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Transcription attenuation amplifies collateral vulnerabilities in rifampicin-resistant Mycobacterium tuberculosis
Transcription attenuation amplifies collateral vulnerabilities in rifampicin-resistant Mycobacterium tuberculosis
Mycobacterium tuberculosis (Mtb) acquires resistance to rifampicin (Rif) through mutations in the β-subunit of RNA po...
A method that TRACS multi-species transmission at scale
A method that TRACS multi-species transmission at scale
TRAnsmission Clustering of Strains (TRACS) is a versatile and highly scalable computational tool that infers strain-level ...
Author Correction: Acarbose redirects gut microbiome utilization of dietary carbohydrates to suppress anaphylaxis in mice
Research Center for Drug Discovery, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, T...
Bridging classical and continuous directed evolution
Bridging classical and continuous directed evolution
Continuous evolution methods accelerate directed evolution campaigns, but often at the expense of control over evolutionar...
A microbiologist’s voyage from the lab to The Atlantic
A microbiologist’s voyage from the lab to The Atlantic
We spoke with Katherine Wu, a staff writer at The Atlantic, about her career path from infectious disease research to scie...
Preserving the future of vaccine science in the USA
Preserving the future of vaccine science in the USA
Vaccines have saved an estimated 154 million lives in 50 years, yet that infrastructure is under threat. We highlight the ...
Spatial and genetic constraints govern transcription–translation coupling and mRNA degradation in bacteria
Spatial and genetic constraints govern transcription–translation coupling and mRNA degradation in bacteria
Bacterial gene expression is thought to involve tightly coupled transcription, translation and mRNA degradation. However, ...
Seasonality of lake microbial denitrification and its sensitivity to climate warming
Seasonality of lake microbial denitrification and its sensitivity to climate warming
Lakes are expected to experience longer summer stratification and shorter winter mixing due to climate-induced warming. Th...
Identified receptors shed light on Epstein–Barr virus infection
Identified receptors shed light on Epstein–Barr virus infection
Epstein–Barr virus is associated with cancer and implicated in autoimmune diseases. Three studies reveal desmocollin...
How nutrient starvation impacts the gut microbiome
How nutrient starvation impacts the gut microbiome
Even when the gut is rich in nutrients, microorganisms can experience nutrient deprivation owing to factors such as fluctu...
Publisher Correction: Rational design of a hospital-specific phage cocktail to treat Enterobacter cloacae complex infections
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Why editors go to conferences
You may have spotted us at different conferences and wondered what we’re doing amid active researchers. Here, we dem...
Structure of a distinct β-barrel assembly machinery complex in the Bacteroidota
Structure of a distinct β-barrel assembly machinery complex in the Bacteroidota
The Gram-negative β-barrel assembly machinery (BAM) complex catalyses the folding and membrane insertion of newly syn...
Superinfection promotes replication and diversification of defective HIV-1 proviruses in people with non-suppressible viraemia
Superinfection promotes replication and diversification of defective HIV-1 proviruses in people with non-suppressible viraemia
During replication of some RNA viruses, defective particles can spontaneously arise and interfere with wild-type (WT) viru...
A generative artificial intelligence approach for the discovery of antimicrobial peptides against multidrug-resistant bacteria
A generative artificial intelligence approach for the discovery of antimicrobial peptides against multidrug-resistant bacteria
The discovery of novel antimicrobial peptides (AMPs) against clinical superbugs is urgently needed to address the ongoing ...
Discovery and artificial intelligence-guided mechanistic elucidation of a narrow-spectrum antibiotic
Discovery and artificial intelligence-guided mechanistic elucidation of a narrow-spectrum antibiotic
Current clinical antibiotics are largely broad-spectrum agents that can alter the gut microbiome and promote colonization ...
Effect of broccoli sprout extract and baseline gut microbiota on fasting blood glucose in prediabetes: a randomized, placebo-controlled trial
Effect of broccoli sprout extract and baseline gut microbiota on fasting blood glucose in prediabetes: a randomized, placebo-controlled trial
More effective treatments are needed for impaired fasting glucose or glucose intolerance, known as prediabetes. Sulforapha...
Influenza A virus rapidly adapts particle shape to environmental pressures
Influenza A virus rapidly adapts particle shape to environmental pressures
Enveloped viruses such as influenza A virus (IAV) often produce a mixture of virion shapes, ranging from 100 nm sphe...
Gut microbiota-derived hexa-acylated lipopolysaccharides enhance cancer immunotherapy responses
Gut microbiota-derived hexa-acylated lipopolysaccharides enhance cancer immunotherapy responses
The gut microbiome modulates immunotherapy treatment responses, and this may explain why immune checkpoint inhibitors, suc...
Upcycling of polyamides through chemical hydrolysis and engineered Pseudomonas putida
Upcycling of polyamides through chemical hydrolysis and engineered Pseudomonas putida
Aliphatic polyamides, or nylons, are widely used in the textile and automotive industry due to their high durability and t...
Publisher Correction: SAMPL-seq reveals micron-scale spatial hubs in the human gut microbiome
Ravi U. ShethPresent address: Kingdom Supercultures, Brooklyn, NY, USADepartment of Systems Biology, Columbia University, ...
Structural insights into tecovirimat antiviral activity and poxvirus resistance
Structural insights into tecovirimat antiviral activity and poxvirus resistance
Mpox is a zoonotic disease endemic to Central and West Africa. Since 2022, two human-adapted monkeypox virus (MPXV) strain...
ILC3s regulate the gut microbiota via host intestinal galactosylation to limit pathogen infection in mice
ILC3s regulate the gut microbiota via host intestinal galactosylation to limit pathogen infection in mice
Host immunity and commensal bacteria synergistically maintain intestinal homeostasis and mediate colonization resistance a...
Close the gender gap in Africa’s HIV epidemic
Close the gender gap in Africa’s HIV epidemic
Improving HIV interventions for men could reduce HIV acquisition in women, close the growing gender gap in HIV infections ...
Bacteroides fragilis ubiquitin homologue drives intraspecies bacterial competition in the gut microbiome
Bacteroides fragilis ubiquitin homologue drives intraspecies bacterial competition in the gut microbiome
Interbacterial antagonism and associated defensive strategies are both essential during bacterial competition. The human g...
BACH1 promotes tissue necrosis and Mycobacterium tuberculosis susceptibility
BACH1 promotes tissue necrosis and Mycobacterium tuberculosis susceptibility
Oxidative stress triggers ferroptosis, a form of cellular necrosis characterized by iron-dependent lipid peroxidation, and...
Placental group B Streptococcus is associated with increased risk of adverse foetal outcome
Placental group B Streptococcus is associated with increased risk of adverse foetal outcome
The placenta nourishes the foetus and supports its development and growth. Our study now identifies the placenta as a pote...
Longitudinal population-level HIV epidemiologic and genomic surveillance highlights growing gender disparity of HIV transmission in Uganda
Longitudinal population-level HIV epidemiologic and genomic surveillance highlights growing gender disparity of HIV transmission in Uganda
HIV incidence in eastern and southern Africa has historically been concentrated among girls and women aged 15–24 yea...
Tackling climate change and deforestation to protect against vector-borne diseases
Tackling climate change and deforestation to protect against vector-borne diseases
The spread of vector-borne infectious diseases is driven by a complex array of environmental and social drivers, including...
Small organisms with big climate impact
Small organisms with big climate impact
To coincide with the 28th United Nations Climate Change Conference (COP28), taking place in Dubai, United Arab Emirates, w...
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