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Exploring interactions in microbial communities
Most microbial ecosystems cannot be understood without quantifying ecological interactions between their member species. G...
Understanding methanol metabolism through systems biology: advances and future perspectives
Methanol represents a promising sustainable one-carbon (C1) feedstock for biomanufacturing. However, limitations arising f...
Eubacterium limosum as a biocatalyst for sustainable methanol bioconversion
Eubacterium limosum is an acetogenic bacterium capable of utilizing one-carbon substrates — CO2, CO, formate, and methanol...
From marsh to market: taming Vibrio natriegens for sustainable bioproduction
As the fastest-growing bacterium known to date, Vibrio natriegens is rapidly emerging as a promising chassis for biotechno...
Production of chemicals by metabolically engineered Escherichia coli
Escherichia coli is increasingly employed for chemical production, with its industrial competitiveness now depending on bo...
Aromatic compound production by Corynebacterium glutamicum: unified strategies at the core and diversity by extension
Aromatic compounds are an important class of natural substances with a wide range of physiological functions and, thus, ap...
Unearth hidden terpenoids in plants by genome mining and synthetic biology
Plant terpenoids are a vital source of natural products, yet their discovery is often hindered by low abundance or cryptic...
Strategies for engineering domesticated and undomesticated human microbes
Human-associated microbes hold immense therapeutic potential, yet most species remain undomesticated due to cultivation ba...
Emerging strategies to enhance microbial natural product–based drug discovery
Natural products (NPs) have served as a major source of chemically novel, bioactive therapeutics for the treatment of vari...
Molecules to medicine: advances in metabolomics for natural product drug discovery
Recent advances in metabolomics are accelerating natural product (NP) drug discovery. NPs possess diverse biological relev...
Advances in the microbial biosynthesis of therapeutic terpenoids
Terpenoid natural products and their derivatives exhibit bioactivity that is utilized in FDA-approved drugs and candidates...
Programmable probiotics as next-generation living therapeutics: bridging synthetic biology and precision medicine
Volume 96, December 2025, 103375Author links open overlay panel, , , , Highlights•Engineered probiotics enable targeted, s...
Recent innovations in cannabinoid chemistry, biology, and biosynthesis
Cannabis sativa and related plants are recognized for their psychoactive and therapeutic effects due to the unique molecul...
Editorial overview: Microbial frontiers in environmental biotechnology
Dr. Mari Winkler is a Professor in the Civil and Environmental Engineering Department at the University of Washington, Sea...
Designed dietary fibers: engineering carbohydrate structure for precision modulation of the human gut microbiome
The human colonic microbiota exerts a profound influence on health, mediated by highly specific relationships among dietar...
Architectures of emerging biofoundry platforms for synthetic biology
Biofoundries are integrated, automated platforms that accelerate synthetic biology applications by facilitating high-throu...
Artificial intelligence–powered biofoundries for protein engineering and metabolic engineering
Synthetic biology is rapidly evolving through the integration of artificial intelligence (AI) and automated biofoundries. ...
Molecular methods for high-throughput, multiplexed, and automated genome editing in prokaryotes and eukaryotes
Novel approaches to genome engineering are crucial to rapidly advance the capabilities of strain engineering and synthetic...
Recent advances in AI-enabled automation of DNA assembly in biofoundries
Biofoundries are transforming synthetic biology, with the DNA assembly workflow being critical for successful biofoundry o...
Ionizable lipids empowered with artificial intelligence for mRNA delivery
Ionizable lipids are the most significant component of lipid nanoparticles and govern the ability to deliver mRNA in vitro...
Matchmaking at the cell surface using bispecifics to put cells on their best behavior
Intermolecular relationships at the cell surface dictate the behavior and regulatory network of cells. Such interactions o...
Engineered microbial living matter for diagnostics, prevention, and therapy
Living therapeutic and diagnostic materials based on engineered microorganisms are emerging as a novel approach with the p...
Effects of sewage sludge ash as a recycled phosphorus source on the soil microbiome
Incinerated byproducts of industrial, agricultural, or municipal processes have been used for centuries to improve soil pH...
New opportunities for biologically and chemically mediated adsorption and precipitation of phosphorus from wastewater
Biologically mediated adsorption and precipitation of phosphorus (P) from waste streams can restrict environmental P disch...
Wastewater biorefineries: exploring biological phosphorus removal and integrated recovery solutions
Phosphorus is an essential element for agriculture and a broad range of industrial and global food products [1]. It is pri...
Next-generation metabolic models informed by biomolecular simulations
Metabolic modeling is essential for understanding the mechanistic bases of cellular metabolism in various organisms, from ...
Comparing three emerging industrial cell factories: Pseudomonas putida KT2440, Halomonas bluephagenesis TD01, and Zymomonas mobilis ZM4
Entering the 21st century, major advancements in biotechnology, such as CRISPR/Cas [1] and omics technologies [2], have su...
Technoeconomic analysis for near-term scale-up of bioprocesses
Growing the bioeconomy requires products and pathways that are cost-competitive. Technoeconomic analyses (TEAs) aim to pre...
Zymomonas mobilis: bringing an ancient human tool into the genomic era
Decarbonization of the transportation sector is crucial for achieving net-zero emissions, but electrification is not yet f...
The tier system: a host development framework for bioengineering
Model host organisms for biomanufacturing are strains where the necessary experimental tools and fundamental data to direc...
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