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Cis‐regulation of antisense noncoding RNA at the JAZF1 locus in type 2 diabetes
Cis‐regulation of antisense noncoding RNA at the JAZF1 locus in type 2 diabetes
Abstract Background Several genomic loci of type 2 diabetes (T2D) nominated in genome-wide association studies (GWASs) hav...
Long noncoding RNA SNHG9 facilitates growth of glioma stem‐like cells via miR‐326/SOX9 axis
Long noncoding RNA SNHG9 facilitates growth of glioma stem‐like cells via miR‐326/SOX9 axis
Abstract Background Glioma stem-like cells (GSCs) are greatly responsible for the progression of glioma. Long noncoding RN...
Association study of miR‐149, miR‐196a2, and miR‐499a polymorphisms with coronary artery aneurysm of Kawasaki disease in southern Chinese population
Association study of miR‐149, miR‐196a2, and miR‐499a polymorphisms with coronary artery aneurysm of Kawasaki disease in southern Chinese population
Abstract Background Accumulating evidence suggests that several microRNA (miRNA) polymorphisms are closely associated with...
A novel variant of C12orf4 linked to autosomal recessive intellectual disability type 66 with phenotype expansion
A novel variant of C12orf4 linked to autosomal recessive intellectual disability type 66 with phenotype expansion
Abstract Background Intellectual disability (ID) is a hallmark of many rare disorders that are highly heterogeneous and co...
LINC01291 promotes hepatocellular carcinoma development by targeting the miR‐186‐5p/OXSR1 axis
LINC01291 promotes hepatocellular carcinoma development by targeting the miR‐186‐5p/OXSR1 axis
Abstract Background Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Recent studies have demons...
CDK14/β‐catenin/TCF4/miR‐26b positive feedback regulation modulating pancreatic cancer cell phenotypes in vitro and tumor growth in mice model in vivo
CDK14/β‐catenin/TCF4/miR‐26b positive feedback regulation modulating pancreatic cancer cell phenotypes in vitro and tumor growth in mice model in vivo
Abstract Introduction Chemotherapy and radiotherapy have been reported to be basically ineffective for pancreatic ductal a...
Circular RNA circ_0040823 inhibits the proliferation of acute myeloid leukemia cells and induces apoptosis by regulating miR‐516b/PTEN
Circular RNA circ_0040823 inhibits the proliferation of acute myeloid leukemia cells and induces apoptosis by regulating miR‐516b/PTEN
Abstract Objective Endogenous circular RNAs (circRNAs) and microRNAs (miRNAs) have been shown to regulate the pathogenesis...
Noninvasive detection of fetal genetic variations through polymorphic site sequencing of maternal plasma DNA
Noninvasive detection of fetal genetic variations through polymorphic site sequencing of maternal plasma DNA
Abstract Background Noninvasive prenatal testing (NIPT) for common fetal aneuploidies has been widely adopted in clinical ...
Silencing of circDPP4 suppresses cell progression of human prostate cancer and enhances docetaxel cytotoxicity through regulating miR‐564/ZIC2 axis
Silencing of circDPP4 suppresses cell progression of human prostate cancer and enhances docetaxel cytotoxicity through regulating miR‐564/ZIC2 axis
Abstract Background Circular RNA derived from dipeptidyl peptidase 4 (circDPP4; ID: hsa_circ_0056881) is one top increased...
Global Brain Delivery of Neuroligin 2 Gene Ameliorates Seizures in A Mouse Model of Epilepsy
Global Brain Delivery of Neuroligin 2 Gene Ameliorates Seizures in A Mouse Model of Epilepsy
Abstract Background Despite the increasing availability of effective drugs, around one-third of patients with epilepsy are...
Noninvasive Detection of Fetal Genetic Variations through Polymorphic Sites Sequencing of Maternal Plasma DNA
Noninvasive Detection of Fetal Genetic Variations through Polymorphic Sites Sequencing of Maternal Plasma DNA
Abstract Background Non-invasive prenatal testing (NIPT) for common fetal aneuploidies has been widely adopted in clinical...
Design of a new cell penetrating peptide for DNA, siRNA and mRNA delivery
Design of a new cell penetrating peptide for DNA, siRNA and mRNA delivery
Abstract Background Delivery systems, including peptide-based ones, that destabilize endosomes in a pH-dependent manner ar...
Human leukocyte antigen class I association with occult hepatitis B virus infection in the Shaanxi Han group: Analysis at the haplotype level
Human leukocyte antigen class I association with occult hepatitis B virus infection in the Shaanxi Han group: Analysis at the haplotype level
Abstract Background Human leucocyte antigen (HLA) class I genes and haplotypes correlate with hepatitis B virus (HBV) infe...
AGER gene variant as a risk factor for juvenile idiopathic arthritis
AGER gene variant as a risk factor for juvenile idiopathic arthritis
Abstract Background The AGER gene encodes a cell surface multiligand receptor of advanced glycation end-products that are ...
A novel compound heterozygous variant linked to hematuria in a family with hereditary factor VII deficiency
A novel compound heterozygous variant linked to hematuria in a family with hereditary factor VII deficiency
Abstract Background Hereditary Factor VII Deficiency (FVIID) is a rare congenital autosomal recessive bleeding disorder. I...
