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Ablation of ACSS2 drives alteration to cardiac and hepatic proteomic landscapes in a tissue- and sex-specific manner
Acetate is a key regulator of cellular metabolic dynamics. As a precursor for acetyl-CoA, acetate influences cellular ener...
Label-free proteomics revealed drought stress tolerance mechanisms in the sugar beet monosomic addition line M14
Drought, as a major threat to global agricultural production and food security, severely constrains crop yield primarily d...
The acetylation status and metabolic characterization of the HBV-induced macrophages
Hepatitis B virus (HBV) infection remains a major global health burden, affecting over 296 million people worldwide and ca...
Molecular diversity and antimicrobial properties of extracts from different organs of Tunisian extremophilic plants
Infectious diseases remain one of the leading causes of mortality worldwide, and antimicrobial resistance (AMR) is increas...
Novel high-resolution ion mobility mass spectrometry for site-specific quantification of the sirtuin-5 regulated kidney succinylome
Volume 327, 30 May 2026, 105625Author links open overlay panel, , , , , , , , Highlights•High-resolution ion mobility-mass...
First insight into the regulatory role of the glycoprotein hormones GPA2 and GPB5 in the small-spotted catshark (Scyliorhinus canicula L.) during spermiogenesis.
Volume 327, 30 May 2026, 105627Author links open overlay panel, , , Highlights•Catshark explants at late spermatid stages ...
Proteomic landscape of crotonylation and acetylation in pig testes across male reproduction
Post-translational modifications (PTMs) are covalent modifications that alter protein folding, localization, activity, and...
Integrative Astral-DIA proteomics and transcriptomics reveal candidate salt-tolerance genes in the halophyte Hordeum marinum
Soil salinization is a major constraint on global agricultural production. According to the Food and Agriculture Organizat...
A multi-omics comparison unveils convergent and divergent antidepressant mechanisms of fluoxetine and St. John's wort extract
Major depressive disorder (MDD) represents a significant global health burden, affecting millions of individuals worldwide...
Proteomics-driven innovations in plant-based foods: Current advances, emerging technologies, and future perspectives
The growing demand for plant-based foods is reshaping the global food system, driven by rising consumer concerns related t...
Comparative proteomics of amaranth and quinoa seeds reveals species-specific solubility traits of 11S globulins after Osborne and polarity-based extractions
Climate change is impacting food production yields and quality. In addition, the constant global population growth, which ...
Quantitative proteomics of intracellular and axenic amastigote-like forms of Trypanosoma cruzi under replicative and non-replicative conditions
Trypanosoma cruzi, the etiologic agent of Chagas disease, has a complex life cycle that involves both arthropods and mamma...
Peptidomics assessment of plant-based meat analogs produced by high-moisture extrusion: Analytical strategies, challenges, and future perspectives
In many regions, particularly Western countries, trending plant-based and flexitarian dietary patterns reflect the growing...
Small extracellular vesicles in clinical Cancer research - A quantitative proteomics perspective
Small extracellular vesicles (sEVs) are nanosized membrane-enclosed sacs secreted by living cells into the surrounding ext...
Structural diversity of lipid A modulates neutrophil proteome and secretome responses
The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium via the PRIDE [32] partner rep...
Comprehensive S-acylation profiling of the porcine epididymis and exosomes reveals a role in cargo sorting and long-distance trafficking
The epididymis regulates sperm maturation through multidimensional mechanisms [1]. During the 10–15 days transit process, ...
Proteomics in biopharmaceutical industries
Sample Preparation: robustness and reproducibility of enzymatic digestion, reagent quality, and potential peptide modifica...
Transmutation learning: Breaking the reference database barrier to unlock single-cell proteomics
Aline A.M. Martins: Writing – original draft, Investigation. Reynaldo Magalhães Melo: Writing – original draft, Conceptual...
Expanding the landscape of lysine acetylation stoichiometry and clinical impact
Lysine acetylation, once viewed primarily as a histone mark, is now recognized as a widespread regulator of protein functi...
Global profiling of protein lysine Malonylation during goat intramuscular Preadipocyte differentiation
Enhancing intramuscular fat (IMF) to improve the quality of livestock product has long been a goal in animal breeding. Rec...
Integrated proteomics and metabolomics analysis of chickpea seeds under aging condition
On a global scale, chickpeas hold the position of being the third most significant pulse crop in terms of production, foll...
Rice proteome revealed antagonistic interactions between signaling components of cytokinin and ABA phytohormones during drought stress
Plants respond and acclimatize to environmental stresses and maintain growth and productivity by modulating the expression...
Phosphoproteomics revealed salt stress tolerance mechanisms in the roots of sugar beet monomeric addition line M14
Soil salinity is a prevalent environmental factor affecting the cultivation of crops, usually due to the accumulation of i...
Potential use of serum microvesicle indicators to distinguish different types of drug-induced liver injury
Drug-induced liver injury (DILI) is the leading cause of acute liver failure, presenting with various manifestations such ...
Palaeoproteomic characterization of archaeological dental calculus reveals precarious periodontal health in pre-Roman Italy (7th–4th century BCE)
Periodontal diseases are chronic inflammatory conditions that affect the supporting structures of teeth, including the gin...
Comparative proteomic analysis of subcutaneous and intraperitoneal cysts of Echinococcus multilocularis
Alveolar echinococcosis (AE) is a lethal zoonotic disease caused by the Echinococcus multilocularis metacestode in animals...
Intercellular transfer of proteins and mitochondria - the contribution of proteomics
Intercellular communication is a fundamental process of all living things. Cells of the same, or different species, exchan...
Unraveling the mechanism of peptidases participation in the protein digestion of the whiteleg shrimp (Litopenaeus vannamei)
Volume 320, 15 September 2025, 105504Author links open overlay panel, , , , , Highlights•The protein metabolism enzymes in...
A perspective on integrating digital pathology, proteomics, clinical data and AI analytics in cancer research
Volume 320, 15 September 2025, 105493Author links open overlay panel, , , , , , , , , , Highlights•An integrative approach...
Corrigendum to “Metabonomics analysis reveals the protective effect of nano‑selenium against heat stress of rainbow trout (Oncorhynchus mykiss)” [Journal of Proteomics 259 (2022)104545/ID: JPROT-104545]
Volume 320, 15 September 2025, 105492Author links open overlay panelLanlan Li, Zhe Liu, Jinqiang Quan, Junhao Lu, Guiyan Z...
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