through the bindi...
Full spectrum flow cytometry-powered comprehensive analysis of PBMC as biomarkers for immunotherapy in NSCLC with EGFR-TKI resistance
Full spectrum flow cytometry-powered comprehensive analysis of PBMC as biomarkers for immunotherapy in NSCLC with EGFR-TKI resistance
Clinical studies suggest that immune checkpoint inhibitor (ICI) monotherapy has limited benefits in non-small cell lung ca...
LINC00853 contributes to tumor stemness of gastric cancer through FOXP3-mediated transcription of PDZK1IP1
LINC00853 contributes to tumor stemness of gastric cancer through FOXP3-mediated transcription of PDZK1IP1
The incidence and mortality of gastric cancer (GC) are high worldwide. Tumor stemness is a major contributor to tumorigene...
Trastuzumab-resistant breast cancer cells-derived tumor xenograft models exhibit distinct sensitivity to lapatinib treatment in vivo
Trastuzumab-resistant breast cancer cells-derived tumor xenograft models exhibit distinct sensitivity to lapatinib treatment in vivo
Resistance to HER2-targeted therapies, including the monoclonal antibody trastuzumab and tyrosine kinase inhibitor lapatin...
Integrating Omics and CRISPR Technology for Identification and Verification of Genomic Safe Harbor Loci in the Chicken Genome
Integrating Omics and CRISPR Technology for Identification and Verification of Genomic Safe Harbor Loci in the Chicken Genome
One of the most prominent questions in the field of transgenesis is ‘Where in the genome to integrate a transgene?&#...
Deinococcus radiodurans-derived membrane vesicles protect HaCaT cells against H2O2-induced oxidative stress via modulation of MAPK and Nrf2/ARE pathways
Deinococcus radiodurans-derived membrane vesicles protect HaCaT cells against H2O2-induced oxidative stress via modulation of MAPK and Nrf2/ARE pathways
Deinococcus radiodurans is a robust bacterium that can withstand harsh environments that cause oxidative stress to macromo...
A multi-omics analysis reveals CLSPN is associated with prognosis, immune microenvironment and drug resistance in cancers
A multi-omics analysis reveals CLSPN is associated with prognosis, immune microenvironment and drug resistance in cancers
Immunotherapy is effective only in limited patients. It is urgent to discover a novel biomarker to predict immune cells in...
Deep learning classification of uveal melanoma based on histopathological images and identification of a novel indicator for prognosis of patients
Deep learning classification of uveal melanoma based on histopathological images and identification of a novel indicator for prognosis of patients
Deep learning has been extensively used in digital histopathology. The purpose of this study was to test deep learning (DL...
Correction: Isolation and characterization of apical papilla cells from root end of human third molar and their differentiation into cementoblast cells: an in vitro study
Correction: Isolation and characterization of apical papilla cells from root end of human third molar and their differentiation into cementoblast cells: an in vitro study
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
TACE responser NDRG1 acts as a guardian against ferroptosis to drive tumorgenesis and metastasis in HCC
TACE responser NDRG1 acts as a guardian against ferroptosis to drive tumorgenesis and metastasis in HCC
The treatment efficacy of transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) varies widely between ...
Correction: The role of three‑dimensional scaffolds based on polyglycerol sebacate/ polycaprolactone/ gelatin in the presence of Nanohydroxyapatite in promoting chondrogenic differentiation of human adipose‑derived mesenchymal stem cells
Correction: The role of three‑dimensional scaffolds based on polyglycerol sebacate/ polycaprolactone/ gelatin in the presence of Nanohydroxyapatite in promoting chondrogenic differentiation of human adipose‑derived mesenchymal stem cells
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
BPTF in bone marrow provides a potential progression biomarker regulated by TFAP4 through the PI3K/AKT pathway in neuroblastoma
BPTF in bone marrow provides a potential progression biomarker regulated by TFAP4 through the PI3K/AKT pathway in neuroblastoma
Neuroblastoma (NB) is the most common extracranial malignant solid tumor in children, which is highly prone to bone marrow...
Exosomal microRNA-342-5p secreted from adipose-derived mesenchymal stem cells mitigates acute kidney injury in sepsis mice by inhibiting TLR9
Exosomal microRNA-342-5p secreted from adipose-derived mesenchymal stem cells mitigates acute kidney injury in sepsis mice by inhibiting TLR9
Sepsis-related acute kidney injury (AKI) is an inflammatory disease associated with extremely high mortality and health bu...
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