The pathological tissue expression pattern and clinical significance of m6A‐regulatory genes in non‐small cell lung cancer
The pathological tissue expression pattern and clinical significance of m6A‐regulatory genes in non‐small cell lung cancer
Abstract Background Aberrant expression of m6A-related proteins contributes to the occurrence and progression of non-small...
Marked Increase in Tumor Transfection with a Truncated Branched Polymer
Marked Increase in Tumor Transfection with a Truncated Branched Polymer
Abstract Background We previously determined that polyplexes formed by linear H2K peptides were more effective in transfec...
LINC01291 promotes hepatocellular carcinoma development by targeting miR‐186‐5p/OXSR1 axis
LINC01291 promotes hepatocellular carcinoma development by targeting miR‐186‐5p/OXSR1 axis
Abstract Background Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Recent studies have demons...
EZH2 upregulates the expression of MAPK1 to promote intervertebral disc degeneration via suppression of miR‐129‐5p
EZH2 upregulates the expression of MAPK1 to promote intervertebral disc degeneration via suppression of miR‐129‐5p
Abstract Background This study was designed to verify whether enhancer of zeste homolog 2 (EZH2) affects intervertebral di...
Human Leukocyte Antigen Class I Association with Occult Hepatitis B Virus Infection in Shaanxi Han Group: Analysis at the Haplotype Level
Human Leukocyte Antigen Class I Association with Occult Hepatitis B Virus Infection in Shaanxi Han Group: Analysis at the Haplotype Level
Abstract Background Previous researches have confirmed that human leucocyte antigen (HLA) class I genes and haplotypes wer...
Inhibition of lncRNA MALAT1 reduces myocardial ischemia‐reperfusion injury of rat cardiomyocytes through regulating the miR‐135a‐5p/HIF1AN axis
Inhibition of lncRNA MALAT1 reduces myocardial ischemia‐reperfusion injury of rat cardiomyocytes through regulating the miR‐135a‐5p/HIF1AN axis
Abstract Background Many studies have elucidated the regulatory roles of long non-coding RNAs in cardiovascular diseases. ...
Circular RNA ITCH attenuates the progression of nasopharyngeal carcinoma by inducing PTEN upregulation via miR‐214
Circular RNA ITCH attenuates the progression of nasopharyngeal carcinoma by inducing PTEN upregulation via miR‐214
Abstract Background Circular RNA itchy E3 ubiquitin protein ligase (circ-ITCH) has previously been reported to play a key ...
LncRNA CDKN2B‐AS1 contributes to glioma development by regulating the miR‐199a‐5p/DDR1 axis
LncRNA CDKN2B‐AS1 contributes to glioma development by regulating the miR‐199a‐5p/DDR1 axis
Abstract Background Although cyclin-dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1) is upregulated in glioma, i...
CSRP3, p.Arg122*, is Responsible for Hypertrophic Cardiomyopathy in a Chinese Family
CSRP3, p.Arg122*, is Responsible for Hypertrophic Cardiomyopathy in a Chinese Family
Abstract Background Hypertrophic cardiomyopathy (HCM) is a hereditary disease manifested by a thickened ventricular wall. ...
Hsa_circ_0040809 regulates colorectal cancer development by upregulating methyltransferase DNMT1 via targeting miR‐515‐5p
Hsa_circ_0040809 regulates colorectal cancer development by upregulating methyltransferase DNMT1 via targeting miR‐515‐5p
Abstract Background Circular RNAs (circRNAs) are key regulators in the progression of various cancers. Abnormal DNA methyl...
Hsa_circ_0040809 regulates colorectal cancer development by up‐regulating methyltransferase DNMT1 via targeting miR‐515‐5p
Hsa_circ_0040809 regulates colorectal cancer development by up‐regulating methyltransferase DNMT1 via targeting miR‐515‐5p
Abstract Background Circular RNAs (circRNAs) are key regulators in the progression of various cancers. Abnormal DNA methyl...
The diagnostic significance of circulating lncRNA ADAMTS9‐AS2 tumor biomarker in non‐small cell lung cancer among the Egyptian population
The diagnostic significance of circulating lncRNA ADAMTS9‐AS2 tumor biomarker in non‐small cell lung cancer among the Egyptian population
Abstract Background Long non-coding RNA ADAM metallopeptidase with thrombospondin type 1 motif, 9 antisense RNA 2 (ADAMTS9...
Inhibition of the long non‐coding RNA UNC5B‐AS1/miR‐4455/RSPO4 axis reduces cervical cancer growth in vitro and in vivo
Inhibition of the long non‐coding RNA UNC5B‐AS1/miR‐4455/RSPO4 axis reduces cervical cancer growth in vitro and in vivo
Abstract Background Long non-coding RNAs (lncRNAs) are significant regulatory factors for the initiation and development o...
Copy number variation characterization and possible candidate genes in miscarriage and stillbirth by next‐generation sequencing analysis
Copy number variation characterization and possible candidate genes in miscarriage and stillbirth by next‐generation sequencing analysis
Abstract Background The present study aimed to explore the etiological relationship between miscarriage and stillbirth and...
Synovial mesenchymal stem cell‐derived extracellular vesicles containing microRN555A‐26a‐5p ameliorate cartilage damage of osteoarthritis
Synovial mesenchymal stem cell‐derived extracellular vesicles containing microRN555A‐26a‐5p ameliorate cartilage damage of osteoarthritis
Abstract Background Osteoarthritis (OA) is a degenerative disease characterized by cartilage damage. We aimed to improve t...
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