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Biophysical characterization of zinc and DNA binding properties of MRN complex interacting protein
Studies in immortalized human mitotic cells demonstrated that MRN Complex Interacting Protein (MRNIP) plays a critical rol...
Structural features of collagens of warm-blooded and cold-blooded animals that determine differences in their thermal stability
We have previously shown that the thermal stability of animal collagens correlates with the number of hydrophobic amino ac...
Structure of the type VI secretion protein VgrS from Salmonella Typhimurium
Enteric bacterial pathogens employ various strategies to colonize the intestine and cause diseases ranging from gastroente...
Structural characterization of Meiothermus ruber LOV domain
Light Oxygen Voltage (LOV) domains, members of the Per/Arnt/Sim (PAS) family, are blue light-responsive photosensors found...
GNN2Pfam: Integrating protein sequence and structure with graph neural networks for Pfam domain annotation
Proteins are building blocks of life, playing many crucial roles within organisms, such as catalyzing chemical reactions, ...
Corrigendum to “High-resolution single particle analysis using a scintillator camera XF416 on CRYOARM300II at 300 kV”. [J. Struct. Biol. 218(1) (2026) 108286]
Volume 218, Issue 1, March 2026, 108292Author links open overlay panelShinji Aramaki a b, Tomohito Tanihara c, Yuya Yoshid...
Corrigendum to “Crystal structure of glyoxysomal citrate synthase 3 from Arabidopsis thaliana reveals a Novel Oligomeric State”. [J. Struct. Biol. 218(1) (2026) 108293]
Volume 218, Issue 1, March 2026, 108296Author links open overlay panelKazuya Nishio a, Kenji Takagi b, Tsunehiro Mizushima...
Targeting Helicobacter pylori thymidylate kinase: structural insights and validation of novel inhibitors
Helicobacter pylori is a significant human pathogen, discovered by Warren and Marshall in 1982 (Ahmed, 2005). The human st...
“QuickStainer”: a rapid negative staining device for improved preservation of molecular structure
Volume 218, Issue 2, June 2026, 108299Author links open overlay panel, , , , , , , , Highlights•Negative staining is used ...
Comparative performance of structural aligners in functional domain annotation
Accurate protein domain annotation is essential for inferring protein function, and databases such as Pfam provide sequenc...
Linking protein aggregation and structural stability to predict pathogenic MYH7 variants via machine learning
MYH7 gene encodes for slow/β-myosin heavy chain (MyHC I) – the principal myosin isoform in both type-I skeletal fibers and...
ProPicker: Promptable segmentation for particle picking in cryogenic electron tomography
Cryo-electron tomography (cryo-ET) is gaining popularity due to its unique ability to image biological macromolecules in t...
3DDF-VAE: Dual-frequency variational autoencoder with pose-consistency validation for rare cryo-EM conformation discovery
Understanding the three-dimensional (3D) structure of biomacromolecules is essential for elucidating their biological func...
Effects of mineral nutrition on the cuticle structure of Armadillidium vulgare
Data will be made available on request.Biomineralization is a widespread strategy used by organisms to construct protectiv...
Molecular dynamics simulations refine the pathogenicity of ACVRL1 kinase domain variants by quantifying impacts on ATP binding in pulmonary arterial hypertension
Pulmonary Arterial Hypertension (PAH) is a severe, disabling disease characterized by an increase in pulmonary vascular re...
An inactive Zika NS2B-NS3pro protease construct for investigating allosteric inhibitors
Zika virus (ZIKV) is a mosquito-borne flavivirus that poses a significant global health threat, similar to related viruses...
Discovery and computational characterization of a novel cryptic pocket in human farnesyl pyrophosphate synthase
The mevalonate pathway provides isoprenoid building blocks required for the biosynthesis of more complex downstream produc...
Leveraging deep learning semantic segmentation for imaging coral skeletons
Semantic image segmentation is a popular technique that involves assigning semantic labels to pixels of images and has bee...
Binding of the elastin peptide VGVAPG and lactose to the human elastin binding protein
Elastin-derived peptides (EDPs) interact with elastin-binding protein (EBP), a key component of the elastin receptor compl...
Investigating oncolytic virus M1-Associated vesicles using 3D electron microscopy
Oncolytic viruses, which selectively infect and kill cancer cells, have emerged as a promising cancer treatment (Fountzila...
Computational identification of B and T-cell epitopes for designing a multi-epitope vaccine against SARS-CoV-2 spike glycoprotein
The COVID-19 pandemic continues to have a devastating impact worldwide, with over 776 million cumulative cases and more th...
Dengue virus-host interactions: Structural and mechanistic insights for future therapeutic strategies
Viral infections pose a major public health threat as they can spread rapidly and cause various diseases. These infections...
NMR and semi-synthesis in synergy to study protein regulation
Structural biology as a field has advanced immensely in the last few years, but the mechanistic roles of protein disordere...
Determinants of site-selectivity in human ileal bile acid-binding protein by NMR dynamic analysis of a functionally-impaired mutant
Backbone 1H and 15N chemical shifts together with 15N T1, T2, and -15N NOE relaxation data for the investigated complexes ...
Sequence/structural/functional relationships between Ganoderma fungal immunomodulatory proteins (gFIPs) and proteins involved in the modulation of immune response
Fungal Immunomodulatory Proteins (FIPs) are small, heat stable macromolecules, usually 110–114 amino acids long with molec...
Characterization of NMDA receptor Allostery modulation
N-methyl-D-aspartate receptors (NMDARs), are key components of ionotropic glutamate receptors (Hansen, 2018). It forms a d...
Insights into the pathogenic mechanisms associated with the SARS-CoV-2 spike protein
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the pathogenic agent responsible for the coronavirus disease...
A structural perspective of transmembrane transport of zinc by ZnT and ZIP transporters
As an essential trace element, zinc is crucial for the development and function in mammals. It is estimated that over 10 %...
1-Deoxy-D-xylulose 5-phosphate synthase: structural perspectives on an essential enzyme in isoprenoid biosynthesis
Isoprenoids represent one of the largest and functionally diverse class of natural products, playing essential roles in ce...
A generalist deep-learning volume segmentation tool for volume electron microscopy of biological samples
Volume 217, Issue 3, September 2025, 108214Author links open overlay panel, , , , , Highlights•A deep learning-based tool ...
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