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Schrodinger’s Pricing: Conceptual and Practical Challenges of Conditional PAS in the NICE Technology Appraisal of Lorlatinib for Untreated ALK-Positive Advanced Non-small-cell Lung Cancer (Review of TA1103): An External Assessment Group Perspective
Schrodinger’s Pricing: Conceptual and Practical Challenges of Conditional PAS in the NICE Technology Appraisal of Lorlatinib for Untreated ALK-Positive Advanced Non-small-cell Lung Cancer (Review of TA1103): An External Assessment Group Perspective
NICE invited Pfizer to submit evidence on the clinical and cost effectiveness of lorlatinib for previously untreated ALK-p...
Ten Recommendations for Modelling Cost Effectiveness of Screening: Perspectives of an International Stakeholder Group
Ten Recommendations for Modelling Cost Effectiveness of Screening: Perspectives of an International Stakeholder Group
Modelling the cost effectiveness of screening interventions presents unique challenges. These relate to a lack of knowledg...
Economic Burden of Idiopathic Pulmonary Fibrosis: Updated Evidence on Costs and Resource Use
Economic Burden of Idiopathic Pulmonary Fibrosis: Updated Evidence on Costs and Resource Use
Idiopathic pulmonary fibrosis is a rare progressive respiratory disease associated with high morbidity, poor survival and ...
Public Health Impact and Cost-Effectiveness of Revising the Adolescent Meningococcal Vaccine Schedule in the United States
Public Health Impact and Cost-Effectiveness of Revising the Adolescent Meningococcal Vaccine Schedule in the United States
In 2025, invasive meningococcal disease (IMD) vaccination in United States (US) adolescents consisted of two standard of c...
Component Clinical and Cost Outcomes Complementing Value of Information: Case Study of a Tuberculosis Diagnostics Clinical Trial
Component Clinical and Cost Outcomes Complementing Value of Information: Case Study of a Tuberculosis Diagnostics Clinical Trial
Conventional value-of-information (VOI) analysis bases decisions on a composite cost-effectiveness measure that aggregates...
Cost-Effectiveness of Immunising Interventions to Reduce Respiratory Syncytial Virus Disease Burden in Infants in Australia
Cost-Effectiveness of Immunising Interventions to Reduce Respiratory Syncytial Virus Disease Burden in Infants in Australia
Two immunising products are emerging to prevent the burden of respiratory syncytial virus (RSV) in infants: long-lasting m...
Evaluating the Cost Effectiveness of Rapid Diagnostic Testing for the Identification of Pathogens and Resistance Genes in Bloodstream Infections
Evaluating the Cost Effectiveness of Rapid Diagnostic Testing for the Identification of Pathogens and Resistance Genes in Bloodstream Infections
Bloodstream infections (BSI) are a leading cause of mortality worldwide. Rapid detection of the causative pathogen can hel...
Economic Evaluation of the Addition of Vancomycin to Cefazolin Prophylaxis in Patients Undergoing Arthroplasty
Economic Evaluation of the Addition of Vancomycin to Cefazolin Prophylaxis in Patients Undergoing Arthroplasty
The addition of a glycopeptide antimicrobial to cephalosporin therapy has been reportedly adopted in practice to prevent s...
Lifetime Effects of Adherence to Cardiovascular and Diabetes Medications in Spain: A Modelling Study in a Population Cohort of 152,117 Patients
Lifetime Effects of Adherence to Cardiovascular and Diabetes Medications in Spain: A Modelling Study in a Population Cohort of 152,117 Patients
Non-adherence to cardiovascular disease (CVD) treatments leads to suboptimal health outcomes and increased healthcare and ...
A Modern Approach for Constructing Decision Analytic Models in Microsoft Excel
A Modern Approach for Constructing Decision Analytic Models in Microsoft Excel
The majority of decision analytic models submitted to health technology assessment (HTA) agencies are developed using Micr...
The Cost Utility of Rhythm Control Treatment Sequences in Patients with Atrial Fibrillation: Anti-arrhythmic Drugs Versus Catheter Ablation
The Cost Utility of Rhythm Control Treatment Sequences in Patients with Atrial Fibrillation: Anti-arrhythmic Drugs Versus Catheter Ablation
Despite evidence on the cost effectiveness of catheter ablation (CA) as a rhythm control strategy in patients with atrial ...
Chronic Kidney Disease (CKD): Systematic Review of the Cost Effectiveness of SGLT2 Inhibitors and Other Novel Nephroprotective Drugs
Chronic Kidney Disease (CKD): Systematic Review of the Cost Effectiveness of SGLT2 Inhibitors and Other Novel Nephroprotective Drugs
Chronic kidney disease (CKD) is a major global cause of morbidity and mortality. Recent nephroprotective therapies have im...
Economic Evaluation of Pre-emptive Pharmacogenetic Panel Testing versus No Genetic Testing in a Multi-ethnic Asian Population
Economic Evaluation of Pre-emptive Pharmacogenetic Panel Testing versus No Genetic Testing in a Multi-ethnic Asian Population
The cost–utility of a panel-based pre-emptive pharmacogenomic (PPGx) test has not been evaluated in a multi...
The Economic Burden of Duchenne Muscular Dystrophy: A Systematic Review
The Economic Burden of Duchenne Muscular Dystrophy: A Systematic Review
Duchenne muscular dystrophy (DMD) is a rare, progressive, severely disabling and ultimately fatal genetic neuromuscular di...
