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Real-World Daptomycin Use with a focus on muscle toxicity: A multicentric retrospective study
Over the past decades, the incidence of healthcare-associated infections has risen, notably due to multidrug-resistant bac...
Global epidemiological trend of Klebsiella pneumoniae ST23: emergence of KL57 lineage carrying dual carbapenemases
Klebsiella pneumoniae is an opportunistic pathogen that can cause both hospital- and community-acquired infections worldwi...
Downregulation of an NfsA-like nitroreductase causes metronidazole resistance in Gardnerella vaginalis
Volume 67, Issue 2, February 2026, 107681Author links open overlay panel, , , , , Highlights•Gardnerella vaginalis encodes...
Machine–learning and gene–synergy networks reveal interpretable drivers of antibiotic resistance in Staphylococcus aureus
Staphylococcus aureus (S. aureus) causes more than 100 000 deaths worldwide annually owing to antimicrobial resistance (AM...
Enhanced molecular surveillance for gonococcal resistance during doxycycline post-exposure prophylaxis implementation
Epidemiological data reveal that over 1 million individuals aged 15–49 worldwide are infected with curable sexually transm...
Fosfomycin-based combinations against carbapenemase-producing Klebsiella pneumoniae bloodstream infections: Correlating in vitro synergy with clinical outcomes
Antimicrobial resistance is a serious global health threat, projected to cause up to 10 million deaths annually and substa...
EnvZ mutation–driven downregulation of catecholate siderophore receptors and concurrent TonB complex repression confer cefiderocol resistance in a KPC-producing ST11-KL64 hypervirulent Klebsiella pneumoniae
Around the world, Klebsiella pneumoniae is a pathogen of great clinical importance as it results in severe community-acqui...
Antibiotic class comparisons for the treatment of pyelonephritis and complicated urinary tract infections: A systematic review and meta-analysis
BackgroundThe relative efficacy of antibiotic classes for pyelonephritis and complicated UTI (cUTI) remains unclear, as di...
Enhancing meropenem therapy in critical care: A retrospective study of PK/PD target attainment and therapeutic drug monitoring
BackgroundMeropenem is a first-line treatment for severe infections; however, its efficacy is increasingly compromised by ...
Zinc deficiency reverses biofilm azole resistance in Candida albicans
Candida albicans is a prevalent opportunistic pathogenic fungus [1]. On October 25, 2022, the World Health Organization is...
Development of ceftazidime–avibactam resistance driven by conversion of blaKPC-2 to blaKPC-78 during treatment of ST463 carbapenem-resistant Pseudomonas aeruginosa infection
Carbapenem-resistant Pseudomonas aeruginosa (CRPA) is a significant pathogen in hospital-acquired infections [1]. Owing to...
Ceftazidime/avibactam and ceftolozane/tazobactam for severe paediatric infections: A systematic review, meta-analysis, and evidence map
Volume 67, Issue 2, February 2026, 107710Author links open overlay panelPaula Pimenta-de-Souza a, Alice Ramos-Silva a, Val...
ATP-binding cassette transporters mediate and regulate metronidazole resistance in Clostridioides difficile
Clostridioides difficile infection (CDI) has become one of the emerging challenges in infectious and digestive diseases. T...
Effect of ibuprofen on the pharmacokinetics of intravenous flucloxacillin in healthy adults
Volume 67, Issue 2, February 2026, 107684Author links open overlay panel, , , , , , AbstractObjectiveIbuprofen is frequent...
Formation of a novel multiresistance plasmid co-carrying tigecycline, carbapenem, and other resistance genes by recombination during conjugative transfer in Klebsiella pneumoniae
Antimicrobial resistance, particularly in Gram-negative bacteria, has become one of the most critical global health challe...
Vancomycin clearance compared to creatinine clearance by timed urine collection in the intensive care unit
Volume 67, Issue 2, February 2026, 107704Author links open overlay panel, , , Highlights•Vancomycin’s nonrenal clearance m...
In reply to the letter to editor regarding “Comparison of ceftazidime-avibactam with other appropriate antimicrobial therapy for the treatment of OXA-48- or KPC-producing Enterobacterales infections in Turkiye: A multi-centre retrospective matched-cohort study”
Check access to the full text by signing in through your organization.© 2025 Elsevier Ltd and International Society of Ant...
Aztreonam–avibactam pharmacokinetics during extracorporeal membrane oxygenation support: First insights from a case report
Check access to the full text by signing in through your organization.© 2025 Elsevier Ltd and International Society of Ant...
Comments on ‘Acute kidney injury associated with colistin sulphate vs. polymyxin B sulphate therapy: A real-world, retrospective cohort study’
Check access to the full text by signing in through your organization.© 2025 Elsevier Ltd and International Society of Ant...
Superintegron of Vibrio paracholerae as a reservoir of antibiotic resistance genes
All content on this site: Copyright © 2026 Elsevier B.V., its licensors, and contributors. All rights are reserved, includ...
Restoring tigecycline efficacy with lysine supplementation in tmexCD-toprJ-positive bacteria
The discovery of penicillin revolutionized medicine, marking the beginning of the antibiotic era and driving advancements ...
Procalcitonin-guided early cessation of antibiotics prevents gut inflammation and preserves gut microbiome: Data from the PROGRESS controlled trial
GP has received honoraria and/or consulting fees from AstraZeneca, Gilead, GSK, Menarini, MSD, Norma, Pfizer and SOBI, and...
Cellular and genetic changes during and after fluconazole exposure in Cryptococcus neoformans
The validity of genome replication is fundamental to fungal survival, and errors in this process can result in ploidy chan...
Cerebrospinal fluid concentrations of ceftaroline and ceftazidime/avibactam in healthy volunteers: Pharmacokinetics and probability of target attainment
Volume 66, Issue 2, August 2025, 107512Author links open overlay panel, , , , , , , , , , , , , Highlights•Ceftaroline, ce...
High-level ceftazidime-avibactam resistance by in-host evolution of blaKPC genes: Emergence of a novel blaKPC-102 variant and increase of blaKPC-33 copy number in Klebsiella pneumoniae strains from a lung transplantation recipient
Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-Kp) has been increasingly highlighted as a major th...
Association of antibiotics with Stevens–Johnson syndrome and toxic epidermal necrolysis: A real-world pharmacovigilance study
Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare and severe immune-mediated adverse reactions ...
Assessment of Dientamoeba fragilis interhuman transmission by fecal microbiota transplantation
Funding: The COSMIC cohort is supported by a COMAD grant from Société Nationale Francaise de Gastroenterologie (SNFGE) and...
Individualised amoxicillin-clavulanate dosing recommendations for critically ill children with augmented clearance after cardiac surgery
With a reported incidence up to 24%, postoperative infections present a significant complication in neonates and children ...
Characterisation of the genome of a Klebsiella pneumoniae clinical strain carrying a novel KPC-205 variant associated with resistance to ceftazidime/avibactam and cefiderocol
Cookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2025 Elsevier B.V., its licensors, an...
Commentary on “Development and validation of a time-varying correction factor for QT interval assessment in drug-resistant tuberculosis patients”
Cookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2025 Elsevier B.V., its licensors, an...
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