Key Considerations for Assessing Real-World Comparative Effectiveness in the Context of the Drug Price Negotiation Program: A Case Study of Pembrolizumab
Key Considerations for Assessing Real-World Comparative Effectiveness in the Context of the Drug Price Negotiation Program: A Case Study of Pembrolizumab
The Centers for Medicare and Medicaid Services increasingly rely on real-world evidence to inform drug price negotiations ...
The Psychometric Performance of Generic Preference-Based Measures in Informal Carers: A Systematic Review of Validation Studies
The Psychometric Performance of Generic Preference-Based Measures in Informal Carers: A Systematic Review of Validation Studies
A growing number of health technology assessment agencies recommend inclusion of informal carer outcomes in health economi...
The Burden of Informal Caregiving for Adults with Musculoskeletal Conditions: A Systematic Review
The Burden of Informal Caregiving for Adults with Musculoskeletal Conditions: A Systematic Review
Informal caregivers play a critical role in supporting individuals with musculoskeletal conditions. This systematic review...
Integrating Environmental Impact in Health Technology Assessment: An Exploratory Study
Integrating Environmental Impact in Health Technology Assessment: An Exploratory Study
To what extent a care pathway, due to its associated pollution, may be more detrimental to future health than beneficial t...
Challenges and Criteria for Single-Arm Trials Leading to an Added Benefit in German Health Technology Assessments
Challenges and Criteria for Single-Arm Trials Leading to an Added Benefit in German Health Technology Assessments
Randomized controlled trials are the standard for health technology assessment, but when they are infeasible or unethical,...
Can We Make Health Economic Decision Models as Simple as Possible, But Not Simpler? Introducing SMART tool
Can We Make Health Economic Decision Models as Simple as Possible, But Not Simpler? Introducing SMART tool
Developing health economic decision-analytic models requires making modelling choices to simplify reality while addressing...
Microsimulation Modeling for Health Decision Sciences Using C++: A Tutorial
Microsimulation Modeling for Health Decision Sciences Using C++: A Tutorial
Microsimulation models have become increasingly common in the field of decision modeling for health. Because microsimulati...
The Cost-Effective Price of Lecanemab for Patients with Early Alzheimer’s Disease in Sweden
The Cost-Effective Price of Lecanemab for Patients with Early Alzheimer’s Disease in Sweden
We sought to estimate the cost-effective price for lecanemab for treating early Alzheimer’s disease in Sweden from t...
Evaluating the Role and Policy Implications of Using External Evidence in Survival Extrapolations: A Case Study of Axicabtagene Ciloleucel Therapy for Second-Line DLBCL
Evaluating the Role and Policy Implications of Using External Evidence in Survival Extrapolations: A Case Study of Axicabtagene Ciloleucel Therapy for Second-Line DLBCL
Health technology assessment (HTA) of haemato-oncology therapies typically requires extrapolation of long-term survival be...
Bayesian Cost-Effectiveness Analysis Using Individual-Level Data is Sensitive to the Choice of Uniform Priors on the Standard Deviations for Costs in Log-Normal Models
Bayesian Cost-Effectiveness Analysis Using Individual-Level Data is Sensitive to the Choice of Uniform Priors on the Standard Deviations for Costs in Log-Normal Models
Bayesian cost-effectiveness analysis (CEA) requires the specification of prior distributions for all parameters to be empi...
Lifetime Healthcare and Long-Term Care Costs of Heart Failure: Estimates Using Administrative Data from Hospitalized Patients in the Netherlands
Lifetime Healthcare and Long-Term Care Costs of Heart Failure: Estimates Using Administrative Data from Hospitalized Patients in the Netherlands
Heart failure (HF) is a complex clinical syndrome associated with high mortality and extensive healthcare use. Using longi...
Developing a Comprehensive Framework for Cost-Effectiveness Evaluation in Metastatic Castration-Sensitive Prostate Cancer: Insights from a Systematic Review
Developing a Comprehensive Framework for Cost-Effectiveness Evaluation in Metastatic Castration-Sensitive Prostate Cancer: Insights from a Systematic Review
Metastatic castration-sensitive prostate cancer (mCSPC) imposes a significant economic burden and necessitates more cost-e...
Eliciting and Anchoring Health State Preferences Using Discrete Choice Experiments Among Adults, Adolescents, and Children
Eliciting and Anchoring Health State Preferences Using Discrete Choice Experiments Among Adults, Adolescents, and Children
We aimed to compare EQ-5D-Y-5L health state preferences among children, adolescents, and adults in Canada using a discrete...
Cost–Utility Analysis of Treatment Sequences for Moderate-to-Severe Crohn’s Disease
Cost–Utility Analysis of Treatment Sequences for Moderate-to-Severe Crohn’s Disease
The clinical pathway for patients with moderate-to-severe Crohn’s disease (CD) typically includes sequential pharmac...
How Does Bereavement Affect the Health-Related Quality of Life of Household Members Who Do and Do Not Provide Unpaid Care? Difference-in-Differences Analyses Using the UK Household Longitudinal Survey
How Does Bereavement Affect the Health-Related Quality of Life of Household Members Who Do and Do Not Provide Unpaid Care? Difference-in-Differences Analyses Using the UK Household Longitudinal Survey
Guidelines for modelling in economic evaluation recommend that it may be necessary to consider costs and outcomes until al...
Value of Innovative Multiple Myeloma Treatments from Patient and Healthcare Provider Perspectives: Evidence from a Discrete Choice Experiment
Value of Innovative Multiple Myeloma Treatments from Patient and Healthcare Provider Perspectives: Evidence from a Discrete Choice Experiment
Although innovation generally provides measurable improvements in disease characteristics and patient survival, some benef...
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